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中国红客联盟_百度百科

联盟_百度百科网页新闻贴吧知道网盘图片视频地图文库资讯采购百科百度首页登录注册进入词条全站搜索帮助首页秒懂百科特色百科知识专题加入百科百科团队权威合作下载百科APP个人中心收藏查看我的收藏0有用+10中国红客联盟播报讨论上传视频中国境内的民间黑客组织中国红客联盟，又叫H.U.C。成立于2000年底，是由黑客界LION牵头组建的，吸纳了全国众多黑客高手，该组织主要反击国外一些黑客的攻击。红客联盟于2004年12月31日成立四周年之际，在其网站上发表公开信，宣布解散，同时关闭网站。2011年9月22日宣布重新组建，新网站于2011年11月1日开放。2015年11月17日18时左右，对于网络流传的“中国红客联盟宣战 ISIS”一事，微博认证信息为“深圳红客联盟科技有限公司”的@中国红客联盟官方微博发布消息，否认向 ISIS 发起攻击。 [1]2016年12月13日，新京报记者采访了中国红客联盟负责人邵彤先生，并为记者解答了“黑色产业链”相关问题。 [2]2022年7月6日，中国红客联盟突然宣布，即日起宣传解散，并更名为弘客联盟。 [7]公司名称中国红客联盟外文名H.U.C成立时间2000年12月31日员工数80000 人牵头组建黑客界LION重新组建2011年9月22日目录1历史沿革▪红客发展▪反击事件2联盟成员3联盟性质4联盟文化▪宗旨▪目标5联盟纪律6社会评价历史沿革播报编辑红客发展中国红客联盟纪念页 [3]红客起源于1999年的五八事件，在美国炸中国驻南联盟大使馆后，一些中国黑客建立了一个联盟名为中国红客联盟(HUC)。组织成员利用联合的黑客技能，为表达爱国主义和民族主义，向一些美国网站，特别是政府网站，发出攻击。“中国红客联盟”成立于2000年12月31日，由lion所建立。2004年12月31日，创始人LION突然发布了一封公开信，称“中国红客联盟”已经名存实亡，没有存在的必要。随后，中国红客网站关闭，7名核心成员在网络世界更如人间蒸发。 [4]2005年，中国红客联盟重新组建，时隔一月，随之解散。2008年8月25日，红盟重组，默默支持奥运会的正常举行，在2009年，中国红客联盟重新开站。2011年9月22日，宣布重新组建，新网站于2011年11月1日开放。反击事件2001年攻击美国海军资源网站的截屏图1998年5月，因印度尼西亚发生动乱，在此期间，大批华人受到迫害，华人妇女遭到令人发指的强暴，中国红客联盟反击印尼网络。1999年5月，因在1999年科索沃战争初期，中国黑客并没有对美国及北约国家网站采取太多的过激行为。中国红客联盟反击美国网络。1999年8月反击台湾网络，因1999年7月9日，李登辉在接受“德国之声”专访时，所提出了所谓“两国论”。2000年1~2月反击日本网络，因2000年1月21日，日本最高法院无视历史事实，悍然判决参加过当年南京大屠杀的老兵东史郎见证大屠杀的诉讼败诉。中国红客联盟纪念页 [3]2001年反击日本网络，因跨入新的世纪后之后，三菱车事件、日航事件、教科书事件、《台湾论》事件。2001年4月~5月，因2001年4月1日，美国军用侦察机将中国战机撞毁，导致飞行员王伟坠海死亡。反击美国网络，lion组织中国红客联盟8万会员应对美国及其黑客组织的攻击，并成功反击将白宫网站攻陷！2004年12月31日，LION在网站上宣布红盟解散，从此网上突然多出了众多中国红客联盟网站。2015年11月17日18时左右，对于网络流传的“中国红客联盟宣战 ISIS”一事，微博认证信息为“深圳红客联盟科技有限公司”的@中国红客联盟官方微博发布消息，否认向 ISIS 发起攻击。 [1]2016年12月13日，新京报记者采访了中国红客联盟负责人邵彤先生，并为记者解答了“黑色产业链”相关问题。 [2]联盟成员播报编辑以下名单截至2011年lionbkbllyayanikinanarefdomformatuhhuhy蝶起甜心墨斗鱼Nan男神联盟性质播报编辑本安全团体全称为中国红客网络技术联盟，对应的英文名字是Honker Union of China.（缩写 HUC），简称红客联盟（红盟）。红客联盟（红盟）是一个非商业性的民间技术机构。主要由爱好计算机爱好者组成。进行有计划有组织的计算机技术方面的研究、交流、整理、和推广工作。同时，红客联盟（红盟）是一个民间的爱国团体，我们不参与政治，我们的一切言论和行动都建立在爱国和维护中国尊严的基础上，我们的声音和行动是中华民族气节的体现。联盟文化播报编辑宗旨红客联盟（红盟）的宗旨是：团结协作、务实创新。目标1.红客联盟（红盟）的近期目标是：提高成员的计算机水平，提高国内的网络安全意识，发布有关于网络安全知识的相关文档，公布最新的系统漏洞以及发布补丁等。2.红客联盟（红盟）的长期目标是：希望能推动计算机技术的发展，探索和涉足计算机技术的未来。联盟纪律播报编辑1.任何红客联盟成员或其他个人不得以红客联盟组织名义或者以红客联盟成名义发布公告、政治性言论、反动言论等；红客联盟承诺不会对国内站点实施攻击，任何红客联盟成员或其他个人不得以红客联盟组织名义或者以红客联盟成员名义对国内站点和网络实施攻击；任何使用有关红客联盟组织名义或者红客联盟成员名义实施破坏、假冒、反动等损害红客联盟组织形象的行为，红客联盟将予以追查，并保留法律追诉权利。2.成员不得以组织的名义从事违法、有损公共道德或以满足个人利益为目的活动。如有违反，后果一切自负，红客联盟保留法律追诉权利。3.成员不得利用自身的技术进行危害网络安全的行为，不得违反国家关于网络安全方面的法律法规。任何人不得以任何名义对任何国内合法站点进行任何形式的攻击。如有违反，取消其成员资格，后果一切自负，红客联盟保留法律追诉权利。4.成员不得以联盟的名义或利用联盟的web、maillist、新闻组、论坛、聊天室、服务器以及一切联盟提供的交流场所和手段，发表政治性言论、对他人进行攻击、进行有悖伦理道德的活动或用作商业用途，红客联盟保留法律追诉权利。5.成员应当本着团结协作的宗旨，相互帮助，对于成员提出的技术问题，了解情况的应当积极的给予答复。6.成员不得参与其他的同类的组织和团体，但允许进行互相的技术交流。社会评价播报编辑红客官网：红客就是从事网络安全行业的爱国黑客。红客是爱憎分明、疾恶如仇的。红客的原则是，遇事而出，凡是与中国过不去的，中国红客联盟就下山；凡是要损害中华民族利益的，中国红客联盟将出动…… [5]中国社会科学院新闻与传播研究所网络与数字传媒研究室主任闵大洪：客观地说，黑客行动肯定是各国法律不允许的行为，因为它打乱了正常的网络秩序。但是黑客现象的一个客观作用就是提醒人们注意网络安全的问题，及时发现技术漏洞，开发网络安全软件。 [5]红客联盟创始人Lion：首先，黑客的定义很多，我眼中的黑客是热爱网络技术的人。黑客，只有很高的网络技术、编程技巧和遵守黑客原则的才配称为黑客。红客，红客不完全等同于黑客，红客精神里更多的是爱国热情：红客和当前政治状态有关；红客不等于黑客。解析中国黑客X档案：中国红客联盟在中美黑客大战中的杰出表现将永远写进中国的史册。 [6]新手上路成长任务编辑入门编辑规则本人编辑我有疑问内容质疑在线客服官方贴吧意见反馈投诉建议举报不良信息未通过词条申诉投诉侵权信息封禁查询与解封©2024 Baidu 使用百度前必读 | 百科协议 | 隐私政策 | 百度百科合作平台 | 京ICP证030173号京公网安备110000020000

在哈尔滨商业大学（HUC）就读是怎样的一番体验？ - 知乎

在哈尔滨商业大学（HUC）就读是怎样的一番体验？ - 知乎首页知乎知学堂发现等你来答切换模式登录/注册哈尔滨黑龙江省财经类大学哈尔滨商业大学(HUC)双非高校在哈尔滨商业大学（HUC）就读是怎样的一番体验？关注者229被浏览553,464关注问题写回答邀请回答好问题 31添加评论分享89 个回答默认排序匿名用户2018.1.16更新补充: 算了一下在商大截至目前获得的奖学金，国奖+国家励志+校奖+单项总共捞金17300，嘻嘻。------------------首答分割线---------------14级商大在读，忍不住回答这个问题。一、商大带给我的1.国奖；2.自由: 大二很随意地换了专业，之后选课全凭自己喜好在很多班级之间随便挑，算是轻微地摆脱制度的控制，专业老师比较重视考试成绩，自己考试成绩平均分均90+，也因此可以少一些无奈的妥协。3.多项国家级、省级竞赛获奖（嗯。。有一些是比较水，都是和自己的学科有关，促进了后面的保研）。4.保研：上海某211（保研专业全国排名top3，拒绝了某垫底985的offer）。二、商大教会我的1.学会拒绝。大一下因为成绩好（基本是每个专业第一第二？）收到英才学院的电话邀请，问我是否愿意插班转入英才，当时感觉自己DIAO炸天，英才很low，拒绝（嗯。。只是自己的主观印象，英才收进来的分很高，但听说大一强制自习时大部分人都在比着玩手机，有一次全校大会英才全穿着校服样服装，感觉可怕，像高中生）；大二转走，成绩平均分95+，目测是全院所有专业最高，很多人劝+质疑，挽留均拒绝。2. 人际关系。不可否认辅导员在评一些校级荣誉、国奖、甚至保研过程中起的作用大，具体体现在：某保研学姐拿不到优秀毕业生（笑死人）、大一平均分最高却拿不到国奖还败给某学生干部（关系使然，某辅导员电话里亲口说的）、某交际花成绩一般却成功保研（保研文件都不齐全都保研了），尤其谜一般的综测分设置，有些人读完了都不知道综测到底哪些可以加分，相关文件从来都是学委秘密保管，学院还可以年年随意更改文件（呵呵呵）。而我能做的只是每学期成绩第一+综测第一+加一个自己喜欢的部当部长为学院work work work，以驱散一些质疑是靠吃综测和关系吃起来的质疑（有质疑就直接回：因为我成绩比你好+综测比你高+还额外为学院work？）。还有辛大大真的很好，帮了我很多（可能也是因为我成绩在全校排得上名次。。。）。3.自作自受。一些学弟妹来了商大就开始抱怨寝室环境、教学云云，然后自己又逃课挂科（直白说这不是很配？？），特别一些人大学四年打游戏度日，回头又抱怨商大没教好自己（我大HUC什么时候教过你让你打游戏的？？）的，什么心理？送你四个字：自作自受？证明自己被埋没的可行方法难道不是做出让人发出“啊，这么厉害的人竟然在这个学校里出现！”之感叹的事？？总之吧，HUC只是一个学校，一个平台，可能不会给你加多少分，但平台在那儿，会发光的人自然会发光，暗淡的人也不会因为平台的存在而更暗淡。少做梦，多做事。知乎首答，以上。编辑于 2018-01-16 21:04赞同 16767 条评论分享收藏喜欢收起青青做个平凡的人关注1，校园环境很好，有镜湖、喷泉，还有一个能承办很多赛事的超大体育场。2，住宿条件，额，我住的就是最糟糕的六人间了。只能说，真的很糟糕，但是，你可以自己好好收拾一下。这是我的床，我自己布置了一下。3，地处哈尔滨，经济不太发达，信息闭塞。东北经济实力真的一般，我来自南方，感觉更是强烈。所以在哈尔滨，在商大学习的话，一定要学会自己主动的去学习，利用互联网去增长见识，有空多出去走走，如果你不考研，建议多做点对就业有用的事情。4，学校再怎么样，都比不上自己四年里面的努力，认清目标，建立正确三观来的重要。5，对了，有空一定要去听听，周游，郝大江，隋如彬，张型双的课。^_^6，还有一定要关注微信号，商大百科哦编辑于 2016-07-23 12:29赞同 4830 条评论分享收藏喜欢

夯实水泥土桩处理软基施工工法_百度百科

土桩处理软基施工工法_百度百科网页新闻贴吧知道网盘图片视频地图文库资讯采购百科百度首页登录注册进入词条全站搜索帮助首页秒懂百科特色百科知识专题加入百科百科团队权威合作下载百科APP个人中心收藏查看我的收藏0有用+10夯实水泥土桩处理软基施工工法播报讨论上传视频由河北路桥集团有限公司、科达集团股份有限公司完成的工法《夯实水泥土桩处理软基施工工法》是河北路桥集团有限公司、科达集团股份有限公司完成的建筑类施工工法，完成人是胡月、聂增芳、李超、吴志国、赵月平。该工法适用于粉土、黏土、素填土、杂填土、淤泥质土等地基。 [1]《夯实水泥土桩处理软基施工工法》主要的工法特点是：施工质量容易控制、周期短、造价低、施工文明等。 [1]2011年9月30日，《夯实水泥土桩处理软基施工工法》被中华人民共和国住房和城乡建设部评定为2009~2010年度国家二级工法。 [2]中文名夯实水泥土桩处理软基施工工法工法编号GJEJGF179-2010完成单位河北路桥集团有限公司、科达集团股份有限公司主要完成人胡月、聂增芳、李超、吴志国、赵月平审批单位中华人民共和国住房和城乡建设部主要荣誉国家二级工法（2009-2010年度）目录1形成原因2工法特点3操作原理▪适用范围▪工艺原理▪施工工艺4材料设备5质量控制6安全措施7环保措施8效益分析9应用实例10荣誉表彰形成原因播报编辑随着经济建设的快速发展，各种高、新建筑工程和大规模道路工程日益增多，这对地基承载力和沉降控制提出了更高的要求。实际工程中往往遇到很多天然地基不能满足工程需要的情况，必须进行处理。而在众多地基处理技术中，复合地基处理技术的应用十分广泛。复合地基是由两种模量不同的材料（桩间土和桩体）复合而成且两者在共同承担由相对刚性基础所传递的上部荷载时能产生协调变形的人工地基。夯实水泥土桩是21世纪发展起来的首先应用于房建工程地基处理的一种方法，它主要用于地下水位比较低的地区，在中国北方地区尤其是北京、河北等地广泛应用。随着工程建设的飞速发展，地基处理手段也日趋多样化，复合地基由于充分利用桩间土和桩共同作用的特有优势和相对低廉的工程造价得到了越来越广泛的应用。大广高速公路京衡段应用《夯实水泥土桩处理软基施工工法》，利用工程用土料和水泥拌合形成混合料，通过各种机械成孔方法在土中成孔并填入混合料夯实，形成桩体，从而形成复合地基，充分发挥了水泥土桩的抗变形性能，提高地基承载力、减小地基变形的地基处理方法。 [1]工法特点播报编辑《夯实水泥土桩处理软基施工工法》的工法特点是：一、夯实水泥土桩与搅拌水泥土桩（浆喷、粉喷桩）的主要区别在于：搅拌水泥土桩桩体强度与现场土的含水量、土的类型密切相关搅拌后桩体密度增加很少，桩体强度主要取决于水泥的胶结作用，由于地层的不均性，桩体强度也存在不均匀性。夯实水泥土桩水泥和土在孔外拌合，均匀性好，桩体强度水泥的胶结作用为主，桩体密度增加也是构成桩体强度的重要分量，桩体强度均匀。另外，由于夯实水泥土桩是将孔外拌合均匀的水泥土混合料回填孔内并强力夯实，相同水泥掺量下夯实水泥土桩的桩体强度为搅拌水泥土桩的2~10倍。二、夯实水泥土桩一般使用于地下水埋藏较深，或有地下水但土的渗透系数小于5~10厘米/秒的黏性土，孔深一般为6~10米。当土的承载力标准值f>60千帕时，可采用长螺旋钻机和人工洛阳铲排土成孔。当土的承载力标准值f<60千帕的松散填土或塑性指数较小的土时，除考虑桩的置换作用外，宜应考虑采用挤密成孔工具，通过挤土成孔，可使桩间土承载力得到较大提高。夯实水泥土桩从21世纪的施工经验上来看，处理并解决300千帕承载力的地基已比较成熟。三、夯实水泥土桩具有施工质量容易控制、周期短、造价低、施工文明等一系列特点。通常拟建场地的勘察，孔位布置按勘察规范孔距不可能布得很小。对有的岩性变化大的场地，不可能反映得很全面。夯实水泥土桩复合地基桩距一般在l米左右，成孔时每个孔都可视为一个探坑，对土层变化一目了然，弥补了勘察阶段的不足，对及时发现土层的异常变化是很有利的。由于成孔时又是对土层变化的又一次探查，可保证施工时将桩端落在好的土层上。四、施工速度快、工期短也是夯实水泥土桩复合地基的优点。一般情况下，四单元六层住宅楼条形基础地基处理，采用夯实水泥土桩只需7~10天即可完工。施工过程中，水、电供应往往是制约施工进度的一个重要影响因素。由于夯实水泥土桩是有人工和机械施工两套工艺，当停电时，可改用人工洛阳铲成孔代替机械成孔，用人工夯实代替机械夯实。五、水泥土强度随龄期增长而提高，桩体三轴应力-应变关系与围压关系不大；桩体具有较好传递垂直荷载能力。六、通常天然地基土含水量适宜，配制水泥土时无需增加更多的水分。所以停水停电对夯实水泥土桩施工影响不大。七、施工现场无泥浆污染和噪声污染，场地狭窄，大型机械无法进场时，采用夯实水泥土桩则有很强的适应性。八、由于夯实水泥土桩，除水泥外，制桩的建筑材料就是土，可以就地取材，即可利用成孔或开挖时的弃土，成本低、造价低廉。九、夯实水泥土桩具有较好抗冻性，成桩后冻结对桩体不产生较大的强度降低。 [1]操作原理播报编辑适用范围《夯实水泥土桩处理软基施工工法》适用于粉土、黏土、素填土、杂填土、淤泥质土等地基，施工机具简单，施工质量容易控制，施工速度快，工期短，不受停水、停电影响，造价低廉，且施工文明，无泥浆无噪声。通常复合地基承载力可达180~300千帕。根据施工机具水平，多用于地下水位埋藏较深的地基土，当有地下水时，适于渗透系数小于10~5厘米/秒的黏性土及桩端以上50~100厘米有水的地质条件。 [1]工艺原理《夯实水泥土桩处理软基施工工法》的工艺原理叙述如下：夯实水泥土桩是将水泥和土料在孔外充分拌匀然后回填孔内并强力夯实形成具有一定强度的水泥土加固体，复合地基由两种模量不同的材料（桩间土和桩体）组成的，在相对刚性基础下两者共同分担上部荷载并协调变形的人工地基。复合地基犹如钢筋混凝土，其中地基中的桩体犹如混凝土中的钢筋，它的实质就是考虑桩土共同作用。夯实水泥土桩作为中等粘结强度桩，在施工过程中，水泥和土体发生了复杂的物理化学反应和夯实挤密作用。一、胶结作用：水泥与土体搅拌时，水泥颗粒表面的矿物很快与土体中的水发生水解和水化反应，生成氢氧化铁、含水硅酸钙、含水铝酸钙等各种水化物，这些水化物有的自身继续硬化，形成水泥石骨架；有的则与周围具有一定活性的黏土颗粒反应，通过Na+、K+、小时2+之间的交换，使较小的、离散的黏土颗粒互相靠拢胶结，形成较大的土的团粒，另一方面，水泥水化反应生成的凝胶粒子比表面较原来的水泥颗粒大1000多倍，因而产生很大的表面能，使之具有强烈的吸附活性，能把较大的土的团粒进一步胶结，形成水泥土的团粒结构，使水泥土的强度提高，即水泥土的胶结强度。二、夯实挤密作用：水泥和土体在孔外拌合均匀形成的水泥土拌合料较为松散，土团之间孔隙较大，连接力微弱，随着夯实次数即夯击能的增加，混合料土团会重新进行排列，体积压缩，密度增大，强度明显提高。在一定夯实能的情况下，对应最佳含水量的干密度为最大千密度，亦即在夯击能确定后，只要施工时能将桩体混合料的含水量控制到最佳含水量，就可获得施工桩体的最大干密度和桩体的最大夯实强度。桩体的密实和均匀，是由夯实水泥土桩夯实机的夯锤质量及起落高度来决定的，当夯锤质量和起落高度一定，夯击能为常数，桩体密实均匀，强度则会提高，质量可得到有效保证。 [1]施工工艺工艺流程《夯实水泥土桩处理软基施工工法》的施工工艺流程见下图。 [1]施工工艺流程操作要点《夯实水泥土桩处理软基施工工法》的操作要点如下：一、试桩在夯实水泥土开工前，应根据地质情况选取代表性工点，做不少于5根工艺试桩，以便取得符合设计要求的工艺控制数据，其中包括成孔速度、孔底夯实击数、水泥土含水量控制、夯锤高度、分层厚度、夯实次数、压实系数、触探击数等数据，并经质量检验合格，写出试桩总结报告，经监理工程师批准后方可正式开工。试桩取得的各项数据作为施工控制的依据，在施工中严格遵守认真执行。二、配合比设计水泥：石家庄鹿泉市曲寨牌P.S.A32.5级矿渣硅酸盐水泥。抗折强度3天：3.7兆帕，28天：7.8兆帕抗压强度3天：17.4兆帕，28天：40.6兆帕。土：标段沿线原地表3米以内的土。液限28.1%，塑限16.6%，塑性指数11.5%属低液限黏土。配比试验步骤：1.根据试验测得水泥比重为3000千克/立方米，土的比重为2650千克/立方米，根据设计要求水泥与土的实方比为1:6即水泥与土的质量比为1×3000:6×2650=1:5.3，按照配合比设计原则，应配制不同的实方比，则水泥与土的实方比为1:7时同理得出质量比为1:6.18，水泥与土的实方比为1:5时得出质量比为1:4.42。2.根据水泥与土的质量不同比例测出水泥与土混合以后的最大干密度和最佳含水率。击实方法采用《水泥土桩复合地基承载技术规范》DB 13（J）39-2003，采用轻型击实仪，将混合料分5层次倒入击实筒中，每层击实25击。试验测得最大干密度和最佳含水率见下表。最大干密度和最佳含水率（实方比）水泥:土最大干密度（克/立方厘米）最佳含水率（%）1:51.8017.01:61.7815.31:71.7513.83.根据水泥和土不同的质量比得出最大干密度和最佳含水率分别计算、配制、成型试件，测密度和质量后，先自然养护6小时然后将试样置入混凝土标养室，覆盖一层塑料薄膜养护28天，为了更好的掌握试件的强度另外成型一组测试7天强度的试件。结果见下表。7天强度试件（实方比）水泥:土7天强度28天强度1:53.25.01:63.13.81:72.53.64.由上述试验结果得出水泥与土的体积比为1:6时，28天强度满足设计要求，确定为试验室夯实水泥土桩的配合比各项控制标准：（1）最大密度：1.78（克/立方厘米）。（2）最佳含水率：15.3%。（3）水泥与土质量比：1:5.3。（4）每方水泥用量为279千克，土的用量为1481千克。三、螺旋钻机就位根据定位控制点、轴线及桩位布置图用钢尺量距定出桩位，并用直径16的钢钎打20厘米深度的孔灌白灰进行标记。钻孔机就位时，必须保持平稳，不发生倾斜、移位。现场控制采用在钻架上挂锤球的方法测量成孔的垂直度，也可采用钻机自带垂直度调整器控制钻杆垂直度。每根桩施工前现场工程技术人员进行桩位对中及垂直度检查。满足要求后，方可开钻。为准确控制钻孔深度，应在桩架上或桩管上作出控制的标尺，以便在施工中进行观测、记录；为保证不发生偏位。钻机就位后，应使钻杆垂直对准桩位中心，确保垂直度容许偏差不大于1%。四、成孔及检查成孔质量1.成孔：调直机架挺杆，对好桩位（用对位圈），钻孔开始时，关闭钻头阀门，向下移动钻杆至钻头触地时，启动电机钻进，先慢后快，同时检查钻孔的偏差并及时纠正，钻进速度应根据电流值的变化及时调整。在成孔过程中发现钻杆摇晃或难钻时，应放慢进尺，防止桩孔偏斜、位移和钻具损坏。有效的施工控制方法是：在每一垂直、平行路基方向的最端头的两颗桩轴线上，往外引申3~5米设置0.8米高，底面长度为0.6厘米长，斜长为1米的三角架作为校核施工时的偏位和垂直度偏差；在平行路基主线方向桩位。以3点直线原理控制偏位，简单易行，效果好。根据钻机塔身上的进尺标记，成孔到达设计标高时，停止钻进并进行提钻。（1）钻机就位后必须保持平稳，钻尖对准桩位误差小于等于50毫米，然后调直桅杆并用双向垂直吊针调整。待塔架铅垂并经项目经理认可后开始钻进成孔，下图1~下图5。图1 螺旋钻机钻孔就位图2 夯实桩布桩螺旋钻机钻孔1图3 夯实桩布桩螺旋钻机钻孔2图4 夯实水泥土桩成孔1图5 夯实水泥土桩成孔2（2）孔底清理，钻进达到设计深度后停钻，空钻排土1分钟后提钻。虚土厚度不得超过50毫米，否则需再次下钻清底。钻进过程中散落在地表的弃土必须随时清理外运。（3）孔口防护，钻机移位后用两块300毫米×900毫米钢板并排将孔口封盖，以防车辆碾压及地表杂物掉入孔内。（4）钻机向后行驶顺序施工，防止因前行造成钻机底盘滑道碾压孔口。2.检查成孔质量：（1）钻深测定：用测深绳（锤）测量孔深及虚土厚度。虚土厚度等于测量深度与钻孔深的差值。虚土厚度一般不应超过10厘米。（2）孔径控制：钻进遇有含石块较多的土层，或含水量较大的软塑黏土层时，必须防止钻杆晃动引起孔径扩大，致使孔壁附着扰动土和孔底增加回落土。经常核对地质情况，遇到软塑土层时减慢钻进速度。（3）孔底土清理：钻到预定钻深后，必须在深处进行空转清土，然后停止转动；提钻杆，不得回转钻杆。孔底的虚土厚度超过质量标准时，要分析原因，采取处理措施。进钻过程中散落在地面上的土，必须随时清除运走。（4）移动钻机到下一位：经过成孔质量检查后，应按表逐项填好桩孔施工记录。然后盖好孔口盖板，并力求防止在盖板上行车走人，最后再移走钻孔机到下一桩位。五、混合料拌合1、选择土料：土料宜选用基坑开挖中的粉土，且要注意有机质含量小于5%。2、粉制过筛：自制粉土机粉碎后过20毫米×20毫米筛子，筛好的土料在土堆的坡脚处应清除土颗粒，同时用铁锹翻拌。在土料含水率偏低的情况下，让经验丰富人员使用压力喷嘴以雾状喷洒，水压一定要足，以保证成雾效果。3、调制土料：为保证成桩效果，要提前做试验确定素土的含水率的最佳范围，以保证混合料的含水率控制在最优含水率士1.5%之内。该项工作应由技术人员把关，每班每堆土要检测2次，合格后方可运输，喷水后的土料用塑料薄膜覆盖24小时，以保证闷制后土料充分吸水，达到上下含水量均匀运到现场后仍需用塑料薄膜覆盖，随用随取，防止水分散失。4、螺旋钻机钻出的土检验合格后方可使用，采用人工码条，先用拌合机拌合1遍，土最大颗粒不大于5毫米，基本上不用过10~20毫米筛，测定土的含水量控制在17%左右。按照试验配合比即1:6配制混合料并充分搅拌（搅拌时间以60秒左右为宜，时间过短搅拌不充分，时间过长易搅拌成球）后即可出料。搅拌后混合料除按规定送实验室即时检验外，还应通过现场试验及经验测定（手握成团，落地即散），搅拌好的混合料应在2小时内成桩，超时即为作废。配制好的水泥土达到色调一致。如下图1、下图2。图1 混合料拌合图2 灰剂量检测六、含水量的控制桩体由水泥土混合料夯填而成，试验证实：在相同水泥掺量条件下，桩体密实度是决定桩体强度的主要因素，而混合料含水量则是决定桩体夯实密度的重要因素之一，含水量过高和过低都会影响夯实效果。工地实际的试验证明：夯实水泥土的最大干密度接近于土料的最大密度，夯实最佳含水量为土料最佳含水量Wop±1~2%，该时，夯实水泥土有最大强度。现场施工时，压实系数应大于0.93。无论是机械夯实，还是人工夯实，均应由现场试验来确定混合料含水量，现场也可以采用一种简易的判别方法：混合料“手握成团，掉地即散”为标准。混合料必须随拌随用，拌合好的混合料必须在2个小时以内成桩，超时即为废料，不得用于成桩。七、成桩施工及褥垫层施工（下图1~下图4）图1 回填夯实1图2 回填夯实2图3 成桩图4 褥垫层1.夯实水泥土桩桩径一般为350毫米或400米，夯锤可采用梨形锤或锥形锤，锤径330毫米，锤重不小于150千克，落距90~100厘米。2.夯实机械采用夹板自落式夯实机。夯机就位要固定好保持机身平稳，两侧轮胎离地通过前后4个支撑来稳定夯实机。夯锤中心要对正孔中心，以防夯锤擦壁损耗夯击能，然后核查孔深及孔内有无杂物。夯机底下加工轨道，便于夯机能横向、竖向行走和定位。夯锤呈纺锤型，夯锤直径为设计桩径的80%。夯锤质量大于120千克，垂直落距≥0.8米。3.夯机就位后在四角进行直径20毫米的钢钎打进地面一下1米左右进行固定并保持机身稳定，然后在次确认孔深及孔内有无杂物，如孔深不符或有杂物及遇到缩颈、塌孔等问题必须先进行处理，符合施工要求后再使夯锤中心对准孔中心。4.在桩身较短时，端承载力占有一定比例，因此孔底必须夯实，成桩前孔底空夯次数宜进行试验，直至出现清脆响后方可填料。如孔底局部渗水或含水量过高，可在落锤前进行填入20厘米厚的碎石或干拌混凝土，同时提高空夯次数以保证桩底坚实。5.每班均要测量夯锤落距，保证设计夯击能。如果基底地质情况较好，先夯击5次，夯锤提升高度1米（比设计提高20厘米）。6.夯实机前1米外放置两块1米×2米铁块，用于堆放混合料，确保混合料不与地表土混杂。7.夯实方法为一投（料）三夯（击），连续作业直至成桩，每次填料量厚度不大于50毫米。通过上述措施，有效防止了人为的突击填料现象。实践证明，第三夯对成桩质量作用显著，三夯时，夯击有清脆声响。桩体的压实系数不小于0.93，桩顶以下1.0米时增加一击即一填3击。当桩顶夯至距地表以下0.5米时再连续夯5击。夹板自落式夯实机进行桩上部夯实时，夯锤晃动较大，易使上部土渣进入孔内，影响成桩质量，加入夯锤导正装置，可避免这一问题。桩体采用N10检测时在桩头以下1.5米范围内进行，每30厘米为一段，单桩各段平均击数大于等于80击，每段最少击数大于等于60击，抽检比例为总桩数的15%。8.桩间土开挖分两步进行，第一步开挖至设计标高上10厘米，待剃凿上部桩头后，再次开挖到位。9.桩头剃凿分两步进行，第一步剃凿至设计标高上10厘米，待二次开挖桩间土后，剃凿到位并整平桩头。10.剃凿桩头要沿着4个方向均匀剃凿，待各方向均凿进后，再一次将整个桩头剃下，防止一次性剃凿或沿一个方向剃凿造成桩头劈裂。11.为保证桩体上下均匀，保护桩头确定以500毫米为宜。12.褥垫层采用0.5~2厘米级配碎石，铺平后用机械碾压或震密。八、封顶夯实后桩顶应高出标高200毫米，在进行上层施工时，将设计桩顶标高以上的桩段用人工挖除，桩顶面应水平、完整。九、现场试验成桩过程中，抽样做混合料试块，每台机械每台班应做一组（3块），试件直径高=100×100毫米的圆柱体，标准养护，28天后进行抗压试验，试件极限抗压强度应大于或等于桩体设计强度的2~3倍。 [1]材料设备播报编辑《夯实水泥土桩处理软基施工工法》所用的材料及设备明细如下：一、材料夯实水泥土桩桩体材料主要由水泥和土的混合料组成。1、夯实水泥土桩所用水泥应符合设计要求的种类及规格，宜采用32.5级或42.5级矿渣水泥或普通硅酸盐水泥，进场水泥应进行强度和安定性检验，并具有质量合格证。2、夯实水泥土桩的土料宜采用黏性土、粉土、粉细砂或渣土，土料中有机物质含量不得超过5%，不得含有冻土或膨胀土，使用时应过10~20毫米筛。3、夯实水泥土桩的混合料要按设计配合比配制，并搅拌均匀，含水量与最优含水量允许偏差为±2%。当用机械搅拌时，搅拌时间不应少于1分钟。当用人工搅拌时，拌合次数不应少于3遍。混合料拌合后应在2小时内用于成桩。4、使用普通生活饮用水。二、施工设备长螺旋钻机、粉土机、拌合机、夯实机等。 [1]质量控制播报编辑《夯实水泥土桩处理软基施工工法》的质量控制要求如下：一、成孔质量控制1、桩孔中心偏差不应超过桩径设计值的1/4，对条形基础不应超过桩径设计值的1/6。2、桩孔垂直度偏差不应大于1.5%。3、桩孔直径不得小于设计桩位。4、桩孔深度不应小于设计深度。5、桩孔内填料前孔底必须夯实（一般不得少于8~10次），夯实锤底回弹时止。6、做好成孔记录，应把成孔过程当作地质再勘察过程，如发现地基土质与勘察资料不符时，应查明情况，并采取有效处理措施。二、水泥土拌合料质量控制1、水泥按设计强度等级和品种使用，水泥掺合比按设计要求进行施工前试。2、土料尽量选用较纯的粉细砂、粉土黏土或素填土，严禁使用耕土、淤泥土、冻土、膨胀土或有机含量>3%的土。3、水泥土拌合料含水量控制在最优含水量的3%范围内。4、水泥土拌合料要拌合均匀，人工拌合不少于3遍，机械拌合不少于3分钟。5、水泥土拌合料以最大干密度为控制指标，使最大千密度接近土料的最大千密度为佳。三、夯填成桩质量控制1、分层回填水泥土拌合料并夯实，分层厚度及夯击次数由试验确定。2、水泥土拌合料压实系数≥0.93。3、桩顶夯填高度应大于设计桩顶标高00~500毫米以上，垫层施工时应将多余桩体凿除，桩顶应水平。4、桩顶褥垫层按设计厚度和材料铺筑，严禁使基底土层扰动。褥垫层夯填度不得大于0.9。5、轻型圆锥动力触探试验：该法检测桩体夯实质量，在现场成桩2小时内锤击（N10），连续贯入6步，每步30厘米，一般每30厘米击实不小于40击，则成桩合格。抽检数量不应少于总桩数的2%。6、用现场载荷试验方法进行单桩复合地基承载力检测，特征值不应小于160千帕。检验数量为总桩数的0.5%~1.0%，并不得少于3处。水泥土桩单桩复合地基载荷试验：由有测试资质的单位用该法检测夯实水泥土桩复合地基承载力是否满足实际要求。一般采用单桩复合地基载荷试验。载荷板面积应按单桩所承担的处理面积确定。7、从成桩结束到开始检测的间歇时间不应小于15天。8、关于桩的室内试验、载荷试验检验方法及标准请参照河北省工程建设标准《水泥土桩复合地基技术规程》DB 13（J）39-2003。9、对采用夯实水泥土桩加固地基的工程投入使用后定期进行沉降、侧向位移等观测是最直观检验加固效果的理想方法。四、夯实水泥土桩复合地基应符合如下质量体系，见下表。夯实水泥土桩复合地基质量标准/序号检查项目允许偏差或允许值检查方法单位数值主控项目1桩径毫米-20用钢尺量2桩长毫米+500测桩孔深度3桩体干密度设计要求现场取样检查4地基承载力设计要求按规定方法一般项目1土料有机含量%≤5陪烧法2含水率：最优含水率%±2烘干法3土料粒径毫米≤20筛分法4水泥质量设计要求抽样送检5桩位偏差满堂布桩≤0.40D条基布桩≤0.25D用钢尺量D为桩径6桩孔垂直度%≤1.5经纬仪测桩管7褥垫层夯填度≤0.9用钢尺量 [1]安全措施播报编辑采用《夯实水泥土桩处理软基施工工法》施工时，除应执行国家、地方的各项安全施工的规定外，尚应遵守注意下列事项：一、严格执行OHSAS18000职业健康安全管理体系标准，建立健全安全保障体系，明确安全生产责任。二、严格执行安全技术措施审批制度、安全技术交底制度、安全检查制度。三、严格执行安全技术操作规程，机械人员必须培训合格、持证上岗，非专业人员禁止操作机械。机械故障后及时检修，杜绝带病作业。四、操作工人进入现场必须佩戴安全帽及必要的劳保用具。所有现场作业人员严禁酒后上岗。五、成桩过程中冲击锤6米范围内部得有人员走动或其他作业，预防机械倾倒或锤头下落造成人员伤害和机械损坏。六、已成孔尚未夯填水泥土前应加盖板避免人员或物件掉入孔内。七、施工现场的一切电源、电路的安装和拆除必须由专业电工操作，一闸一盒，使用漏电保护器。八、制定安全事故应急预案，事故发生时应保护好现场，及时施救防止事故扩大，及时上报并做好事故后妥善处理。 [1]环保措施播报编辑《夯实水泥土桩处理软基施工工法》的环保措施如下：一、环境保护坚持“以人为本，保持可持续发展”的原则，遵守国家有关环保方面的法律法规及地方有关规定，建立环境保护的规章制度，对施工人员进行环保教育和学习，提高环保意识。二、运输水泥过程中药防止散落，行驶便道防止扬尘。三、施工机械要尽量减少噪声、废气的污染；施工场地的噪声应符合《建筑施工场地界噪声限值》的规定。四、施工机械现场维修时严禁机油漏滴于地表，造成土壤污染。五、施工现场的水泥袋及生活垃圾要集中定点管理，妥善处理，防止造成新的污染源。六、施工完成后，对施工、生活临时占地要尽量恢复原貌，保持水土流失。 [1]效益分析播报编辑《夯实水泥土桩处理软基施工工法》的效益分析如下：夯实水泥土桩混合料采用水泥和土，造价低廉，较其他处理方法（粉喷桩、水泥搅拌桩、碎石桩等）节省费用20%~50%。见下表。效益分析表序号1234工程项目夯实水泥土桩粉喷桩水泥搅拌桩CFG桩每延米单价（元）23293251该处理方法工期短、无环境噪声污染，对水、电条件要求不高，螺旋钻施工可用于各种土质，施工工艺也比较简单且成孔效率高，一经推出，便被广大设计人员及建设方接受，在工程建设中广泛采用。另外，夯实水泥土桩用土采用地表原状土可节约土地资源，保护耕地达到保护生态的目的，同时减少土方运输及运输污染。施工进度快，造价较低，具有社会和经济效益。 [1]注：施工费用以2009-2010年施工材料价格计算应用实例播报编辑《夯实水泥土桩处理软基施工工法》的应用实例如下：一、保沧高速公路保定段全线采用夯实水泥土桩，于2004年开工至2005年底完成施工，通过7、8标两种方案的对比，在质量、工期、成本等方面取得较大优势，经济性优于水泥搅拌桩，共节省资金90~100万元，处理效果良好。二、河北省大广高速公路京衡段全线不连续地分布大量软土、软弱土，物理力学指标一般为w=31.1%~42.9%，e=0.911~1.258，IL=0.69~1.63，a1-2=0.32~1.15。特点是天然含水量较大，孔隙比较大，为高压缩性土，地基土容许承载力底，大部分需进行地基处理。对于软土或软弱土埋藏较深或厚度较大的桥头路基段落及箱形基础下部，处理深度不大于10米且在水位以上的采用夯实水泥土桩进行处理，以提高软土地基承载能力，较少地基沉降量。全线夯实水泥土桩在2009年完成，经单桩和复合地基承载力检测，均满足设计要求。三、荣乌高速公路保定段（徐水至涞源与山西省交界处）是河北省“五纵六横七条线”高速公路网的组成部分。保定市界内建设129.87千米（包括与张石高速公路共线9千米），途径徐水、满城、易县、涞源四县，估算总投资106.6亿该项目东接已建的荣乌高速公路天津至保定段及京港澳国家高速公路，西接山西省拟建的灵丘至山阴段，并在涞源和徐水与在建的张石高速公路相接，构成山西北部与内蒙南部地区最便捷的出海通道，在国家和区域路网中居于重要地位。荣乌高速公路保定段3、4合同采用该工法对原地面进行了软基处理，经过实践应用证明该类桩施工质量比较容易控制，工艺简单，造价方面比其他类桩成本较低。从使用结果看，软土路基加固后，路基稳定，没有发生超限沉降等病害，使用可靠。四、河北省沿海高速公路秦皇岛至冀津界段为秦、唐、沧环渤海公路的一部分，是2020年河北省高速公路布局规划“五纵、六横、七条线主骨架中“横三”的重要组成部分，它与京秦高速、唐港高速、唐曹高速、唐津高速以及国省干道102、205相连接，是沟通沿海地区的主要通道，它连接了沿海的秦皇岛、唐山、曹妃甸、天津滨海新区，对临海产业带的形成具有重要意义，尤其是中国国家重点项目曹妃甸建港工程的上马，使得沿海高速公路的建设更为重要。沿海高速公路秦皇岛至冀津界段起自京秦高速公路北戴河服务区，跨滦河、跨唐港高速公路，止于天津海滨大道，采用低路基设计，设计标准为双向四车道，路基宽度28米，设计行车速度120千米/小时，全封闭、全立交，路线全长160.236千米。夯实水泥土桩处理软基施工技术在沿海高速公路7、8合同路基工程中得到应用。经研究发现夯实水泥土桩施工质量易控制，工程效果良好，夯实水泥土桩较水泥搅拌桩桩体强度更高、成本更低，应用该施工技术能够提高施工质量，降低设备的消耗，减少工程造价，产生经济效益。因此，夯实水泥土桩施工技术是一种经济实用的地基处理方法。 [1]注：施工费用以2009-2010年施工材料价格计算荣誉表彰播报编辑2011年9月30日，中华人民共和国住房和城乡建设部审定《2009-2010年度国家二级工法名单》，以建质[2011]154号文件公布，《夯实水泥土桩处理软基施工工法》被评定为中国国家二级工法。 [2]新手上路成长任务编辑入门编辑规则本人编辑我有疑问内容质疑在线客服官方贴吧意见反馈投诉建议举报不良信息未通过词条申诉投诉侵权信息封禁查询与解封©2024 Baidu 使用百度前必读 | 百科协议 | 隐私政策 | 百度百科合作平台 | 京ICP证030173号京公网安备110000020000

中国红客联盟详细介绍

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主页网络安全中国红客联盟详细介绍

中国红客联盟详细介绍

鹿客山人

十二月 21, 2021

中国红客网络技术联盟简介中国红客网络技术联盟全称为中国红客网络技术联盟，英文名为Honker Union of China（HUC）。简称为红客联盟（红盟）。Lion，中文名林勇，是中国红客联盟（HUC）的创始人。于2000年年底，LION牵头组建了“中国红客联盟”。2009年9月22日，在上海举办的COG2011信息安全论坛被称为“中国黑帽子大会”，现场评选出COG信息安全终身成就奖等4个奖项，Lion林勇获得了COG信息安全社会影响力奖。2011年9月23日，“中国黑帽子大会”的COG2011信息安全论坛在上海召开，前红客联盟创始人Lion（微博）在闭幕词中宣布将重组红客联盟。宗旨红客联盟（红盟）的宗旨是：团结协作、务实创新。目标1）红客联盟（红盟）的近期目标是：提升成员的计算机水平，增强国内网络安全意识，发布与网络安全知识相关的文档，公布最新的系统漏洞以及发布补丁等。2）红客联盟（红盟）的长期目标是：推动计算机技术的发展，探索并涉足计算机技术的未来。历史发展起源红客起源于1999年的五八事件，在美国炸中国驻南联盟大使馆后，一些中国黑客建立了名为中国红客联盟（HUC）的联盟。组织成员利用联合的黑客技能，出于爱国主义和民族主义的表达，向一些美国网站，尤其是政府网站，发动攻击。发起人“中国红客联盟”成立于2000年12月31日，由lion建立。2004年12月31日，创始人LION突然发布了一封公开信，宣称“中国红客联盟”已经名存实亡，没有存在的必要。随后，中国红客网站关闭，7名核心成员在网络世界中消失。2005年，中国红客联盟重新组建，一个月后解散。2008年8月25日，红盟再度组建，默默支持奥运会的正常举办。2009年，中国红客联盟重新开站。2011年9月22日，宣布重新组建，新网站于2011年11月1日开放。网址以及首页中国红客联盟-老牌黑客组织,学技术就上红客网,全是技术帖. (chinesehongker.com)道，可道，非常道；名，可名，非常名。—— 老子《道德经》相关网站中国红客联盟(ihonker.org)由08sec于2015年3月重组。

本站与网络上的中国红客联盟无任何关系，但我们拥有同样的精神，一种热爱祖国、坚持正义、开拓进取的精神。08sec（08 Security Team）是一个由计算机技术爱好者自发组织成立的非营利性的研究机构，专注于网络信息安全领域，倡导健康的中国信息安全文化。

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联盟简介

中国红客联盟

中国红客联盟，又叫H.U.C，全称：“中国红客网络安全技术联盟”，简称“红客联盟”、“红盟”，英文“Honker Union of China ”，简称：“HUC”。由中国多个黑客组织、无名黑客成员、计算机爱好者组成，因“中美黑客大战”一战成名。

联盟由来

“红客”起源于1999年的五八事件，在美国炸中国驻南联盟大使馆后，一些中国黑客建立了一个联盟名为中国红客联盟(HUC)。组织成员利用联合的黑客技能，为表达爱国主义和民族主义，向一些美国网站，特别是政府网站，发出攻击。

2000年，中国黑客们以组织及个人名誉成立红客、红客联盟、红客大联盟等红客网站。

2004年，某红客联盟网站因个人原因宣布解散。

2005年，红客成员自发成立多个红客及红客联盟名称网站。

2008年，奥运护网原红客成员王子重组中国红客联盟网站。

2008年，部分2005年红客成员成立的红客网站部分关闭。

2009年，1月1日王子（中国红客联盟）网站对外宣布重组中国红客联盟。

2010年，王子网站开除成员网名冰儿成立自己的红盟网站。

2011年，04年红客联盟解散站长宣称重新开站。

2015年，某技术成员成立自己的红客联盟网站。

联盟性质

红客联盟（红盟）是一个非商业性的民间技术机构。主要由爱好计算机爱好者组成。进行有计划有组织的计算机技术方面的研究、交流、整理、和推广工作。同时，红客联盟（红盟）是一个民间的爱国团体，我们不参与政治，我们的一切言论和行动都建立在爱国和维护中国尊严的基础上，我们的声音和行动是中华民族气节的体现。

联盟文化

宗旨：

红客联盟（红盟）的宗旨是：团结协作、务实创新。

目标

1、红客联盟（红盟）的近期目标是：提高成员的计算机水平，提高国内的网络安全意识，发布有关于网络安全知识的相关文档，公布最新的系统漏洞以及发布补丁等。

2、红客联盟（红盟）的长期目标是：希望能推动计算机技术的发展，探索和涉足计算机技术的未来。

联盟纪律

1、任何红客联盟成员或其他个人不得以红客联盟组织名义或者以红客联盟成员名义发布公告、政治性言论、反动言论等；红客联盟承诺不会对国内站点实施攻击，任何红客联盟成员或其他个人不得以红客联盟组织名义或者以红客联盟成员名义对国内站点和网络实施攻击；任何使用有关红客联盟组织名义或者红客联盟成员名义实施破坏、假冒、反动等损害红客联盟组织形象的行为，红客联盟将予以追查，并保留法律追诉权利。

2、成员不得以组织的名义从事违法、有损公共道德或以满足个人利益为目的活动。如有违反，后果一切自负，红客联盟保留法律追诉权利。

3、成员不得利用自身的技术进行危害网络安全的行为，不得违反国家关于网络安全方面的法律法规。任何人不得以任何名义对任何国内合法站点进行任何形式的攻击。如有违反，取消其成员资格，后果一切自负，红客联盟保留法律追诉权利。

4、成员不得以联盟的名义或利用联盟的网站、邮箱、论坛、聊天室、服务器、QQ群、微信群等自媒体以及一切联盟提供的交流场所和手段，发表政治性言论、对他人进行攻击、进行有悖伦理道德的活动或用作商业用途，红客联盟保留法律追诉权利。

5、成员应当本着团结协作的宗旨，相互帮助，对于成员提出的技术问题，了解情况的应当积极的给予答复。

6、成员不得参与其他的同类的组织和团体，但允许进行互相的技术交流。

第二代混合超级电容器成功诞生-行业动态-〔烯晶碳能 ― 中国高品质法拉电容器领创者〕

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第二代混合超级电容器成功诞生

超级电容器是指介于传统电容器和充电电池之间的一种新型储能装置，它既具有电容器快速充放电的特性，同时又具有电池的储能特性。近日，365光伏记者获悉，GMCC研发的混合超级电容器HUC（Hybrid UltraCapacitor）日前成功完成量产测试，这标志着第二代混合超级电容器成功诞生！众所周知，与传统二次电池相比,超级电容器具有长寿命、高功率密度的特点,但能量密度较低是其一直以来难以克服的技术瓶颈。GMCC开发的混合超级电容器HUC（Hybrid UltraCapacitor）完美融合超级电容器和锂离子电池的特点，同时具备高能量密度和高功率密度的双重优势，能量密度80-160Wh/kg、功率密度6-12kW/kg，充放电倍率30-150C，并解决了锂离子电池的低温充放电能力和安全性问题，成功实现-35摄氏度10C放电。得益于引入了超级电容器的科学原理，构建新型材料体系，混合超级电容器的寿命相比锂离子电池可大幅提升到5万次以上，如上图所示，GMCC 6Ah HUC在室温、100% DOD和10C/10C 充放电倍率的条件下已经循环25000次，容量保持率85%。HUC的成功开发，解决超级电容器能量密度低的缺陷，解决了锂离子电池功率密度低、充放电倍率低的问题，保持了低内阻、长寿命、宽温域（-40―65℃）的性能优势，极大地拓宽了应用场景。HUC可广泛应用于电力储能领域。近期，GMCC成功中标德国某电力巨头50MW 调频项目，该项目基于超级电容器储能可以实现有功支撑、无功支撑、谐波治理、虚拟同步以及电压暂降治理等功能。HUC储能系统“毫秒级响应”速度，“在秒级――分钟级”需求场景具有高性价比、高安全性、宽温度范围等明显优势，对提高新能源接入质量，电网的安全稳定运行，用电质量的保障起重要作用。目前，烯晶碳能14Ah混合超级电容器产品还通过了欧洲某超级跑车客户的苛刻实验验证，可持续7分钟纽伦堡赛道工况，获得了项目定点。同时，烯晶碳能6Ah混合超级电容器还作为ADAS智能驾驶冗余电源被某豪华车选中，备份高可靠12V第二电源，即将搭载50余万辆乘用车。据了解，烯晶碳能电子科技无锡有限公司是一家功率型储能器件专业研究与制造商，在电化学、活性材料、制备工艺方面持续研发十多年，技术底子扎实，以顶级的干法电极产业化工艺和性能领先的超级电容器产品闻名全球。早在2019年，烯晶碳能的车规级超级电容器在红旗H5/H9、Volvo-XC40、捷豹路虎等车型实现批量化应用。全球多家知名零部件供应商相继授权GMCC为超级电容器定点供应商，产品被广泛应用于知名品牌乘用车、商用车，引领了全球超级电容器高性能发展。混合超级电容器（HUC）的成功开发、乘用车项目定点的成功获取及德国电力巨头50MW调频项目的顺利中标，引领了全球超级电容器领域的研发创新，同时也为超级电容器行业的发展注入了全新活力。

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HuC/HuD Monoclonal Antibody (16A11) (A-21271)

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Primary Antibodies

›

HuC/HuD Antibodies

Invitrogen

HuC/HuD Monoclonal Antibody (16A11)

490 References

View all (2) HuC/HuD antibodies

Datasheet

Protocols

Tech Support

Cite HuC/HuD Monoclonal Antibody (16A11)

The following product was used in this experiment: HuC/HuD Monoclonal Antibody (16A11) from Thermo Fisher Scientific, catalog # A-21271, RRID AB_221448.

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HuC/HuD Antibody (A-21271) in IHC (F)

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The spinal cord, dorsal root ganglia and sympathetic ganglia from the brachial region of a chick cryosection at stage 23 (Hamburger and Hamilton numbering) were identified with the mouse monoclonal anti-human neuronal protein HuC/HuD antibody (Product # A-21271) and visualized with fluorescein-labeled goat anti-mouse IgG antibody (Product # F-2761). The primary antibody recognizes an antigen localized to neuronal cell bodies and is ideal for identifying and counting neurons in both early and late development. Human, mouse, avian and zebrafish tissues have all demonstrated similar neuron-specific labeling patterns. Image contributed by Michael Marusich, Monoclonal Antibody Facility, University of Oregon, Eugene, Oregon.

Immunofluorescent analysis of HuC/D (green) and MAP2 (red) on rat primary cortical neurons cultured for 28 days in the B-27 Plus Neuronal Culture System (Product # A3653401). At day 28 the cells were fixed with 4% paraformaldehyde for 15 min, permeabilized with 0.1% triton x-100 for 30min, and blocked with 1% BSA for 30 min at room temperature. Cells were stained with anti-HuC/D antibody (Product # A-21271) at a dilution of 1:250, and anti-MAP2 (Product # PA5-17646) at a dilution of 1:250, in 1% BSA staining buffer, overnight at 4C, and then incubated with Alexa Fluor 488 conjugated donkey anti-mouse (Product # A-21202) and Alexa Fluor 594 donkey anti-rabbit (Product # A-21207) antibodies at a dilution of 1:1000 for 30 min. at room temp. Wash 3 times with DPBS. Stain with DAPI for nucleus. Images were taken on a Thermo Fisher Scientific EVOS M5000 Cell Imaging System at 10x magnification.

Immunofluorescent analysis of HuC/HuD in the differentiated neurons from H9 ESC-derived NSCs. 2 weeks after differentiation, cells were fixed, permeabilized and stained with a MAP2 rabbit polyclonal antibody (Product # PA5-17646) at 1:100 dilution (green) and a HuC/HuD mouse monoclonal antibody (Product # A-21271), at a concentration of 5 µg/mL (red) in blocking buffer for at least 1 hour at room temperature, and then incubated with goat anti-rabbit IgG secondary antibody, Alexa Fluor Plus 488 conjugate (Product # A32731, green) and a donkey anti-mouse IgG secondary antibody, Alexa Fluor 594 conjugate (Product # A-21203, red) at a dilution of 1:1000 for 1 hour at room temperature. Nuclei (blue) were stained with Hoechst 33342 dye (Product # 62249).

Cultured axolotl sensory neurons stained with our anti-human neuronal protein HuC/HuD antibody (anti-Hu, Product # A-21271) and detected using the red-orange-fluorescent Alexa Fluor® 546 goat anti-mouse IgG antibody (Product # A-11003). Actin was labeled using green-fluorescent Alexa Fluor® 488 phalloidin (Product # A12379) and nuclei were stained with blue-fluorescent Hoechst 33342 (Product # H1399, H3570, H21492). The image was contributed by Josh Gross and Linda Barlow, University of Denver, Denver, Colorado.

Neuronal cells in a 22-hour zebrafish embryo were identified with anti-HuC/HuD mouse monoclonal antibody (Product # A-21271) and visualized with red-orange-fluorescent Alexa Fluor® 568 goat anti-mouse IgG antibody (Product # A-11004). The nuclei were stained with blue-fluorescent DAPI (Product # D1306, D3571, D21490).

Reduced background staining afforded by Image-iT® FX signal enhancer. Mouse brain cryosections were permeabilized and antigen retrieval was carried out. The sections were then treated for 30 minutes with Image-iT® FX signal enhancer (Product # I36933, left) or left untreated (right). Sections were labeled with the neural cell body selective antibody anti-Hu C/D (Product # A-21271) and visualized using TSA Kit #2 (Product # T-20912) with the HRP conjugate of goat anti-mouse IgG and Alexa Fluor® 488 tyramide. Sections were mounted using the reagents in the ProLong® Antifade Kit (Product # P-7481).

Product Details

A-21271

Applications

Tested Dilution

Publications

Western Blot

(WB)

1-5 µg/mL

View 13 publications

13 publications

Immunohistochemistry

(IHC)

View 302 publications

302 publications

Immunohistochemistry (Paraffin)

(IHC (P))

View 24 publications

24 publications

Immunohistochemistry (PFA fixed)

(IHC (PFA))

View 2 publications

2 publications

Immunohistochemistry (Frozen)

(IHC (F))

5-20 µg/mL

View 39 publications

39 publications

Immunohistochemistry - Free Floating

(IHC (Free))

View 6 publications

6 publications

Immunocytochemistry

(ICC/IF)

5-20 µg/mL

View 60 publications

60 publications

Flow Cytometry

(Flow)

View 1 publication

1 publication

ELISA

(ELISA)

View 1 publication

1 publication

Functional Assay

(FN)

View 1 publication

1 publication

Miscellaneous PubMed

(Misc)

View 41 publications

41 publications

Product Specifications

Species Reactivity

Avian,

Chicken,

Human,

Zebrafish

Published species

Avian,

Cat,

Chicken,

Chimpanzee,

Fish,

Guinea pig,

Horse,

Human,

Lizard,

Mouse,

Non-human primate,

Pig,

Rabbit,

Rat,

Reptile,

Rhesus monkey,

Rodent,

Shark,

Sheep,

Xenopus,

Zebrafish

Host/Isotype

Mouse

/ IgG2b, kappa

Class

Monoclonal

Type

Antibody

Clone

16A11

Immunogen

Human HuC/HuD neuronal protein.

Conjugate

Unconjugated

View additional formats

Biotin

Form

Lyophilized

Purification

purified

Contains

no preservative

Storage conditions

-20°C

Shipping conditions

Ambient

RRID

AB_221448

Product Specific Information

This antibody recognizes the Elav family members HuC, HuD and Hel-N1 neuronal proteins. It does not recognize HuR, another Elav family member that is present in all proliferating cells. The antibody has been shown to specifically label neuronal cells in zebrafish, chick, canaries, and humans, and is likely to label neuronal cells in most vertebrate species. Labeling is visible early in development, at about the time that the neurons leave the mitotic cycle.Storage and reconstitution: Upon receipt, lyophilized antibodies should be stored desiccated at -20ºC or lower. When properly stored, these products are stable for at least one year. To prepare stock solution, reconstitute the antibody in 0.5-1 mL PBS, pH 7.4, containing 1% BSA. Store the solution for up to two weeks at 4ºC with the addition of 2mM sodium azide. For longer storage, divide solutions into single-use aliquots and freeze at -20ºC, avoidig freeze/thaw cycles.For best results in immunohistochemistry, antigen retrieval is required. Use 50mM Tris, pH 8.0, for 30 minutes.A-21271 was successfully used to detect HuC/HuD in neurons differentiated from H9 ESC derived NSCs.

Target Information

Anti-Hu antibodies were originally isolated from a patient with paraneoplastic encephalomyelitis, a rare condition of selective neural tissue injury associated with small cell lung carcinoma. The antibodies bind specifically to antigens present exclusively in neuronal cells and are thus useful as markers of neuronal cells in tissue. The Hu antigen is an RNA-binding protein of the embryonic lethal abnormal visual (Elav) family.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Amyotrophic lateral sclerosis with TDP-43 abnormalities exhibiting globular glial tau inclusions in frontotemporal lobes and pallido-nigral system.

Neuropathology : official journal of the Japanese Society of Neuropathology

Yagita K,Sasagasako N,Koyama S,Noguchi H,Honda H

A-21271 was used in Immunohistochemistry to present the autopsy case of an 80-year-old woman with a 9-year history of motor neuron disease and atypical Parkinsonism.

Wed Feb 01 00:00:00 EST 2023

Glyphosate affects the neurochemical phenotype of the intramural neurons in the duodenum in the pig.

Neurogastroenterology and motility

Palus K,Bulc M,Całka J

A-21271 was used in Immunohistochemistry-immunofluorescence to determine the effect of glyphosate intoxication on the neurochemical properties of the enteric nervous system (ENS) neurons located in the wall of the porcine duodenum.

Wed Mar 01 00:00:00 EST 2023

Increasing astrogenesis in the developing hippocampus induces autistic-like behavior in mice via enhancing inhibitory synaptic transmission.

Glia

Chen J,Ma XL,Zhao H,Wang XY,Xu MX,Wang H,Yang TQ,Peng C,Liu SS,Huang M,Zhou YD,Shen Y

A-21271 was used in Immunohistochemistry to provide direct evidence for a developmental role of astrocytes in driving the behavioral phenotypes of ASD.

Sat Jan 01 00:00:00 EST 2022

Response of Olfactory Sensory Neurons to Mercury Ions in Zebrafish: An Immunohistochemical Study.

Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada

Lazzari M,Bettini S,Milani L,Maurizii MG,Franceschini V

A-21271 was used in Immunohistochemistry to conclude that the differential results between dorsal and ventral halves of the olfactory rosette could derive from different water flows inside the olfactory chamber or different subpopulations in OSNs.

Tue Feb 01 00:00:00 EST 2022

Transduction of Systemically Administered Adeno-Associated Virus in the Colonic Enteric Nervous System and c-Kit Cells of Adult Mice.

Frontiers in neuroanatomy

Wang L,Yuan PQ,Challis C,Ravindra Kumar S,Taché Y

A-21271 was used in Immunohistochemistry-immunofluorescence to demonstrate that in adult mice colon that there is a rostro-caudal decrease in the transduction of systemic delivery of AAV9 and its variants independent of sex.

Sat Jul 16 00:00:00 EDT 2022

Semaphorin 4D is upregulated in neurons of diseased brains and triggers astrocyte reactivity.

Journal of neuroinflammation

Evans EE,Mishra V,Mallow C,Gersz EM,Balch L,Howell A,Reilly C,Smith ES,Fisher TL,Zauderer M

A-21271 was used in Immunohistochemistry to suggest that SEMA4D blockade may ameliorate disease pathology by preserving normal astrocyte function and reducing the negative consequences of reactive astrogliosis.

Sat Aug 06 00:00:00 EDT 2022

Banp regulates DNA damage response and chromosome segregation during the cell cycle in zebrafish retina.

eLife

Babu S,Takeuchi Y,Masai I

A-21271 was used in Immunohistochemistry to report that Btg3-associated nuclear protein is indispensable for the DNA damage response and chromosome segregation during mitosis.

Tue Aug 09 00:00:00 EDT 2022

Normal aging, motor neurone disease, and Alzheimer's disease are characterized by cortical changes in inflammatory cytokines.

Journal of neuroscience research

Tennakoon A,Katharesan V,Musgrave IF,Koblar SA,Faull RLM,Curtis MA,Johnson IP

A-21271 was used in Immunocytochemistry to report that healthy aging and age-related neurodegenerative diseases have different cortical inflammatory signatures that are characterized by increased levels of anti-inflammatory cytokines.

Tue Feb 01 00:00:00 EST 2022

Voltage-gated sodium channel scn8a is required for innervation and regeneration of amputated adult zebrafish fins.

Proceedings of the National Academy of Sciences of the United States of America

Osorio-Méndez D,Miller A,Begeman IJ,Kurth A,Hagle R,Rolph D,Dickson AL,Chen CH,Halloran M,Poss KD,Kang J

A-21271 was used in Immunohistochemistry-immunofluorescence to indicate that the activity of VGSCs plays a proregenerative role by promoting innervation of appendage stumps.

Tue Jul 12 00:00:00 EDT 2022

Dopaminergic Positron Emission Tomography Imaging in the Alpha-Synuclein Preformed Fibril Model Reveals Similarities to Early Parkinson's Disease.

Movement disorders : official journal of the Movement Disorder Society

Sossi V,Patterson JR,McCormick S,Kemp CJ,Miller KM,Stoll AC,Kuhn N,Kubik M,Kochmanski J,Luk KC,Sortwell CE

A-21271 was used in Immunohistochemistry to investigate multiple aspects of in vivo dopaminergic deficits longitudinally and similarities to human PD using translational PET imaging readouts.

Mon Aug 01 00:00:00 EDT 2022

Asymmetric Notch activity by differential inheritance of lysosomes in human neural stem cells.

Science advances

Bohl B,Jabali A,Ladewig J,Koch P

A-21271 was used in Immunocytochemistry to demonstrate that in human neural stem cells (NSCs), lysosomes are asymmetrically inherited during mitosis.

Fri Feb 11 00:00:00 EST 2022

Embryonic ethanol exposure induces ectopic Hcrt and MCH neurons outside hypothalamus in rats and zebrafish: Role in ethanol-induced behavioural disturbances.

Addiction biology

Collier AD,Yasmin N,Chang GQ,Karatayev O,Khalizova N,Fam M,Abdulai AR,Yu B,Leibowitz SF

A-21271 was used in Immunohistochemistry-immunofluorescence to suggest that the ectopic peptide neurons are functional and contribute to the ethanol-induced behavioural disturbances related to the overconsumption of alcohol.

Tue Nov 01 00:00:00 EDT 2022

G9a dictates neuronal vulnerability to inflammatory stress via transcriptional control of ferroptosis.

Science advances

Rothammer N,Woo MS,Bauer S,Binkle-Ladisch L,Di Liberto G,Egervari K,Wagner I,Haferkamp U,Pless O,Merkler D,Engler JB,Friese MA

A-21271 was used in Immunohistochemistry-immunofluorescence to identify G9a as a critical transcriptional enhancer of neuronal ferroptosis and potential therapeutic target to counteract inflammation-induced neurodegeneration.

Fri Aug 05 00:00:00 EDT 2022

A New Transgenic Tool to Study the Ret Signaling Pathway in the Enteric Nervous System.

International journal of molecular sciences

Bandla A,Melancon E,Taylor CR,Davidson AE,Eisen JS,Ganz J

A-21271 was used in Immunohistochemistry-immunofluorescence to find that EPCs and the majority of ENS neurons express ret:GFP during ENS development.

Sat Dec 10 00:00:00 EST 2022

Role of mTORC1 activity during early retinal development and lamination in human-induced pluripotent stem cell-derived retinal organoids.

Cell death discovery

Lee SH,Han JW,Yang JY,Jun HO,Bang JH,Shin H,Choi JH,Lee J,Madrakhimov SB,Chung KH,Chang HS,Lyu J,Park TK

A-21271 was used in Immunohistochemistry to identify the time-dependent role of mTORC1 in retinal development, specifically in retinal ganglion cell (RGC) differentiation and the retinal lamination process, during the early stages of retinal organoid (RO) development.

Tue Feb 08 00:00:00 EST 2022

DARPP-32 distinguishes a subset of adult-born neurons in zebra finch HVC.

The Journal of comparative neurology

Aronowitz JV,Kirn JR,Pytte CL,Aaron GB

A-21271 was used in Immunohistochemistry-immunofluorescence to demonstrate and characterize that half of all HVC NNs in zebra finches express DARPP32, receive catecholaminergic input and have transiently larger nuceli than the other half.

Fri Apr 01 00:00:00 EDT 2022

Effects of exercise on muscle reinnervation and plasticity of spinal circuits in rat sciatic nerve crush injury models with different numbers of crushes.

Muscle & nerve

Minegishi Y,Nishimoto J,Uto M,Ozone K,Oka Y,Kokubun T,Murata K,Takemoto H,Kanemura N

A-21271 was used in Immunohistochemistry to examine how different numbers of crushes of the rat sciatic nerve affects muscle reinnervation and plasticity of spinal circuits and the effect of exercise intervention.

Sun May 01 00:00:00 EDT 2022

Quantification of CGRP-immunoreactive myenteric neurons in mouse colon.

The Journal of comparative neurology

Hibberd TJ,Yew WP,Dodds KN,Xie Z,Travis L,Brookes SJ,Costa M,Hu H,Spencer NJ

A-21271 was used in Immunohistochemistry-immunofluorescence to conclude that CGRP+ myenteric neurons in mouse colon were comprehensively quantified, occurring within a range expected of a putative IPAN marker.

Thu Dec 01 00:00:00 EST 2022

Quantification of CGRP-immunoreactive myenteric neurons in mouse colon.

The Journal of comparative neurology

Hibberd TJ,Yew WP,Dodds KN,Xie Z,Travis L,Brookes SJ,Costa M,Hu H,Spencer NJ

Thu Dec 01 00:00:00 EST 2022

Quantification of CGRP-immunoreactive myenteric neurons in mouse colon.

The Journal of comparative neurology

Hibberd TJ,Yew WP,Dodds KN,Xie Z,Travis L,Brookes SJ,Costa M,Hu H,Spencer NJ

Thu Dec 01 00:00:00 EST 2022

Quantification of CGRP-immunoreactive myenteric neurons in mouse colon.

The Journal of comparative neurology

Hibberd TJ,Yew WP,Dodds KN,Xie Z,Travis L,Brookes SJ,Costa M,Hu H,Spencer NJ

Thu Dec 01 00:00:00 EST 2022

Whole gut imaging allows quantification of all enteric neurons in the adult zebrafish intestine.

Neurogastroenterology and motility

El-Nachef WN,Hu C,Bronner ME

A-21271 was used in Immunohistochemistry to study the enteric neurons within the adult zebrafish intestine and assess the relationship between intestinal length and total enteric neuron number.

Tue Feb 01 00:00:00 EST 2022

Mutations in Hcfc1 and Ronin result in an inborn error of cobalamin metabolism and ribosomopathy.

Nature communications

Chern T,Achilleos A,Tong X,Hill MC,Saltzman AB,Reineke LC,Chaudhury A,Dasgupta SK,Redhead Y,Watkins D,Neilson JR,Thiagarajan P,Green JBA,Malovannaya A,Martin JF,Rosenblatt DS,Poché RA

A-21271 was used in Immunohistochemistry to identify HCFC1/RONIN as transcriptional regulators of ribosome biogenesis during development and their mutation results in complex syndromes exhibiting aspects of both cblC and ribosomopathies.

Mon Jan 10 00:00:00 EST 2022

Electroacupuncture at Acupoint ST36 (Zusanli) Improves Intestinal Motility Dysfunction Via Increasing the Proportion of Cholinergic Neurons in Rat Ileal Myenteric Ganglia after Severe Acute Pancreatitis.

Evidence-based complementary and alternative medicine : eCAM

Wang X,Lu L,Zi L,Hu H,Li H,He Y,Li N,Wen Q

A-21271 was used in Immunohistochemistry-immunofluorescence to suggest that EA stimulation at ST36 can partly restore the enteric neuron function and improve intestinal motility dysfunction, therefore could ameliorate SAP. The enteric nervous system can participate in changes in intestinal motility by affecting cholinergic neurons.

Wed Nov 02 00:00:00 EDT 2022

Myostatin is a negative regulator of adult neurogenesis after spinal cord injury in zebrafish.

Cell reports

Saraswathy VM,Zhou L,McAdow AR,Burris B,Dogra D,Reischauer S,Mokalled MH

A-21271 was used in Immunohistochemistry to investigate mechanisms of axon regrowth in spinal cord regeneration of zebrafish.

Tue Nov 22 00:00:00 EST 2022

Cre/lox regulated conditional rescue and inactivation with zebrafish UFlip alleles generated by CRISPR-Cas9 targeted integration.

eLife

Liu F,Kambakam S,Almeida MP,Ming Z,Welker JM,Wierson WA,Schultz-Rogers LE,Ekker SC,Clark KJ,Essner JJ,McGrail M

A-21271 was used in Immunohistochemistry-immunofluorescence to validate a simplified approach for efficient isolation of Cre/lox-responsive conditional alleles in zebrafish.

Fri Jun 17 00:00:00 EDT 2022

A new transgenic reporter line reveals expression of protocadherin 9 at a cellular level within the zebrafish central nervous system.

Gene expression patterns : GEP

Habicher J,Manuel R,Pedroni A,Ferebee C,Ampatzis K,Boije H

A-21271 was used in Immunohistochemistry to generate a transgenic zebrafish reporter line for pcdh9, detecting the molecule in a portion of internurons within spinal locomotor network.

Wed Jun 01 00:00:00 EDT 2022

Reactivation of the Neurogenic Niche in the Adult Zebrafish Statoacoustic Ganglion Following a Mechanical Lesion.

Frontiers in cell and developmental biology

Schwarzer S,Rekhade DR,Machate A,Spieß S,Geffarth M,Ezhkova D,Hans S

A-21271 was used in Immunohistochemistry to show that the neurogenic niche of the adult zebrafish SAG can be reactivated to re-enter the cell cycle and to increase neurogenesis upon lesion.

Tue Apr 05 00:00:00 EDT 2022

Embryonic alcohol exposure disrupts the ubiquitin-proteasome system.

JCI insight

Weeks O,Miller BM,Pepe-Mooney BJ,Oderberg IM,Freeburg SH,Smith CJ,North TE,Goessling W

A-21271 was used in Immunohistochemistry to identify the proteasome as a target of EtOH exposure and signify that UPS disruptions contribute to craniofacial, neurological, and endodermal phenotypes in FASDs.

Thu Dec 08 00:00:00 EST 2022

An early cell shape transition drives evolutionary expansion of the human forebrain.

Cell

Benito-Kwiecinski S,Giandomenico SL,Sutcliffe M,Riis ES,Freire-Pritchett P,Kelava I,Wunderlich S,Martin U,Wray GA,McDole K,Lancaster MA

A-21271 was used in Immunohistochemistry to study developmental mechanisms driving evolutionary brain expansion using cerebral organdies derived from human, gorilla and chimpanzee cells.

Thu Apr 15 00:00:00 EDT 2021

An early cell shape transition drives evolutionary expansion of the human forebrain.

Cell

Benito-Kwiecinski S,Giandomenico SL,Sutcliffe M,Riis ES,Freire-Pritchett P,Kelava I,Wunderlich S,Martin U,Wray GA,McDole K,Lancaster MA

A-21271 was used in Immunohistochemistry to study developmental mechanisms driving evolutionary brain expansion using cerebral organdies derived from human, gorilla and chimpanzee cells.

Thu Apr 15 00:00:00 EDT 2021

Single-cell transcriptomics of human embryos identifies multiple sympathoblast lineages with potential implications for neuroblastoma origin.

Nature genetics

Kameneva P,Artemov AV,Kastriti ME,Faure L,Olsen TK,Otte J,Erickson A,Semsch B,Andersson ER,Ratz M,Frisén J,Tischler AS,de Krijger RR,Bouderlique T,Akkuratova N,Vorontsova M,Gusev O,Fried K,Sundström E,Mei S,Kogner P,Baryawno N,Kharchenko PV,Adameyko I

A-21271 was used in Immunohistochemistry to examine the transcriptional states of neural crest- and mesoderm-derived lineages differentiating into adrenal glands, kidneys, endothelium and hematopoietic tissue between post-conception weeks 6 and 14 of human development.

Sat May 01 00:00:00 EDT 2021

Biallelic variants in LIG3 cause a novel mitochondrial neurogastrointestinal encephalomyopathy.

Brain : a journal of neurology

Bonora E,Chakrabarty S,Kellaris G,Tsutsumi M,Bianco F,Bergamini C,Ullah F,Isidori F,Liparulo I,Diquigiovanni C,Masin L,Rizzardi N,Cratere MG,Boschetti E,Papa V,Maresca A,Cenacchi G,Casadio R,Martelli P,Matera I,Ceccherini I,Fato R,Raiola G,Arrigo S,Signa S,Sementa AR,Severino M,Striano P,Fiorillo C,Goto T,Uchino S,Oyazato Y,Nakamura H,Mishra SK,Yeh YS,Kato T,Nozu K,Tanboon J,Morioka I,Nishino I,Toda T,Goto YI,Ohtake A,Kosaki K,Yamaguchi Y,Nonaka I,Iijima K,Mimaki M,Kurahashi H,Raams A,MacInnes A,Alders M,Engelen M,Linthorst G,de Koning T,den Dunnen W,Dijkstra G,van Spaendonck K,van Gent DC,Aronica EM,Picco P,Carelli V,Seri M,Katsanis N,Duijkers FAM,Taniguchi-Ikeda M,De Giorgio R

A-21271 was used in Immunohistochemistry to study the effect of reduced ligase III (LIG3) activity and resulting mitochondrial dysfunction in seven patients, who showed the common occurrence of gut dysmotility and neurological manifestations reminiscent of mitochondrial neurogastrointestinal encephalomyopathy.

Tue Jun 22 00:00:00 EDT 2021

Dbnl and β-catenin promote pro-N-cadherin processing to maintain apico-basal polarity.

The Journal of cell biology

Herrera A,Menendez A,Torroba B,Ochoa A,Pons S

A-21271 was used in Functional assay to demonstrate that Dbnl and Drebrin-like β-catenin assist in the maturation of pro-N-cadherin, which is critical for AJ formation and for the recruitment AC components like aPKC and, consequently, for the maintenance of apico-basal polarity.

Mon Jun 07 00:00:00 EDT 2021

A single-plasmid approach for genome editing coupled with long-term lineage analysis in chick embryos.

Development (Cambridge, England)

Gandhi S,Li Y,Tang W,Christensen JB,Urrutia HA,Vieceli FM,Piacentino ML,Bronner ME

A-21271 was used in Immunohistochemistry to investigate a single-plasmid approach for genome editing in chick embryos to study experimentally perturbed cells in an otherwise normal embryonic environment.

Thu Apr 01 00:00:00 EDT 2021

Dissociable Roles of Pallidal Neuron Subtypes in Regulating Motor Patterns.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Cui Q,Pamukcu A,Cherian S,Chang IYM,Berceau BL,Xenias HS,Higgs MH,Rajamanickam S,Chen Y,Du X,Zhang Y,McMorrow H,Abecassis ZA,Boca SM,Justice NJ,Wilson CJ,Chan CS

A-21271 was used in Immunohistochemistry to establish the foundation for future investigations of motor function and disease pathophysiology.

Wed May 05 00:00:00 EDT 2021

Setd1a Plays Pivotal Roles for the Survival and Proliferation of Retinal Progenitors via Histone Modifications of Uhrf1.

Investigative ophthalmology & visual science

Deng X,Iwagawa T,Fukushima M,Suzuki Y,Watanabe S

A-21271 was used in Immunohistochemistry (Frozen) to indicate that Setd1a contributes to the survival and proliferation of retinal cells by regulating histone methylation, Setd1a regulates Uhrf1 expression, and these two molecules cooperate to regulate RPC survival and proliferation.

Mon May 03 00:00:00 EDT 2021

Phosphorylated Tau protein in the myenteric plexus of the ileum and colon of normothermic rats and during synthetic torpor.

Cell and tissue research

Chiocchetti R,Hitrec T,Giancola F,Sadeghinezhad J,Squarcio F,Galiazzo G,Piscitiello E,De Silva M,Cerri M,Amici R,Luppi M

A-21271 was used in Immunohistochemistry to strengthen the hypothesis of a common cellular mechanism triggered by ST, natural hibernation and tauopathies occurring in ENS neurons.

Sat May 01 00:00:00 EDT 2021

Effects of the food additive monosodium glutamate on cisplatin-induced gastrointestinal dysmotility and peripheral neuropathy in the rat.

Neurogastroenterology and motility

López-Tofiño Y,Vera G,López-Gómez L,Girón R,Nurgali K,Uranga JA,Abalo R

A-21271 was used in Immunohistochemistry to test whether MSG may improve gastrointestinal motor dysfunction and other adverse effects induced by repeated cisplatin in rats.

Thu Apr 01 00:00:00 EDT 2021

Cannabinoid and Cannabinoid-Related Receptors in the Myenteric Plexus of the Porcine Ileum.

Animals : an open access journal from MDPI

Toschi A,Galiazzo G,Piva A,Tagliavia C,Mazzuoli-Weber G,Chiocchetti R,Grilli E

A-21271 was used in Immunohistochemistry to immunohistochemically localize the distribution of canonical cannabinoid receptor type 1 (CB1R) and type 2 (CB2R) and the cannabinoid-related receptors transient potential vanilloid receptor 1 (TRPV1), transient potential ankyrin receptor 1 (TRPA1), and serotonin receptor 5-HT1a (5-HT1aR) in the myenteric plexus (MP) of pig ileum.

Thu Jan 21 00:00:00 EST 2021

Peculiar protrusions along tanycyte processes face diverse neural and nonneural cell types in the hypothalamic parenchyma.

The Journal of comparative neurology

Pasquettaz R,Kolotuev I,Rohrbach A,Gouelle C,Pellerin L,Langlet F

A-21271 was used in Immunohistochemistry-immunofluorescence to lay the neuroanatomical basis for tanycyte/neural cell interactions, which will be useful to further understand cell-to-cell communications involved in the regulation of neuroendocrine functions.

Mon Feb 01 00:00:00 EST 2021

Developmental delay during eye morphogenesis underlies optic cup and neurogenesis defects in zebrafish mutants.

The International journal of developmental biology

Wycliffe R,Plaisancie J,Leaman S,Santis O,Tucker L,Cavieres D,Fernandez M,Weiss-Garrido C,Sobarzo C,Gestri G,Valdivia LE

A-21271 was used in Immunohistochemistry to study mab21l2 biological function in the developing optic vesicles.

Fri Feb 18 00:00:00 EST 2022

CHAF1A Blocks Neuronal Differentiation and Promotes Neuroblastoma Oncogenesis via Metabolic Reprogramming.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Tao L,Moreno-Smith M,Ibarra-García-Padilla R,Milazzo G,Drolet NA,Hernandez BE,Oh YS,Patel I,Kim JJ,Zorman B,Patel T,Kamal AHM,Zhao Y,Hicks J,Vasudevan SA,Putluri N,Coarfa C,Sumazin P,Perini G,Parchem RJ,Uribe RA,Barbieri E

A-21271 was used in Flow cytometry/Cell sorting to investigate the mechanism by which chromatin assembly factor 1 subunit p150 drives neuroblastoma oncogenesis.

Fri Oct 01 00:00:00 EDT 2021

Sonic Hedgehog receptor Patched deficiency in astrocytes enhances glucose metabolism in mice.

Molecular metabolism

Tirou L,Russo M,Faure H,Pellegrino G,Demongin C,Daynac M,Sharif A,Amosse J,Le Lay S,Denis R,Luquet S,Taouis M,Benomar Y,Ruat M

A-21271 was used in Immunohistochemistry to investigated the impact of genetic activation of Sonic hedgehog signaling on hypothalamic astrocytes and characterized its effects on energy metabolism.

Sat May 01 00:00:00 EDT 2021

High-fat diet impairs duodenal barrier function and elicits glia-dependent changes along the gut-brain axis that are required for anxiogenic and depressive-like behaviors.

Journal of neuroinflammation

Seguella L,Pesce M,Capuano R,Casano F,Pesce M,Corpetti C,Vincenzi M,Maftei D,Lattanzi R,Del Re A,Sarnelli G,Gulbransen BD,Esposito G

A-21271 was used in Immunohistochemistry to test the hypothesis that anxiogenic and depressive-like behaviors driven by consuming a HFD involve compromised duodenal barrier integrity and subsequent phenotypic changes to glia and neurons along the gut-brain axis.

Sun May 16 00:00:00 EDT 2021

Expression of Endogenous Angiotensin-Converting Enzyme 2 in Human Induced Pluripotent Stem Cell-Derived Retinal Organoids.

International journal of molecular sciences

Ahmad Mulyadi Lai HI,Chou SJ,Chien Y,Tsai PH,Chien CS,Hsu CC,Jheng YC,Wang ML,Chiou SH,Chou YB,Hwang DK,Lin TC,Chen SJ,Yang YP

A-21271 was used in Immunocytochemistry to investigate whether ACE2 expression plays a role in human retinal neurons during SARS-CoV-2 infection.

Thu Jan 28 00:00:00 EST 2021

Fmrp regulates oligodendrocyte lineage cell specification and differentiation.

Glia

Doll CA,Scott K,Appel B

A-21271 was used in Immunohistochemistry to suggest cell stage-specific requirements for Fmrp in the specification and differentiation of oligodendrocyte lineage cells.

Fri Oct 01 00:00:00 EDT 2021

Alpha-synuclein dynamics in induced pluripotent stem cell-derived dopaminergic neurons from a Parkinson's disease patient (PARK4) with SNCA triplication.

FEBS open bio

Fukusumi H,Togo K,Sumida M,Nakamori M,Obika S,Baba K,Shofuda T,Ito D,Okano H,Mochizuki H,Kanemura Y

A-21271 was used in Immunocytochemistry to investigate and understand the dynamics and regulation of alpha-synuclein levels in patients with Parkinson's disease.

Mon Feb 01 00:00:00 EST 2021

Fish primary embryonic pluripotent cells assemble into retinal tissue mirroring in vivo early eye development.

eLife

Zilova L,Weinhardt V,Tavhelidse T,Schlagheck C,Thumberger T,Wittbrodt J

A-21271 was used in Immunohistochemistry to derive organoids from rapidly developing teleosts to overcome limitations and address species-specific cellular organisation.

Mon Jul 12 00:00:00 EDT 2021

Quantitative analysis of enteric neurons containing choline acetyltransferase and nitric oxide synthase immunoreactivities in the submucosal and myenteric plexuses of the porcine colon.

Cell and tissue research

Mazzoni M,Caremoli F,Cabanillas L,de Los Santos J,Million M,Larauche M,Clavenzani P,De Giorgio R,Sternini C

A-21271 was used in Immunohistochemistry-immunofluorescence to establish that the ISP contains the highest number of HuC/D neurons/mm2, which were more abundant in AC vs. DC, followed by OSP and MP with similar density in AC and DC.

Mon Feb 01 00:00:00 EST 2021

Evidence for PKD2L1-positive neurons distant from the central canal in the ventromedial spinal cord and medulla of the adult mouse.

The European journal of neuroscience

Jurčić N,Michelle C,Trouslard J,Wanaverbecq N,Kastner A

A-21271 was used in Immunohistochemistry to describe a novel population of PKD2L1+ neurons distant from the CC but with properties similar to CSF-cNs that might serve to sense modification in the composition of either CSF or interstitial liquid, a function that will need to be confirmed.

Sun Aug 01 00:00:00 EDT 2021

Dystrophin in the Neonatal and Adult Rat Intestine.

Life (Basel, Switzerland)

Lionarons JM,Hoogland G,Slegers RJ,Steinbusch H,Claessen SMH,Vles JSH

A-21271 was used in Immunohistochemistry to study the distribution of dystrophin protein isoform 71 (Dp71) in the neonatal and adult rat intestine.

Fri Oct 29 00:00:00 EDT 2021

Intestinal microbiota shapes gut physiology and regulates enteric neurons and glia.

Microbiome

Vicentini FA,Keenan CM,Wallace LE,Woods C,Cavin JB,Flockton AR,Macklin WB,Belkind-Gerson J,Hirota SA,Sharkey KA

A-21271 was used in Immunohistochemistry-immunofluorescence to reveal new insights into the role of the gut microbiota that could lead to therapeutic developments for the treatment of enteric neuropathies.

Tue Oct 26 00:00:00 EDT 2021

NOX5 is expressed aberrantly but not a critical pathogenetic gene in Hirschsprung disease.

BMC pediatrics

Wang J,Xiao J,Meng X,Chu X,Zhuansun DD,Xiong B,Feng J

A-21271 was used in Immunocytochemistry to examine the function of NOX5 to verify its role in the development of the enteric nervous system (ENS).

Tue Mar 30 00:00:00 EDT 2021

HDL biodistribution and brain receptors in zebrafish, using HDLs as vectors for targeting endothelial cells and neural progenitors.

Scientific reports

Sulliman NC,Ghaddar B,Gence L,Patche J,Rastegar S,Meilhac O,Diotel N

A-21271 was used in Immunohistochemistry to suggest the use of HDLs as delivery vectors to target NSCs for drug delivery to boost their neurogenic activity.

Fri Mar 19 00:00:00 EDT 2021

Zebrafish harbor diverse intestinal macrophage populations including a subset intimately associated with enteric neural processes.

iScience

Graves CL,Chen A,Kwon V,Shiau CE

A-21271 was used in Immunohistochemistry to provide first insights into intestinal macrophages and their association with the enteric nervous system from development to adulthood in teleosts.

Fri Jun 25 00:00:00 EDT 2021

Diabetes Affects the Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP)-Like Immunoreactive Enteric Neurons in the Porcine Digestive Tract.

International journal of molecular sciences

Palus K,Bulc M,Całka J,Zielonka Ł,Nowicki M

A-21271 was used in Immunohistochemistry to elucidate, for the first time, the impact of prolonged hyperglycaemia conditions on a population of PACAP-like immunoreactive neurons in selected parts of the porcine gastrointestinal tract.

Thu May 27 00:00:00 EDT 2021

Structural Identification of the Pacemaker Cells and Expression of Hyperpolarization-Activated Cyclic Nucleotide-Gated (HCN) Channels in the Heart of the Wild Atlantic Cod, Gadus morhua (Linnaeus, 1758).

International journal of molecular sciences

Capillo G,Lauriano ER,Icardo JM,Siriyappagouder P,Kuciel M,Karapanagiotis S,Zaccone G,Fernandes JMO

A-21271 was used in Immunohistochemistry to show that cardiac pacemaking can be modulated by sympathetic and parasympathetic pathways, and the existence of intracardiac neurons projecting back to the central nervous system provide a plausible link between them.

Wed Jul 14 00:00:00 EDT 2021

Nitrergic and Substance P Immunoreactive Neurons in the Enteric Nervous System of the Bottlenose Dolphin (Tursiops truncatus) Intestine.

Animals : an open access journal from MDPI

Bombardi C,Rambaldi AM,Galiazzo G,Giancola F,Graïc JM,Salamanca G,Cozzi B,Chiocchetti R

A-21271 was used in Immunohistochemistry-immunofluorescence to describe the nitrergic and selected peptidergic systems in the myenteric plexus (MP) and submucosal plexus (SMP) of the intestine of the bottlenose dolphin (Tursiops truncatus).

Thu Apr 08 00:00:00 EDT 2021

Localization of the Serotonin Transporter in the Dog Intestine and Comparison to the Rat and Human Intestines.

Frontiers in veterinary science

Chiocchetti R,Galiazzo G,Giancola F,Tagliavia C,Bernardini C,Forni M,Pietra M

A-21271 was used in Immunohistochemistry to study the distribution of serotonin transporter (SERT) immunoreactivity in the dog intestine and to compare the findings with those obtained in the rat and human intestines.

Tue Jan 25 00:00:00 EST 2022

scRNA-Seq Reveals New Enteric Nervous System Roles for GDNF, NRTN, and TBX3.

Cellular and molecular gastroenterology and hepatology

Wright CM,Schneider S,Smith-Edwards KM,Mafra F,Leembruggen AJL,Gonzalez MV,Kothakapa DR,Anderson JB,Maguire BA,Gao T,Missall TA,Howard MJ,Bornstein JC,Davis BM,Heuckeroth RO

A-21271 was used in Immunohistochemistry to define gene expression in neuron subtypes required for bowl function, to facilitate development of novel therapeutic approaches to treat enteric neuropathies, and to learn more about enteric nervous system function.

Tue Mar 08 00:00:00 EST 2022

Hypothalamic Rax+ tanycytes contribute to tissue repair and tumorigenesis upon oncogene activation in mice.

Nature communications

Mu W,Li S,Xu J,Guo X,Wu H,Chen Z,Qiao L,Helfer G,Lu F,Liu C,Wu QF

A-21271 was used in Immunohistochemistry to offer insights into the properties of tanycytes, which may help to manipulate tanycyte biology for regulating hypothalamic function and investigate the pathogenesis of clinically relevant tumors.

Fri Apr 16 00:00:00 EDT 2021

Phenome-based approach identifies RIC1-linked Mendelian syndrome through zebrafish models, biobank associations and clinical studies.

Nature medicine

Unlu G,Qi X,Gamazon ER,Melville DB,Patel N,Rushing AR,Hashem M,Al-Faifi A,Chen R,Li B,Cox NJ,Alkuraya FS,Knapik EW

A-21271 was used in Immunohistochemistry to uncover a new mechanism for rare and common diseases resulting from collagen secretion deficits.

Wed Jan 01 00:00:00 EST 2020

Glial Cell-Derived Neurotrophic Factor Induces Enteric Neurogenesis and Improves Colon Structure and Function in Mouse Models of Hirschsprung Disease.

Gastroenterology

Soret R,Schneider S,Bernas G,Christophers B,Souchkova O,Charrier B,Righini-Grunder F,Aspirot A,Landry M,Kembel SW,Faure C,Heuckeroth RO,Pilon N

A-21271 was used in Immunocytochemistry to study whether administration of glial cell derived neurotrophic factor (GDNF) induces enteric nervous system regeneration in mouse models of HSCR.

Sun Nov 01 00:00:00 EDT 2020

SARS-CoV-2 Infects the Brain Choroid Plexus and Disrupts the Blood-CSF Barrier in Human Brain Organoids.

Cell stem cell

Pellegrini L,Albecka A,Mallery DL,Kellner MJ,Paul D,Carter AP,James LC,Lancaster MA

A-21271 was used in Immunohistochemistry-immunofluorescence to show that infection with SARS-CoV-2 damages the choroid plexus epithelium, leading to leakage across this important barrier that normally prevents entry of pathogens, immune cells, and cytokines into cerebrospinal fluid and the brain.

Thu Dec 03 00:00:00 EST 2020

Direct Readout of Neural Stem Cell Transgenesis with an Integration-Coupled Gene Expression Switch.

Neuron

Kumamoto T,Maurinot F,Barry-Martinet R,Vaslin C,Vandormael-Pournin S,Le M,Lerat M,Niculescu D,Cohen-Tannoudji M,Rebsam A,Loulier K,Nedelec S,Tozer S,Livet J

A-21271 was used in Immunohistochemistry to introduce an integration-coupled On genetic switch, iOn, which triggers gene expression upon incorporation into the host genome through transposition, thus enabling rapid and accurate identification of integration events following transfection with naked plasmids.

Wed Aug 19 00:00:00 EDT 2020

Ganglioneuromas are driven by activated AKT and can be therapeutically targeted with mTOR inhibitors.

The Journal of experimental medicine

Tao T,Shi H,Wang M,Perez-Atayde AR,London WB,Gutierrez A,Lemos B,Durbin AD,Look AT

A-21271 was used in Immunohistochemistry to propose a clinical trial of mTOR inhibitors as a means to shrink large ganglioneuromas before resection in order to reduce surgical morbidity.

Mon Oct 05 00:00:00 EDT 2020

Reprogramming Axial Level Identity to Rescue Neural-Crest-Related Congenital Heart Defects.

Developmental cell

Gandhi S,Ezin M,Bronner ME

A-21271 was used in Immunohistochemistry to reveal a transcriptional program sufficient to confer cardiac potential onto trunk neural crest cells, thus implicating new genes in cardiovascular birth defects.

Mon May 04 00:00:00 EDT 2020

Whole-genome analysis of noncoding genetic variations identifies multiscale regulatory element perturbations associated with Hirschsprung disease.

Genome research

Fu AX,Lui KN,Tang CS,Ng RK,Lai FP,Lau ST,Li Z,Garcia-Barcelo MM,Sham PC,Tam PK,Ngan ES,Yip KY

A-21271 was used in Western Blotting to show that a noncoding variant found only in the patients affects the binding of the gliogenesis regulator NFIA, with a corresponding up-regulation of multiple genes in the same topologically associating domain.

Sun Nov 01 00:00:00 EDT 2020

Microglia senescence occurs in both substantia nigra and ventral tegmental area.

Glia

Shaerzadeh F,Phan L,Miller D,Dacquel M,Hachmeister W,Hansen C,Bechtle A,Tu D,Martcheva M,Foster TC,Kumar A,Streit WJ,Khoshbouei H

A-21271 was used in Immunohistochemistry to test the hypothesis that aging-related changes in microglia and neurons occur in the vulnerable substantia nigra pars compacta but not the ventral tegmental area.

Sun Nov 01 00:00:00 EDT 2020

Tanycyte ablation in the arcuate nucleus and median eminence increases obesity susceptibility by increasing body fat content in male mice.

Glia

Yoo S,Cha D,Kim S,Jiang L,Cooke P,Adebesin M,Wolfe A,Riddle R,Aja S,Blackshaw S

A-21271 was used in Immunohistochemistry to demonstrate a role for tanycytes in regulating fat metabolism.

Thu Oct 01 00:00:00 EDT 2020

De novo enteric neurogenesis in post-embryonic zebrafish from Schwann cell precursors rather than resident cell types.

Development (Cambridge, England)

El-Nachef WN,Bronner ME

A-21271 was used in Immunohistochemistry to suggest that post-embryonic enteric neurogenesis occurs via gut-extrinsic Schwann cell precursors instead of classical glia in zebrafish.

Mon Jul 13 00:00:00 EDT 2020

Temporal control of Wnt signaling is required for habenular neuron diversity and brain asymmetry.

Development (Cambridge, England)

Guglielmi L,Bühler A,Moro E,Argenton F,Poggi L,Carl M

A-21271 was used in Immunohistochemistry to suggest a feedback mechanism whereby the tumor suppressor Wnt inhibitory factor Wif1 controls the Wnt dynamics in the environment of habenular precursor cells.

Mon Mar 16 00:00:00 EDT 2020

Targeted cell ablation in zebrafish using optogenetic transcriptional control.

Development (Cambridge, England)

Mruk K,Ciepla P,Piza PA,Alnaqib MA,Chen JK

A-21271 was used in Immunohistochemistry to demonstrate differences between the nitroreductase and M2 systems that influence their efficacies for specific applications.

Wed Jun 17 00:00:00 EDT 2020

Npas1+-Nkx2.1+ Neurons Are an Integral Part of the Cortico-pallido-cortical Loop.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Abecassis ZA,Berceau BL,Win PH,García D,Xenias HS,Cui Q,Pamukcu A,Cherian S,Hernández VM,Chon U,Lim BK,Kim Y,Justice NJ,Awatramani R,Hooks BM,Gerfen CR,Boca SM,Chan CS

A-21271 was used in Immunohistochemistry-immunofluorescence to establish the cellular and circuit substrates that can be important for motor function and dysfunction.

Wed Jan 22 00:00:00 EST 2020

Dysregulation of external globus pallidus-subthalamic nucleus network dynamics in parkinsonian mice during cortical slow-wave activity and activation.

The Journal of physiology

Kovaleski RF,Callahan JW,Chazalon M,Wokosin DL,Baufreton J,Bevan MD

A-21271 was used in Immunohistochemistry to suggest that in dopamine-depleted mice abnormally correlated and temporally offset PV GPe and STN neuron activity is generated in part by elevated striatopallidal transmission, while compensatory plasticity prevents STN hyperactivity and limits cortical entrainment.

Fri May 01 00:00:00 EDT 2020

Glia-Mediated Regenerative Response Following Acute Excitotoxic Damage in the Postnatal Squamate Retina.

Frontiers in cell and developmental biology

Eymann J,Di-Poï N

A-21271 was used in Immunohistochemistry (Paraffin) to establish and characterise a model of excitotoxic retinal damage in bearded dragon lizard (Pogona vitticeps).

Mon Sep 28 00:00:00 EDT 2020

Development of the intrinsic innervation of the small bowel mucosa and villi.

American journal of physiology. Gastrointestinal and liver physiology

Hao MM,Fung C,Boesmans W,Lowette K,Tack J,Vanden Berghe P

A-21271 was used in Immunohistochemistry to show that enteric neurites project into the lamina propria as early as E13.5 in the mouse, before development of the submucous plexus and before formation of intestinal villi.

Wed Jan 01 00:00:00 EST 2020

Gender-Related Differences of Tachykinin NK2 Receptor Expression and Activity in Human Colonic Smooth Muscle.

The Journal of pharmacology and experimental therapeutics

Drimousis S,Markus I,Murphy TV,Perera DS,Phan-Thien KC,Zhang L,Liu L

A-21271 was used in Immunohistochemistry to reveal gender-related variations in NK2 receptor activity, signaling transduction pathways, antagonist potency, and changes in expression with age.

Thu Oct 01 00:00:00 EDT 2020

Evaluation of Fluoro-Jade C Staining: Specificity and Application to Damaged Immature Neuronal Cells in the Normal and Injured Mouse Brain.

Neuroscience

Ikenari T,Kurata H,Satoh T,Hata Y,Mori T

A-21271 was used in Western Blot to validate the use of fluoro-Jade C as an appropriate stain for both normal and injured adult and embryonic mouse brains.

Wed Jan 15 00:00:00 EST 2020

Expression of Repressor Element 1 Silencing Transcription Factor (REST) in Serotonin Neurons in the Adult Male Nile Tilapia (Oreochromis niloticus).

Frontiers in neuroanatomy

Soga T,Nakajima S,Parhar IS

A-21271 was used in Immunocytochemistry to examine the expression of the REST gene in the brain (forebrain, midbrain, and hindbrain) of adult male Nile tilapia (Oreochromis niloticus) using rt-PCR.

Tue Mar 30 00:00:00 EDT 2021

HERC1 Ubiquitin Ligase Is Required for Hippocampal Learning and Memory.

Frontiers in neuroanatomy

Pérez-Villegas EM,Pérez-Rodríguez M,Negrete-Díaz JV,Ruiz R,Rosa JL,de Toledo GA,Rodríguez-Moreno A,Armengol JA

A-21271 was used in Immunohistochemistry to study the tbl hippocampus using behavioral tests, ex vivo electrophysiological recordings, immunohistochemistry, the Golgi-Cox method and transmission electron microscopy.

Fri Nov 10 00:00:00 EST 2023

Zika virus can directly infect and damage the auditory and vestibular components of the embryonic chicken inner ear.

Developmental dynamics : an official publication of the American Association of Anatomists

Thawani A,Sammudin NH,Reygaerts HS,Wozniak AN,Munnamalai V,Kuhn RJ,Fekete DM

A-21271 was used in Immunohistochemistry to present evidence of direct ZIKV infection of developing inner ear epithelium and shows previously unknown inner ear dysmorphogenesis phenotypes.

Wed Jul 01 00:00:00 EDT 2020

Neural cells and their progenitors in regenerating zebrafish spinal cord.

The International journal of developmental biology

Hui SP,Nag TC,Ghosh S

A-21271 was used in Immunohistochemistry to report ultrastructural and cell biological analyses of regeneration processes after spinal cord injury.

Thu Oct 14 00:00:00 EDT 2021

Effect of TNBS-induced colitis on enteric neuronal subpopulations in adult zebrafish.

European journal of histochemistry : EJH

Uyttebroek L,Pype C,Hubens G,Timmermans JP,Van Nassauw L

A-21271 was used in Immunohistochemistry-wholemount to investigate the effect of 2,4,6-trinitrobenzene sulphonic acid (TNBS)-induced colitis on changes in enteric neuronal subpopulations in adult zebrafish.

Fri Aug 28 00:00:00 EDT 2020

Colocalization pattern of cocaine- and amphetamine-regulated transcript peptide and parvalbumin immunoreactivity in the hippocampus proper of the chinchilla.

Polish journal of veterinary sciences

Szalak R,Matysek M,Kukula-Koch W,Rycerz K,Zacharko-Siembida A,Arciszewski MB

A-21271 was used in Immunohistochemistry to investigate the distribution and colocalization pattern of cocaine-and amphetamine-regulated transcript (CART) and one of the calcium binding- -proteins: parvalbumin (PV) in the chinchilla's hippocampus proper (HP).

Sun Mar 01 00:00:00 EST 2020

Expression of a Barhl1a reporter in subsets of retinal ganglion cells and commissural neurons of the developing zebrafish brain.

Scientific reports

Albadri S,Armant O,Aljand-Geschwill T,Del Bene F,Carl M,Strähle U,Poggi L

A-21271 was used in Immunohistochemistry to explore the spatio-temporal expression of a Barh1a reporter in retinal cells.

Mon Jun 01 00:00:00 EDT 2020

Analysis of enteric nervous system and intestinal epithelial barrier to predict complications in Hirschsprung's disease.

Scientific reports

Dariel A,Grynberg L,Auger M,Lefèvre C,Durand T,Aubert P,Le Berre-Scoul C,Venara A,Suply E,Leclair MD,de Vries P,Levard G,Parmentier B,Podevin G,Schmitt F,Couvrat V,Irtan S,Hervieux E,Villemagne T,Lardy H,Capito C,Muller C,Sarnacki S,Mosnier JF,Galmiche L,Derkinderen P,Boudin H,Brochard C,Neunlist M

A-21271 was used in Immunohistochemistry-immunofluorescence to show that modulating neuronal phenotype and enhancing IEB permeability may treat or prevent postoperative complications in HSCR.

Thu Dec 10 00:00:00 EST 2020

Fast Retrograde Access to Projection Neuron Circuits Underlying Vocal Learning in Songbirds.

Cell reports

Düring DN,Dittrich F,Rocha MD,Tachibana RO,Mori C,Okanoya K,Boehringer R,Ehret B,Grewe BF,Gerber S,Ma S,Rauch M,Paterna JC,Kasper R,Gahr M,Hahnloser RHR

A-21271 was used in Immunohistochemistry-immunofluorescence to present a viral tool that enables fast and efficient retrograde access to projection neuron populations.

Tue Nov 10 00:00:00 EST 2020

ARID1A loss in neuroblastoma promotes the adrenergic-to-mesenchymal transition by regulating enhancer-mediated gene expression.

Science advances

Shi H,Tao T,Abraham BJ,Durbin AD,Zimmerman MW,Kadoch C,Look AT

A-21271 was used in Immunohistochemistry-immunofluorescence to show that disruption of ARID1A homologs in a zebrafish model accelerates the onset and increases the penetrance of MYCN-driven neuroblastoma by increasing cell proliferation in the sympathoadrenal lineage.

Wed Jul 01 00:00:00 EDT 2020

Bsx Is Essential for Differentiation of Multiple Neuromodulatory Cell Populations in the Secondary Prosencephalon.

Frontiers in neuroscience

Schredelseker T,Veit F,Dorsky RI,Driever W

A-21271 was used in Immunohistochemistry to show that most bsx expression domains are dependent on Nkx2.1 and Nkx2.4 homeodomain transcription factors, while a subset depends on Otp.

Mon Sep 28 00:00:00 EDT 2020

Brain is an endocrine organ through secretion and nuclear transfer of parathymosin.

Life science alliance

Yu B,Tang Y,Cai D

A-21271 was used in Immunohistochemistry to report that parathymosin (PTMS) is secreted by hypothalamic stem/progenitor cells (htNSC) to inhibit senescence of recipient cells such as fibroblasts.

Tue Dec 01 00:00:00 EST 2020

P2X7 receptor antagonist recovers ileum myenteric neurons after experimental ulcerative colitis.

World journal of gastrointestinal pathophysiology

Souza RF,Evangelinellis MM,Mendes CE,Righetti M,Lourenço MCS,Castelucci P

A-21271 was used in Immunohistochemistry to report the effects of BBG in ileum enteric neurons immunoreactive (ir) following experimental ulcerative colitis in Rattus norvegicus albinus.

Sat Jun 20 00:00:00 EDT 2020

Vanishing white matter disease expression of truncated EIF2B5 activates induced stress response.

eLife

Keefe MD,Soderholm HE,Shih HY,Stevenson TJ,Glaittli KA,Bowles DM,Scholl E,Colby S,Merchant S,Hsu EW,Bonkowsky JL

A-21271 was used in Immunohistochemistry-immunofluorescence to develop zebrafish efi2b2 as a model of vanishing white matter disease(VMM), and the expression of human EIF2B in the zebrafish eif2b2 mutant rescues lethality and CNS apoptosis.

Thu Dec 10 00:00:00 EST 2020

Two C-terminal sequence variations determine differential neurotoxicity between human and mouse α-synuclein.

Molecular neurodegeneration

Landeck N,Strathearn KE,Ysselstein D,Buck K,Dutta S,Banerjee S,Lv Z,Hulleman JD,Hindupur J,Lin LK,Padalkar S,Stanciu LA,Lyubchenko YL,Kirik D,Rochet JC

A-21271 was used in Immunohistochemistry to study α-Synuclein mutations in humans, mice, and human-mouse chimeras and their respective associated pathophysiology.

Tue Sep 08 00:00:00 EDT 2020

Midkine-a functions as a universal regulator of proliferation during epimorphic regeneration in adult zebrafish.

PloS one

Ang NB,Saera-Vila A,Walsh C,Hitchcock PF,Kahana A,Thummel R,Nagashima M

A-21271 was used in Immunohistochemistry to evaluated regeneration of caudal fin, extraocular muscle and retinal neurons to investigate the function of Midkine-a during epimorphic regeneration, using a zebrafish Midkine-a loss of function mutant.

Thu Aug 13 00:00:00 EDT 2020

Generation of self-organized sensory ganglion organoids and retinal ganglion cells from fibroblasts.

Science advances

Xiao D,Deng Q,Guo Y,Huang X,Zou M,Zhong J,Rao P,Xu Z,Liu Y,Hu Y,Shen Y,Jin K,Xiang M

A-21271 was used in Immunohistochemistry to demonstrate the ability for ABI to reprogram induced RGCs (iRGCs) from fibroblasts.

Fri May 01 00:00:00 EDT 2020

Hedgehog Signaling Regulates Neurogenesis in the Larval and Adult Zebrafish Hypothalamus.

eNeuro

Male I,Ozacar AT,Fagan RR,Loring MD,Shen MC,Pace VA,Devine CA,Lawson GE,Lutservitz A,Karlstrom RO

A-21271 was used in Immunohistochemistry to suggest a mechanism for the control of hypothalamic growth and tissue renewal, as well as the plasticity in neuroendocrine cell populations that is now linked to hypothalamic function.

Fri Jun 18 00:00:00 EDT 2021

ACE2 Expression in the Cat and the Tiger Gastrointestinal Tracts.

Frontiers in veterinary science

Chiocchetti R,Galiazzo G,Fracassi F,Giancola F,Pietra M

A-21271 was used in immunohistochemistry (frozen) to investigate the expression of ACE2 in the gastrointestinal tract of domestic (cat) and wild (tiger) felines.

Mon Sep 28 00:00:00 EDT 2020

Defective development and microcirculation of intestine in Npr2 mutant mice.

Scientific reports

Sogawa-Fujiwara C,Hanagata A,Fujiwara Y,Ishida Y,Tomiyasu H,Kunieda T,Nakatomi H,Hori M

A-21271 was used in Immunofluorescence on wholemounted tissues to provide new insights into intractable gastrointestinal (GI) diseases, obesity, and NPR-B signaling.

Tue Sep 08 00:00:00 EDT 2020

Enteric Glia Modulate Macrophage Phenotype and Visceral Sensitivity following Inflammation.

Cell reports

Grubišić V,McClain JL,Fried DE,Grants I,Rajasekhar P,Csizmadia E,Ajijola OA,Watson RE,Poole DP,Robson SC,Christofi FL,Gulbransen BD

A-21271 was used in Immunohistochemistry to identify enteric glia as a critical link between gastrointestinal neural and immune systems that could be harnessed by therapies to ameliorate abdominal pain.

Tue Sep 08 00:00:00 EDT 2020

ADNP promotes neural differentiation by modulating Wnt/β-catenin signaling.

Nature communications

Sun X,Peng X,Cao Y,Zhou Y,Sun Y

A-21271 was used in Western Blotting to show that ADNP is required for neural induction and differentiation by enhancing Wnt signaling.

Fri Jun 12 00:00:00 EDT 2020

Characterization of gastrointestinal pathologies in the dystonia musculorum mouse model for hereditary sensory and autonomic neuropathy type VI.

Neurogastroenterology and motility

Lynch-Godrei A,De Repentigny Y,Yaworski RA,Gagnon S,Butcher J,Manoogian J,Stintzi A,Kothary R

A-21271 was used in Immunohistochemistry to show that parasympathetic GI input showed signs of neurodegeneration, while sympathetic did not.Dstdt-27J GI defects are not linked to ENS neurodegeneration, but are likely a result of an imbalance in autonomic control over the gut.

Wed Apr 01 00:00:00 EDT 2020

Increased (Pro)renin Receptor Expression in the Hypertensive Human Brain.

Frontiers in physiology

Mohsin M,Souza LAC,Aliabadi S,Worker CJ,Cooper SG,Afrin S,Murata Y,Xiong Z,Feng Earley Y

A-21271 was used in Immunohistochemistry-immunofluorescence to show the neural regulation of blood pressure, cardiovascular and metabolic function in humans is mediated by a (pro)renin receptor.

Thu Dec 24 00:00:00 EST 2020

Molecular Fingerprint and Developmental Regulation of the Tegmental GABAergic and Glutamatergic Neurons Derived from the Anterior Hindbrain.

Cell reports

Morello F,Borshagovski D,Survila M,Tikker L,Sadik-Ogli S,Kirjavainen A,Estartús N,Knaapi L,Lahti L,Törönen P,Mazutis L,Delogu A,Salminen M,Achim K,Partanen J

A-21271 was used in Immunohistochemistry to characterize the Tal1-dependent and independent neuronal precursors.

Tue Oct 13 00:00:00 EDT 2020

DSCAM regulates delamination of neurons in the developing midbrain.

Science advances

Arimura N,Okada M,Taya S,Dewa KI,Tsuzuki A,Uetake H,Miyashita S,Hashizume K,Shimaoka K,Egusa S,Nishioka T,Yanagawa Y,Yamakawa K,Inoue YU,Inoue T,Kaibuchi K,Hoshino M

A-21271 was used in Immunohistochemistry to show that Down syndrome cell adhesion molecule (DSCAM) controls neuronal delamination by local suppression of the RapGEF2-Rap1-N-cadherin cascade at the apical endfeet in the dorsal midbrain.

Tue Sep 01 00:00:00 EDT 2020

Pancreatic and intestinal endocrine cells in zebrafish share common transcriptomic signatures and regulatory programmes.

BMC biology

Lavergne A,Tarifeño-Saldivia E,Pirson J,Reuter AS,Flasse L,Manfroid I,Voz ML,Peers B

A-21271 was used in Immunohistochemistry-wholemount to investigate comprehensively the similarity of EECs and PECs by defining their transcriptomic landscape and comparing the regulatory programmes controlled by Pax6b, a key player in both EEC and PEC differentiations.

Mon Aug 31 00:00:00 EDT 2020

The EXTrauterine Environment for Neonatal Development Supports Normal Intestinal Maturation and Development.

Cellular and molecular gastroenterology and hepatology

Baumgarten HD,Wright CM,Rossidis AC,Lawrence KM,Kim AG,Mejaddam AY,McGovern PE,Orr MN,Coons BE,Butt Z,Li H,Hwang G,Radu A,Brown LJ,Rubenstein RC,Peranteau WH,Davey M,Heuckeroth RO,Flake AW

A-21271 was used in Immunohistochemistry (PFA fixed) to determine that the extra-uterine environment for neonatal development supports normal ileal epithelial and enteric nervous system maturation in pre-term lambs.

Tue Sep 07 00:00:00 EDT 2021

Gastrointestinal Neurons Expressing HCN4 Regulate Retrograde Peristalsis.

Cell reports

Fujii K,Nakajo K,Egashira Y,Yamamoto Y,Kitada K,Taniguchi K,Kawai M,Tomiyama H,Kawakami K,Uchiyama K,Ono F

A-21271 was used in Immunohistochemistry to reveal that a population of neurons expressing a hyperpolarization-activated nucleotide-gated channel HCN4 specifically regulates retrograde peristalsis.

Tue Mar 03 00:00:00 EST 2020

A Cellular-Resolution Atlas of the Larval Zebrafish Brain.

Neuron

Kunst M,Laurell E,Mokayes N,Kramer A,Kubo F,Fernandes AM,Förster D,Dal Maschio M,Baier H

A-21271 was used in Immunocytochemistry-immunoflourescence to image over 2,000 GFP-labeled neurons, resulting in an interactive cellular-resolution atlas of the zebrafish brain at 6 days post-fertilization.

Wed Jul 03 00:00:00 EDT 2019

Gene- and tissue-level interactions in normal gastrointestinal development and Hirschsprung disease.

Proceedings of the National Academy of Sciences of the United States of America

Chatterjee S,Nandakumar P,Auer DR,Gabriel SB,Chakravarti A

A-21271 was used in Immunohistochemistry-immunofluorescence to suggest that both cell autonomous and nonautonomous factors, and interactions between the different developing gut tissues, are important for normal ENS development and its disorders.

Thu Dec 26 00:00:00 EST 2019

Preclinical Assessment of Leptin Transport into the Cerebrospinal Fluid in Diet-Induced Obese Minipigs.

Obesity (Silver Spring, Md.)

Chmielewski A,Hubert T,Descamps A,Mazur D,Daoudi M,Ciofi P,Fontaine C,Caiazzo R,Pattou F,Prevot V,Pigeyre M

A-21271 was used in Immunohistochemistry-immunofluorescence to study the effect of high fat diet on endogenous leptin transport into the central nervous system and hypothalamic sensitivity.

Sat Jun 01 00:00:00 EDT 2019

Structurally defined signaling in neuro-glia units in the enteric nervous system.

Glia

Boesmans W,Hao MM,Fung C,Li Z,Van den Haute C,Tack J,Pachnis V,Vanden Berghe P

A-21271 was used in Immunohistochemistry-immunofluorescence to reveal the spatial and functional foundation of neuro-glia units as an operational cellular assembly in the enteric nervous system.

Sat Jun 01 00:00:00 EDT 2019

Nutrient restriction causes reversible G2 arrest in Xenopus neural progenitors.

Development (Cambridge, England)

McKeown CR,Cline HT

A-21271 was used in Immunohistochemistry to investigate how neural progenitors halt cell division in response to nutrient restriction and subsequently re-enter the cell cycle upon feeding.

Thu Oct 24 00:00:00 EDT 2019

Biallelic Mutations in TSC2 Lead to Abnormalities Associated with Cortical Tubers in Human iPSC-Derived Neurons.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Winden KD,Sundberg M,Yang C,Wafa SMA,Dwyer S,Chen PF,Buttermore ED,Sahin M

A-21271 was used in Immunocytochemistry to show that a single mutation in TSC2 is capable of causing mTORC1 hyperactivation and increased synchrony in human iPSC-derived neurons.

Wed Nov 20 00:00:00 EST 2019

Glucocorticoids Target Ependymal Glia and Inhibit Repair of the Injured Spinal Cord.

Frontiers in cell and developmental biology

Nelson CM,Lennon VA,Lee H,Krug RG,Kamalova A,Madigan NN,Clark KJ,Windebank AJ,Henley JR

A-21271 was used in Immunohistochemistry to examine the mechanism by which glucocorticoids inhibit neural repair following spinal cord injury.

Wed Sep 30 00:00:00 EDT 2020

Novel truncation mutations in MYRF cause autosomal dominant high hyperopia mapped to 11p12-q13.3.

Human genetics

Xiao X,Sun W,Ouyang J,Li S,Jia X,Tan Z,Hejtmancik JF,Zhang Q

A-21271 was used in Immunohistochemistry-immunofluorescence to provide useful clues for further understanding the functional role of the C-terminal region of this critical myelin regulatory factor, as well as the molecular pathogenesis of high hyperopia and its associated angle-closure glaucoma.

Tue Oct 01 00:00:00 EDT 2019

Maternal protein restriction induces gastrointestinal dysfunction and enteric nervous system remodeling in rat offspring.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Aubert P,Oleynikova E,Rizvi H,Ndjim M,Le Berre-Scoul C,Grohard PA,Chevalier J,Segain JP,Le Drean G,Neunlist M,Boudin H

A-21271 was used in Immunohistochemistry-immunofluorescence to show stressors later in life can induce enteric nervous system alterations and gastrointestinal dysfunction as a result of maternal protein restriction.

Tue Jan 01 00:00:00 EST 2019

Differential nickel-induced responses of olfactory sensory neuron populations in zebrafish.

Aquatic toxicology (Amsterdam, Netherlands)

Lazzari M,Bettini S,Milani L,Maurizii MG,Franceschini V

A-21271 was used in Immunohistochemistry to show that the results of this immunohistochemical study are not in line with those obtained by electro-olfactogram.

Tue Jan 01 00:00:00 EST 2019

CPSF1 mutations are associated with early-onset high myopia and involved in retinal ganglion cell axon projection.

Human molecular genetics

Ouyang J,Sun W,Xiao X,Li S,Jia X,Zhou L,Wang P,Zhang Q

A-21271 was used in Immunohistochemistry-immunofluorescence to determine the role of CPSF1 mutations in the development of retinal ganglion cell axon projection.

Sat Jun 15 00:00:00 EDT 2019

Mitotic activity, modulation of DNA processing, and purinergic signalling in the adult rat auditory brainstem following sensory deafferentation.

The European journal of neuroscience

Illing RB,Buschky H,Tadic A

A-21271 was used in Immunohistochemistry to investigate whether mitosis involves in a complex scenario of cellular network reorganization, caused by unilateral sensory deafferentation (USD) in the adult rat central auditory system.

Sun Dec 01 00:00:00 EST 2019

Endogenous amylin contributes to birth of microglial cells in arcuate nucleus of hypothalamus and area postrema during fetal development.

American journal of physiology. Regulatory, integrative and comparative physiology

Lutz TA,Le Foll C

A-21271 was used in Immunohistochemistry to study the role of amylin in the regulation of of cell birth in the arcuate nucleus and area postrema.

Sat Jun 01 00:00:00 EDT 2019

Epigenetic factors Dnmt1 and Uhrf1 coordinate intestinal development.

Developmental biology

Ganz J,Melancon E,Wilson C,Amores A,Batzel P,Strader M,Braasch I,Diba P,Kuhlman JA,Postlethwait JH,Eisen JS

A-21271 was used in Immunohistochemistry-immunofluorescence to find that functional loss of a DNA methylation machinery component, ubiquitin-like protein containing PHD and RING finger domain 1, leads to reduced numbers of ectoderm-derived enteric neurons and severe disruption of mesoderm-derived intestinal smooth muscle.

Fri Nov 15 00:00:00 EST 2019

Local heat-shock mediated multi-color labeling visualizing behaviors of enteric neural crest cells associated with division and neurogenesis in zebrafish gut.

Developmental dynamics : an official publication of the American Association of Anatomists

Kuwata M,Nikaido M,Hatta K

A-21271 was used in Immunohistochemistry to introduce a new method of visualizing individual enteric neural crest cells in the zebrafish gut, describe their behaviors associated with cell division, thus providing a foundation to study the mechanism of proliferation and neurogenesis in the enteric nervous system in vertebrates.

Sat Jun 01 00:00:00 EDT 2019

Comprehensive and cell-type-based characterization of the dorsal midbrain during development.

Genes to cells : devoted to molecular & cellular mechanisms

Arimura N,Dewa KI,Okada M,Yanagawa Y,Taya SI,Hoshino M

A-21271 was used in Immunofluorescence in immunohistochemistry on frozen tissues to characterise the ventricular zone, intermediate zone, and marginal zone based on various markers for proliferation and differentiation in embryonic dorsal midbrain.

Tue Jan 01 00:00:00 EST 2019

A genome-wide assessment of the ancestral neural crest gene regulatory network.

Nature communications

Hockman D,Chong-Morrison V,Green SA,Gavriouchkina D,Candido-Ferreira I,Ling ITC,Williams RM,Amemiya CT,Smith JJ,Bronner ME,Sauka-Spengler T

A-21271 was used in Immunohistochemistry-immunofluorescence to provide insight into the core gene regulatory network (GRN) elements conserved to the base of the vertebrates and expose others that are unique to lampreys.

Wed Oct 16 00:00:00 EDT 2019

Aberrant hiPSCs-Derived from Human Keratinocytes Differentiates into 3D Retinal Organoids that Acquire Mature Photoreceptors.

Cells

Shrestha R,Wen YT,Ding DC,Tsai RK

A-21271 was used in Immunocytochemistry-immunoflourescence to show that human induced pluripotent stem cells with abnormal chromosomal content are permissive to the generation of three-dimensional retinal organoids.

Wed Jan 09 00:00:00 EST 2019

Alzheimer's disease neuropathological change and loss of matrix/neuropil in patients with idiopathic Normal Pressure Hydrocephalus, a model of Alzheimer's disease.

Acta neuropathologica communications

Libard S,Alafuzoff I

A-21271 was used in Immunohistochemistry to assess unique brain tissue samples, obtained from living subjects with idiopathic Normal Pressure Hydrocephalus.

Wed May 29 00:00:00 EDT 2019

Looking through Brains with Fast Passive CLARITY: Zebrafish, Rodents, Non-human Primates and Humans.

Bio-protocol

Mortazavi F,Stankiewicz AJ,Zhdanova IV

A-21271 was used in Immunohistochemistry to provide our detailed protocol for PACT (Passive Clarity Technique) in brain tissue of diverse species, including human, non-human primate, rodents, and zebrafish.

Mon Aug 05 00:00:00 EDT 2019

Looking through Brains with Fast Passive CLARITY: Zebrafish, Rodents, Non-human Primates and Humans.

Bio-protocol

Mortazavi F,Stankiewicz AJ,Zhdanova IV

Mon Aug 05 00:00:00 EDT 2019

Looking through Brains with Fast Passive CLARITY: Zebrafish, Rodents, Non-human Primates and Humans.

Bio-protocol

Mortazavi F,Stankiewicz AJ,Zhdanova IV

Mon Aug 05 00:00:00 EDT 2019

Looking through Brains with Fast Passive CLARITY: Zebrafish, Rodents, Non-human Primates and Humans.

Bio-protocol

Mortazavi F,Stankiewicz AJ,Zhdanova IV

Mon Aug 05 00:00:00 EDT 2019

Oxidative Stress-Tolerant Stem Cells from Human Exfoliated Deciduous Teeth Decrease Hydrogen Peroxide-Induced Damage in Organotypic Brain Slice Cultures from Adult Mice.

International journal of molecular sciences

Xiao L,Saiki C,Okamura H

A-21271 was used in Immunohistochemistry-immunofluorescence to study the protective effects of oxidative stress tolerant stem cells harvested from human exfoliated deciduous teeth.

Mon Apr 15 00:00:00 EDT 2019

Tanycyte-Independent Control of Hypothalamic Leptin Signaling.

Frontiers in neuroscience

Yoo S,Cha D,Kim DW,Hoang TV,Blackshaw S

A-21271 was used in Immunohistochemistry to analyse the expression and function of the tanycytic leptin receptor in mice.

Wed Sep 30 00:00:00 EDT 2020

Methamphetamine regulation of activity and topology of ventral midbrain networks.

PloS one

Miller DR,Lebowitz JJ,Guenther DT,Refowich AJ,Hansen C,Maurer AP,Khoshbouei H

A-21271 was used in Immunocytochemistry to establish primary ventral midbrain networks culture as a viable model system that reveals specific changes in network activity, connectivity, and topology modulation by methamphetamine.

Mon Mar 23 00:00:00 EDT 2020

Molecular understanding of label-free second harmonic imaging of microtubules.

Nature communications

Van Steenbergen V,Boesmans W,Li Z,de Coene Y,Vints K,Baatsen P,Dewachter I,Ameloot M,Clays K,Vanden Berghe P

A-21271 was used in Immunocytochemistry-immunoflourescence to identifiy the determinants of the microtubule-dependent second harmonic signal.

Tue Aug 06 00:00:00 EDT 2019

Distribution and neuronal circuit of spexin 1/2 neurons in the zebrafish CNS.

Scientific reports

Kim E,Jeong I,Chung AY,Kim S,Kwon SH,Seong JY,Park HC

A-21271 was used in Immunohistochemistry to examine the distribution and neuronal circuit of spexin 1/2 neurons in the zebrafish central nervous system.

Fri Mar 22 00:00:00 EDT 2019

The Hippo Pathway Blocks Mammalian Retinal Müller Glial Cell Reprogramming.

Cell reports

Rueda EM,Hall BM,Hill MC,Swinton PG,Tong X,Martin JF,Poché RA

A-21271 was used in Immunohistochemistry-immunofluorescence to reveal that mammalian MGs may have latent regenerative capacity that can be stimulated by repressing Hippo signaling.

Tue May 07 00:00:00 EDT 2019

Microglia are an essential component of the neuroprotective scar that forms after spinal cord injury.

Nature communications

Bellver-Landete V,Bretheau F,Mailhot B,Vallières N,Lessard M,Janelle ME,Vernoux N,Tremblay MÈ,Fuehrmann T,Shoichet MS,Lacroix S

A-21271 was used in Immunohistochemistry-immunofluorescence to assess the response of microglia following spinal cord injury.

Thu Jan 31 00:00:00 EST 2019

Lineage specific transcription factors and epigenetic regulators mediate TGFβ-dependent enhancer activation.

Nucleic acids research

Fueyo R,Iacobucci S,Pappa S,Estarás C,Lois S,Vicioso-Mantis M,Navarro C,Cruz-Molina S,Reyes JC,Rada-Iglesias Á,de la Cruz X,Martínez-Balbás MA

A-21271 was used in Immunocytochemistry to examine the mechanisms underlying neural enhancer activation in response to TGFΒ signalling.

Fri Apr 20 00:00:00 EDT 2018

Intracellular Calcium Mobilization Is Required for Sonic Hedgehog Signaling.

Developmental cell

Klatt Shaw D,Gunther D,Jurynec MJ,Chagovetz AA,Ritchie E,Grunwald DJ

A-21271 was used in Immunohistochemistry to study the effect of intracellular calcium mobilisation on the level of Shh dependent cell types in the zebrafish embryo.

Mon May 21 00:00:00 EDT 2018

Temporal and Spatial Post-Transcriptional Regulation of Zebrafish tie1 mRNA by Long Noncoding RNA During Brain Vascular Assembly.

Arteriosclerosis, thrombosis, and vascular biology

Chowdhury TA,Koceja C,Eisa-Beygi S,Kleinstiver BP,Kumar SN,Lin CW,Li K,Prabhudesai S,Joung JK,Ramchandran R

A-21271 was used in Immunohistochemistry to identify a novel mode of temporal and spatial post-transcriptional regulation of tie1 mRNA.

Sun Jul 01 00:00:00 EDT 2018

Identification of Ca2+ signaling components in neural stem/progenitor cells during differentiation into neurons and glia in intact and dissociated zebrafish neurospheres.

Science China. Life sciences

Tse MK,Hung TS,Chan CM,Wong T,Dorothea M,Leclerc C,Moreau M,Miller AL,Webb SE

A-21271 was used in Immunocytochemistry to refine a protocol to generate proliferating and differentiating neurospheres from the entire brain of adult zebrafish.

Thu Nov 01 00:00:00 EDT 2018

Motor axon navigation relies on Fidgetin-like 1-driven microtubule plus end dynamics.

The Journal of cell biology

Fassier C,Fréal A,Gasmi L,Delphin C,Ten Martin D,De Gois S,Tambalo M,Bosc C,Mailly P,Revenu C,Peris L,Bolte S,Schneider-Maunoury S,Houart C,Nothias F,Larcher JC,Andrieux A,Hazan J

A-21271 was used in Immunohistochemistry-wholemount to identify the meiotic clade adenosine triphosphatase Fidgetin-like 1 as a key growth cone-enriched microtubule-interacting protein in motor circuit wiring and larval locomotion.

Mon May 07 00:00:00 EDT 2018

Notch signalling patterns retinal composition by regulating atoh7 during post-embryonic growth.

Development (Cambridge, England)

Pérez Saturnino A,Lust K,Wittbrodt J

A-21271 was used in Immunohistochemistry-immunofluorescence to elucidate the mechanism by which notch signalling patterns retinal composition.

Fri Nov 09 00:00:00 EST 2018

Bsx controls pineal complex development.

Development (Cambridge, England)

Schredelseker T,Driever W

A-21271 was used in Immunohistochemistry to identify the differentiation of multiple cell types in the zebrafish pineal complex is due to the brain-specific homeobox gene.

Mon Jul 09 00:00:00 EDT 2018

Epigenetic regulators Rbbp4 and Hdac1 are overexpressed in a zebrafish model of RB1 embryonal brain tumor, and are required for neural progenitor survival and proliferation.

Disease models & mechanisms

Schultz LE,Haltom JA,Almeida MP,Wierson WA,Solin SL,Weiss TJ,Helmer JA,Sandquist EJ,Shive HR,McGrail M

A-21271 was used in Immunohistochemistry to identify epigenetic regulators driving oncogenesis in a zebrafish retinoblastoma 1 somatic-targeting model of RB1 mutant embryonal brain tumours.

Fri Jun 15 00:00:00 EDT 2018

Establishment of a murine culture system for modeling the temporal progression of cranial and trunk neural crest cell differentiation.

Disease models & mechanisms

Replogle MR,Sreevidya VS,Lee VM,Laiosa MD,Svoboda KR,Udvadia AJ

A-21271 was used in Immunocytochemistry-immunoflourescence to optimise culture conditions for expansion of primary murine neural crest cells that give rise to both ectodermal and mesoectodermal derivatives, even after multiple passages.

Wed Dec 12 00:00:00 EST 2018

Etiology and functional validation of gastrointestinal motility dysfunction in a zebrafish model of CHARGE syndrome.

The FEBS journal

Cloney K,Steele SL,Stoyek MR,Croll RP,Smith FM,Prykhozhij SV,Brown MM,Midgen C,Blake K,Berman JN

A-21271 was used in Immunohistochemistry-wholemount to highlight the opportunity of the zebrafish to serve as a preclinical model for studying compounds that may improve GI motility in individuals with CHARGE syndrome.

Fri Jun 01 00:00:00 EDT 2018

Anatomical and Functional Changes to the Colonic Neuromuscular Compartment after Experimental Spinal Cord Injury.

Journal of neurotrauma

White AR,Holmes GM

A-21271 was used in Immunohistochemistry to study the colonic alterations that occur after spinal cord injury.

Tue May 01 00:00:00 EDT 2018

Hypoxia activates a neuropeptidergic pathway from the paraventricular nucleus of the hypothalamus to the nucleus tractus solitarii.

American journal of physiology. Regulatory, integrative and comparative physiology

Ruyle BC,Klutho PJ,Baines CP,Heesch CM,Hasser EM

A-21271 was used in Immunohistochemistry to study paraventricular nucleus corticotropin-releasing hormone projections to the nucleus tractus solitarii, as contributors to chemoreflex cardiorespiratory responses.

Sat Dec 01 00:00:00 EST 2018

Cellular fate decisions in the developing female anteroventral periventricular nucleus are regulated by canonical Notch signaling.

Developmental biology

Biehl MJ,Kaylan KB,Thompson RJ,Gonzalez RV,Weis KE,Underhill GH,Raetzman LT

A-21271 was used in Immunohistochemistry (Frozen) to study how Notch signalling effects the development of the anteroventral periventricular nucleus.

Mon Oct 01 00:00:00 EDT 2018

Multiple zebrafish atoh1 genes specify a diversity of neuronal types in the zebrafish cerebellum.

Developmental biology

Kidwell CU,Su CY,Hibi M,Moens CB

A-21271 was used in Immunohistochemistry-wholemount to report that zebrafish atoh1c-expressing cells are organized in two distinct domains that are separated both by space and developmental time.

Fri Jun 01 00:00:00 EDT 2018

Striking parallels between carotid body glomus cell and adrenal chromaffin cell development.

Developmental biology

Hockman D,Adameyko I,Kaucka M,Barraud P,Otani T,Hunt A,Hartwig AC,Sock E,Waithe D,Franck MCM,Ernfors P,Ehinger S,Howard MJ,Brown N,Reese J,Baker CVH

A-21271 was used in Immunohistochemistry to resolve a paradox for the emigre hypothesis in the chicken - where the nearest ganglion to the carotid body is the nodose, in which the satellite glia are neural crest-derived, but the neurons are almost entirely placode-derived - by fate-mapping putative nodose neuronal emiges to the neural crest.

Sat Dec 01 00:00:00 EST 2018

A critical period for the trophic actions of leptin on AgRP neurons in the arcuate nucleus of the hypothalamus.

The Journal of comparative neurology

Kamitakahara A,Bouyer K,Wang CH,Simerly R

A-21271 was used in Immunohistochemistry on frozen tissues to study the critical period of leptin-stimulated Agouti-Related peptide neuron growth in the arcuate nucleus of the hypothalamus.

Mon Jan 01 00:00:00 EST 2018

Calcineurin B1 Deficiency in Glial Cells Induces Mucosal Degeneration and Inflammation in Mouse Small Intestine.

Biological & pharmaceutical bulletin

Fujita M,Yagi T,Okura U,Tanaka J,Hirashima N,Tanaka M

A-21271 was used in Immunohistochemistry to show the calcineurin B1 deficiency in glial cells impairs the small intestine and leads to malnutrition and eventual death in mice, suggesting that calcineurin plays a novel and important role in enteric glial cells.

Mon Sep 24 00:00:00 EDT 2018

Re-evaluation of neuronal P2X7 expression using novel mouse models and a P2X7-specific nanobody.

eLife

Kaczmarek-Hajek K,Zhang J,Kopp R,Grosche A,Rissiek B,Saul A,Bruzzone S,Engel T,Jooss T,Krautloher A,Schuster S,Magnus T,Stadelmann C,Sirko S,Koch-Nolte F,Eulenburg V,Nicke A

A-21271 was used in Immunohistochemistry-immunofluorescence to study neuronal P2X7 expression using novel mouse models and a P2X7-specific nanobody.

Fri Aug 03 00:00:00 EDT 2018

Activating the regenerative potential of Müller glia cells in a regeneration-deficient retina.

eLife

Lust K,Wittbrodt J

A-21271 was used in Immunohistochemistry-immunofluorescence to study the differential response in retinal regeneration between medaka and zebrafish.

Mon Jan 29 00:00:00 EST 2018

Disrupted alternative splicing for genes implicated in splicing and ciliogenesis causes PRPF31 retinitis pigmentosa.

Nature communications

Buskin A,Zhu L,Chichagova V,Basu B,Mozaffari-Jovin S,Dolan D,Droop A,Collin J,Bronstein R,Mehrotra S,Farkas M,Hilgen G,White K,Pan KT,Treumann A,Hallam D,Bialas K,Chung G,Mellough C,Ding Y,Krasnogor N,Przyborski S,Zwolinski S,Al-Aama J,Alharthi S,Xu Y,Wheway G,Szymanska K,McKibbin M,Inglehearn CF,Elliott DJ,Lindsay S,Ali RR,Steel DH,Armstrong L,Sernagor E,Urlaub H,Pierce E,Lührmann R,Grellscheid SN,Johnson CA,Lako M

A-21271 was used in Immunocytochemistry to study the occurrence of disrupted alternative splicing for specific splicing programmes.

Fri Oct 12 00:00:00 EDT 2018

Reduction of the ATPase inhibitory factor 1 (IF1) leads to visual impairment in vertebrates.

Cell death & disease

Martín-Jiménez R,Faccenda D,Allen E,Reichel HB,Arcos L,Ferraina C,Strobbe D,Russell C,Campanella M

A-21271 was used in Immunohistochemistry-immunofluorescence to examine the role of ATPase inhibitor factor 1 in brain development.

Mon Jun 04 00:00:00 EDT 2018

Mitochondrial enzyme GLUD2 plays a critical role in glioblastoma progression.

EBioMedicine

Franceschi S,Corsinovi D,Lessi F,Tantillo E,Aretini P,Menicagli M,Scopelliti C,Civita P,Pasqualetti F,Naccarato AG,Ori M,Mazzanti CM

A-21271 was used in Immunohistochemistry to investigate GLUD2 relevance in cancer cell behaviour by GLUD2 overexpression and silencing in two different human glioblastoma cell lines.

Thu Nov 01 00:00:00 EDT 2018

Aging-dependent decrease in the numbers of enteric neurons, interstitial cells of Cajal and expression of connexin43 in various regions of gastrointestinal tract.

Aging

Sun T,Li D,Hu S,Huang L,Sun H,Yang S,Wu B,Ji F,Zhou D

A-21271 was used in Western Blotting to study ageing-associated differences between different organs and the exact time to start degenerating.

Tue Dec 11 00:00:00 EST 2018

Analysis of human ES cell differentiation establishes that the dominant isoforms of the lncRNAs RMST and FIRRE are circular.

BMC genomics

Izuogu OG,Alhasan AA,Mellough C,Collin J,Gallon R,Hyslop J,Mastrorosa FK,Ehrmann I,Lako M,Elliott DJ,Santibanez-Koref M,Jackson MS

A-21271 was used in Immunocytochemistry to analyse lineage specificities of circular RNA in embryonic stem cells.

Fri Apr 20 00:00:00 EDT 2018

A hPSC-based platform to discover gene-environment interactions that impact human β-cell and dopamine neuron survival.

Nature communications

Zhou T,Kim TW,Chong CN,Tan L,Amin S,Sadat Badieyan Z,Mukherjee S,Ghazizadeh Z,Zeng H,Guo M,Crespo M,Zhang T,Kenyon R,Robinson CL,Apostolou E,Wang H,Xiang JZ,Evans T,Studer L,Chen S

A-21271 was used in Immunocytochemistry to identify an environmental chemical that contributes to human Β-cell and dopamine neuron loss, and validate a novel human pluripotent stem cells-based platform for determining gene-environment interactions.

Fri Nov 16 00:00:00 EST 2018

Calbindin D28k-Immunoreactivity in Human Enteric Neurons.

International journal of molecular sciences

Zetzmann K,Strehl J,Geppert C,Kuerten S,Jabari S,Brehmer A

A-21271 was used in Immunohistochemistry to discover that several neuron populations display occasional calbindin reactivity, making it unsuitable as a exclusive marker for type III neurons.

Mon Jan 08 00:00:00 EST 2018

Regeneration of diaphragm with bio-3D cellular patch.

Biomaterials

Zhang XY,Yanagi Y,Sheng Z,Nagata K,Nakayama K,Taguchi T

A-21271 was used in Immunohistochemistry-paraffin to study a novel bio-3D printer method to generate large scaffold-free tissue patches composed of human cells.

Fri Jun 01 00:00:00 EDT 2018

Quantification and neurochemical coding of the myenteric plexus in humans: No regional variation between the distal colon and rectum.

Neurogastroenterology and motility

Ng KS,Montes-Adrian NA,Mahns DA,Gladman MA

A-21271 was used in Immunohistochemistry to used paired wholemounts to accurately quantify and neurochemically code the hindgut myenteric plexus, comparing human distal colon and rectum.Paired human descending colonic/rectal specimens were procured from 15 patients undergoing anterior resection.

Thu Mar 01 00:00:00 EST 2018

Cell-specific pallidal intervention induces long-lasting motor recovery in dopamine-depleted mice.

Nature neuroscience

Mastro KJ,Zitelli KT,Willard AM,Leblanc KH,Kravitz AV,Gittis AH

A-21271 was used in Immunohistochemistry to establish the utility of cell-specific interventions in the globus pallidus to target functionally distinct pathways inducing long-lasting recovery of movement.

Thu Jun 01 00:00:00 EDT 2017

Molecular Anatomy of the Developing Human Retina.

Developmental cell

Hoshino A,Ratnapriya R,Brooks MJ,Chaitankar V,Wilken MS,Zhang C,Starostik MR,Gieser L,La Torre A,Nishio M,Bates O,Walton A,Bermingham-McDonogh O,Glass IA,Wong ROL,Swaroop A,Reh TA

A-21271 was used in Immunohistochemistry to define three key epochs in the transcriptome dynamics of human retina from foetal day 52 to 136.

Mon Dec 18 00:00:00 EST 2017

The Immune Signaling Adaptor LAT Contributes to the Neuroanatomical Phenotype of 16p11.2 BP2-BP3 CNVs.

American journal of human genetics

Loviglio MN,Arbogast T,Jønch AE,Collins SC,Popadin K,Bonnet CS,Giannuzzi G,Maillard AM,Jacquemont S,Yalcin B,Katsanis N,Golzio C,Reymond A

A-21271 was used in Immunohistochemistry to assess how the immune signalling adaptor, LAT, contributes to 16p11.2 220 kb BP2-BP3 copy-number variant-associated neurodevelopmental phenotypes.

Thu Oct 05 00:00:00 EDT 2017

Lef1-dependent hypothalamic neurogenesis inhibits anxiety.

PLoS biology

Xie Y,Kaufmann D,Moulton MJ,Panahi S,Gaynes JA,Watters HN,Zhou D,Xue HH,Fung CM,Levine EM,Letsou A,Brennan KC,Dorsky RI

A-21271 was used in Immunohistochemistry to demonstrate that the Wnt/Β-catenin effector Lef1 is required for the differentiation of anxiolytic hypothalamic neurons in zebrafish and mice.

Tue Aug 01 00:00:00 EDT 2017

The pre-rRNA processing factor DEF is rate limiting for the pathogenesis of MYCN-driven neuroblastoma.

Oncogene

Tao T,Sondalle SB,Shi H,Zhu S,Perez-Atayde AR,Peng J,Baserga SJ,Look AT

A-21271 was used in Immunohistochemistry to indicate that digestive organ expansion factor and other components of the small ribosomal subunit processome provide a novel site of vulnerability in neuroblastoma cells.

Thu Jul 06 00:00:00 EDT 2017

Dusp16 Deficiency Causes Congenital Obstructive Hydrocephalus and Brain Overgrowth by Expansion of the Neural Progenitor Pool.

Frontiers in molecular neuroscience

Zega K,Jovanovic VM,Vitic Z,Niedzielska M,Knaapi L,Jukic MM,Partanen J,Friedel RH,Lang R,Brodski C

A-21271 was used in Immunohistochemistry on paraffin embedded tissues to study the consequences of genetically inactivating dual-specificity phosphatase 16 on the development of congenital obstructive hydrocephalus and brain overgrowth.

Tue Sep 29 00:00:00 EDT 2020

A novel brain tumour model in zebrafish reveals the role of YAP activation in MAPK- and PI3K-induced malignant growth.

Disease models & mechanisms

Mayrhofer M,Gourain V,Reischl M,Affaticati P,Jenett A,Joly JS,Benelli M,Demichelis F,Poliani PL,Sieger D,Mione M

A21271 was used in immunohistochemistry - paraffin section to propose that neurodevelopmental disorders and brain tumors may arise from changes in oncogenes

Sun Jan 01 00:00:00 EST 2017

Age-Dependent Alpha-Synuclein Accumulation and Phosphorylation in the Enteric Nervous System in a Transgenic Mouse Model of Parkinson's Disease.

Neuroscience bulletin

Zhong CB,Chen QQ,Haikal C,Li W,Svanbergsson A,Diepenbroek M,Li JY

A-21271 was used in Immunohistochemistry-immunofluorescence to characterise the age-dependent morphological alterations and aggregation of α-synuclein in the enteric nervous system in an α-synuclein transgenic mouse model.

Sun Oct 01 00:00:00 EDT 2017

Octodon degus, a new model to study the agonist and plexus-induced response in the urinary bladder.

Journal of physiology and biochemistry

Martin-Cano FE,Caso-Agundez M,Camello-Almaraz C,Santos FJ,Espin MT,Madrid JA,Diez-Perez A,Camello PJ,Pozo MJ

A21271 was used in immunohistochemistry - paraffin section to study the contractility of the detrusor muscle and the morphology and code of the vesical plexus from Octodon degus

Wed Feb 01 00:00:00 EST 2017

Sox2 regulates Müller glia reprogramming and proliferation in the regenerating zebrafish retina via Lin28 and Ascl1a.

Experimental eye research

Gorsuch RA,Lahne M,Yarka CE,Petravick ME,Li J,Hyde DR

A-21271 was used in Immunohistochemistry-immunofluorescence to examine if Sox2 is involved in the early reprogramming-like events that Muller glia undergo as they upregulate many pluripotency- and neural stem cell-associated genes required for proliferation in light-damaged adult zebrafish retinas.

Tue Aug 01 00:00:00 EDT 2017

Cellular responses to recurrent pentylenetetrazole-induced seizures in the adult zebrafish brain.

Neuroscience

Duy PQ,Berberoglu MA,Beattie CE,Hall CW

A-21271 was used in Immunohistochemistry to investigate the cellular responses to recurrent pentylenetetrazole seizures in the adult zebrafish brain.

Thu May 04 00:00:00 EDT 2017

CRISPR/Cas9-Mediated Zebrafish Knock-in as a Novel Strategy to Study Midbrain-Hindbrain Boundary Development.

Frontiers in neuroanatomy

Kesavan G,Chekuru A,Machate A,Brand M

A-21271 was used in Immunohistochemistry to generate four CRISPR/Cas9-based knock-in fluorescent reporter lines for otx2 and pax2a, which are involved in midbrain-hindbrain boundary development.

Thu Oct 01 00:00:00 EDT 2020

Comparative analysis of monoaminergic cerebrospinal fluid-contacting cells in Osteichthyes (bony vertebrates).

The Journal of comparative neurology

Xavier AL,Fontaine R,Bloch S,Affaticati P,Jenett A,Demarque M,Vernier P,Yamamoto K

A-21271 was used in Immunohistochemistry-immunofluorescence to compare the organisation of cerebrospinal fluid-contacting cells in chicken, Xenopus, and zebrafish.

Thu Jun 15 00:00:00 EDT 2017

Comparative analysis of monoaminergic cerebrospinal fluid-contacting cells in Osteichthyes (bony vertebrates).

The Journal of comparative neurology

Xavier AL,Fontaine R,Bloch S,Affaticati P,Jenett A,Demarque M,Vernier P,Yamamoto K

A-21271 was used in Immunohistochemistry-immunofluorescence to compare the organisation of cerebrospinal fluid-contacting cells in chicken, Xenopus, and zebrafish.

Thu Jun 15 00:00:00 EDT 2017

Comparative analysis of monoaminergic cerebrospinal fluid-contacting cells in Osteichthyes (bony vertebrates).

The Journal of comparative neurology

Xavier AL,Fontaine R,Bloch S,Affaticati P,Jenett A,Demarque M,Vernier P,Yamamoto K

A-21271 was used in Immunohistochemistry-immunofluorescence to compare the organisation of cerebrospinal fluid-contacting cells in chicken, Xenopus, and zebrafish.

Thu Jun 15 00:00:00 EDT 2017

A Developmental Study of the Cerebellar Nucleus in the Catshark, a Basal Gnathostome.

Brain, behavior and evolution

Pose-Méndez S,Rodríguez-Moldes I,Candal E,Mazan S,Anadón R

A-21271 was used in Immunohistochemistry to gain insight into the evolution and development of the cerebellar nucleus.

Wed Jul 19 00:00:00 EDT 2017

Distribution and immunohistochemical characteristics of cocaine- and amphetamineregulated transcript-positive nerve elements in the pelvic ganglia of the female pig.

Polish journal of veterinary sciences

Zacharko-Siembida A,Matysek M,Szalak R,Radlińska A,Obszańska K,Arciszewski MB

A-21271 was used in Immunofluorescence in immunohistochemistry on frozen tissues to investigate the distribution patterns of cocaine- and amphetamine-regulated transcript-like immunoreactivity in the pelvic plexus of the female pig.

Tue Mar 28 00:00:00 EDT 2017

Arundic Acid Prevents Developmental Upregulation of S100B Expression and Inhibits Enteric Glial Development.

Frontiers in cellular neuroscience

Hao MM,Capoccia E,Cirillo C,Boesmans W,Vanden Berghe P

A21271 was used in immunohistochemistry to evaluate the influences of S100B synthesis in enteric nervous system development

Tue Sep 29 00:00:00 EDT 2020

Enteric innervation combined with proteomics for the evaluation of the effects of chronic fluoride exposure on the duodenum of rats.

Scientific reports

Melo CGS,Perles JVCM,Zanoni JN,Souza SRG,Santos EX,Leite AL,Heubel AD,E Souza CO,Souza JG,Buzalaf MAR

A-21271 was used in Immunohistochemistry-immunofluorescence to evaluate the effects of chronic fluoride exposure on the duodenum in rats.

Fri Apr 21 00:00:00 EDT 2017

Potent and Selective BACE-1 Peptide Inhibitors Lower Brain Aβ Levels Mediated by Brain Shuttle Transport.

EBioMedicine

Ruderisch N,Schlatter D,Kuglstatter A,Guba W,Huber S,Cusulin C,Benz J,Rufer AC,Hoernschemeyer J,Schweitzer C,Bülau T,Gärtner A,Hoffmann E,Niewoehner J,Patsch C,Baumann K,Loetscher H,Kitas E,Freskgård PO

A-21271 was used in Immunofluorescence to demonstrate that the Brain Shuttle is essential for BACE1 peptide inhibitors to be efficacious in the brain and active-exosite design of BACE1 peptide inhibitors may be of therapeutic relevance.

Sun Oct 01 00:00:00 EDT 2017

In Vivo Analysis of the Neurovascular Niche in the Developing Xenopus Brain.

eNeuro

Lau M,Li J,Cline HT

A-21271 was used in Immunohistochemistry to characterise the neurovascular niche during development in the Xenopus laevis tadpole brain.

Thu May 03 00:00:00 EDT 2018

MicroRNA miR-29 controls a compensatory response to limit neuronal iron accumulation during adult life and aging.

BMC biology

Ripa R,Dolfi L,Terrigno M,Pandolfini L,Savino A,Arcucci V,Groth M,Terzibasi Tozzini E,Baumgart M,Cellerino A

A21271 was used in immunohistochemistry - frozen section to analyze the role of the microRNA miR-29 in limiting neuronal iron accumulation

Mon Feb 13 00:00:00 EST 2017

Neuron loss and degeneration in the progression of TDP-43 in frontotemporal lobar degeneration.

Acta neuropathologica communications

Yousef A,Robinson JL,Irwin DJ,Byrne MD,Kwong LK,Lee EB,Xu Y,Xie SX,Rennert L,Suh E,Van Deerlin VM,Grossman M,Lee VM,Trojanowski JQ

A-21271 was used in Immunohistochemistry to explore if cortical neurons decreased with increasing TDP-43 inclusion pathology in the postmortem brains of FTLD-TDP patients.

Wed Sep 06 00:00:00 EDT 2017

Neurogenic Radial Glia-like Cells in Meninges Migrate and Differentiate into Functionally Integrated Neurons in the Neonatal Cortex.

Cell stem cell

Bifari F,Decimo I,Pino A,Llorens-Bobadilla E,Zhao S,Lange C,Panuccio G,Boeckx B,Thienpont B,Vinckier S,Wyns S,Bouché A,Lambrechts D,Giugliano M,Dewerchin M,Martin-Villalba A,Carmeliet P

A-21271 was used in Immunohistochemistry to identify radial glia-like cells present in the meninges that migrate and differentiate into functional neurons in the neonatal cerebral cortex.

Thu Mar 02 00:00:00 EST 2017

A subset of ipRGCs regulates both maturation of the circadian clock and segregation of retinogeniculate projections in mice.

eLife

Chew KS,Renna JM,McNeill DS,Fernandez DC,Keenan WT,Thomsen MB,Ecker JL,Loevinsohn GS,VanDunk C,Vicarel DC,Tufford A,Weng S,Gray PA,Cayouette M,Herzog ED,Zhao H,Berson DM,Hattar S

A-21271 was used in Immunohistochemistry on frozen tissues to identify a shared developmental mechanism for the maturation of the circadian clock and refinement of eye-specific segregation.

Thu Jun 15 00:00:00 EDT 2017

Localization of the 5-hydroxytryptamine 4 receptor in equine enteric neurons and extrinsic sensory fibers.

Neurogastroenterology and motility

Giancola F,Rambaldi AM,Bianco F,Iusco S,Romagnoli N,Tagliavia C,Bombardi C,Clavenzani P,De Giorgio R,Chiocchetti R

A-21271 was used in Immunohistochemistry-immunofluorescence to evaluated the distribution of 5-HT4 in the horse intestine and in foals with enteric aganglionosis, reminiscent of human Hirschsprung's disease.

Sat Jul 01 00:00:00 EDT 2017

Distinct roles of neuroepithelial-like and radial glia-like progenitor cells in cerebellar regeneration.

Development (Cambridge, England)

Kaslin J,Kroehne V,Ganz J,Hans S,Brand M

A-21271 was used in Immunohistochemistry to find that neuroepithelial cells are the predominant stem cell type supporting cerebellar regeneration after injury.

Sat Apr 15 00:00:00 EDT 2017

Food restriction reduces neurogenesis in the avian hippocampal formation.

PloS one

Robertson BA,Rathbone L,Cirillo G,D'Eath RB,Bateson M,Boswell T,Wilson PW,Dunn IC,Smulders TV

A-21271 was used in Immunohistochemistry to investigate the sensitivity of the avian post-natal and adult neurogenesis to chronic stressors.

Fri Dec 29 00:00:00 EST 2017

Effects of exogenous glucagon-like peptide-2 and distal bowel resection on intestinal and systemic adaptive responses in rats.

PloS one

Lai SW,de Heuvel E,Wallace LE,Hartmann B,Holst JJ,Brindle ME,Chelikani PK,Sigalet DL

A-21271 was used in Immunohistochemistry to determine the effects of exogenous glucagon-like peptide-2, with or without massive distal bowel resection, on adaptation of jejunal mucosa, enteric neurons, gut hormones and tissue reserves in rats.

Thu Sep 21 00:00:00 EDT 2017

The effects of aging on Amyloid-β42-induced neurodegeneration and regeneration in adult zebrafish brain.

Neurogenesis (Austin, Tex.)

Bhattarai P,Thomas AK,Zhang Y,Kizil C

A-21271 was used in Immunohistochemistry to compare old and young zebrafish to address the effects of ageing on regenerative ability following Amyloid-Β42 deposition.

Fri Mar 18 00:00:00 EDT 2022

Targeted Pth4-expressing cell ablation impairs skeletal mineralization in zebrafish.

PloS one

Suarez-Bregua P,Saxena A,Bronner ME,Rotllant J

A-21271 was used in Immunohistochemistry to investigate the role of pth4 during skeletal development in zebrafish.

Mon Oct 30 00:00:00 EDT 2017

Striatal adenosine A2A receptor neurons control active-period sleep via parvalbumin neurons in external globus pallidus.

eLife

Yuan XS,Wang L,Dong H,Qu WM,Yang SR,Cherasse Y,Lazarus M,Schiffmann SN,d'Exaerde AK,Li RX,Huang ZL

A-21271 was used in Immunohistochemistry-floating tissue to reveal a prominent contribution of striatal A2Areceptors neuron/external globus pallidu parvalbumin neuron circuit in sleep control.

Thu Oct 12 00:00:00 EDT 2017

North Carolina Macular Dystrophy Is Caused by Dysregulation of the Retinal Transcription Factor PRDM13.

Ophthalmology

Small KW,DeLuca AP,Whitmore SS,Rosenberg T,Silva-Garcia R,Udar N,Puech B,Garcia CA,Rice TA,Fishman GA,Héon E,Folk JC,Streb LM,Haas CM,Wiley LA,Scheetz TE,Fingert JH,Mullins RF,Tucker BA,Stone EM

A-21271 was used in immunocytochemistry to identify mutations that contribute North Carolina macular dystrophy

Fri Jan 01 00:00:00 EST 2016

Microglial Acid Sensing Regulates Carbon Dioxide-Evoked Fear.

Biological psychiatry

Vollmer LL,Ghosal S,McGuire JL,Ahlbrand RL,Li KY,Santin JM,Ratliff-Rang CA,Patrone LG,Rush J,Lewkowich IP,Herman JP,Putnam RW,Sah R

A-21271 was used in Immunohistochemistry-immunofluorescence to identify TDAG8-dependent microglial acid sensing as a unique chemosensor for detecting and translating hypercapnia to fear-associated behavioral and physiological responses.

Sat Oct 01 00:00:00 EDT 2016

PPARγ Is Activated during Congenital Cytomegalovirus Infection and Inhibits Neuronogenesis from Human Neural Stem Cells.

PLoS pathogens

Rolland M,Li X,Sellier Y,Martin H,Perez-Berezo T,Rauwel B,Benchoua A,Bessières B,Aziza J,Cenac N,Luo M,Casper C,Peschanski M,Gonzalez-Dunia D,Leruez-Ville M,Davrinche C,Chavanas S

A-21271 was used in immunocytochemistry to assess activation during congenital cytomegalovirus infection of PPAR-gamma that inhibits neuronogenesis from human neural stem cells

Fri Apr 01 00:00:00 EDT 2016

Differences in the spatiotemporal expression and epistatic gene regulation of the mesodiencephalic dopaminergic precursor marker PITX3 during chicken and mouse development.

Development (Cambridge, England)

Klafke R,Prem Anand AA,Wurst W,Prakash N,Wizenmann A

A-21271 was used in immunohistochemistry to compare differences in mouse and chicken development in spatiotemporal expression and epistatic gene regulation of the mesodiencephalic dopaminergic precursor marker PITX3

Mon Feb 15 00:00:00 EST 2016

Hypothalamic radial glia function as self-renewing neural progenitors in the absence of Wnt/β-catenin signaling.

Development (Cambridge, England)

Duncan RN,Xie Y,McPherson AD,Taibi AV,Bonkowsky JL,Douglass AD,Dorsky RI

A-21271 was used in Immunohistochemistry to identify the neural progenitor cell population in the larval zebrafish hypothalamus, and to characterize the response and regulation of hypothalamic radial glia during tissue growth and regeneration.

Fri Jan 01 00:00:00 EST 2016

Thyroid Hormone Acts Locally to Increase Neurogenesis, Neuronal Differentiation, and Dendritic Arbor Elaboration in the Tadpole Visual System.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Thompson CK,Cline HT

A-21271 was used in Immunohistochemistry-wholemount to examine the role of Thyroid hormone in the neurological and visual development of Xenopus laevis tadpoles.

Wed Oct 05 00:00:00 EDT 2016

Changes in Enteric Neurons of Small Intestine in a Rat Model of Irritable Bowel Syndrome with Diarrhea.

Journal of neurogastroenterology and motility

Li S,Fei G,Fang X,Yang X,Sun X,Qian J,Wood JD,Ke M

A-21271 was used in immunohistochemistry to assess histological changes in the distal ileum and intestinal motor function in a rat model of irritable bowel syndrome with diarrhea

Sat Apr 30 00:00:00 EDT 2016

Enteric Dysfunctions in Experimental Parkinson's Disease: Alterations of Excitatory Cholinergic Neurotransmission Regulating Colonic Motility in Rats.

The Journal of pharmacology and experimental therapeutics

Fornai M,Pellegrini C,Antonioli L,Segnani C,Ippolito C,Barocelli E,Ballabeni V,Vegezzi G,Al Harraq Z,Blandini F,Levandis G,Cerri S,Blandizzi C,Bernardini N,Colucci R

A-21271 was used in immunohistochemistry to assess the impact of central dopaminergic denervation on distal colonic excitatory cholinergic neuromotor activity in rats

Mon Feb 01 00:00:00 EST 2016

The zebrafish mutant lessen: an experimental model for congenital enteric neuropathies.

Neurogastroenterology and motility

Uyttebroek L,Shepherd IT,Vanden Berghe P,Hubens G,Timmermans JP,Van Nassauw L

A-21271 was used in immunohistochemistry to elucidate the zebrafish model and congenital enteric neuropathies

Tue Mar 01 00:00:00 EST 2016

Electrophysiological and morphological changes in colonic myenteric neurons from chemotherapy-treated patients: a pilot study.

Neurogastroenterology and motility

Carbone SE,Jovanovska V,Brookes SJ,Nurgali K

A-21271 was used in Immunohistochemistry to determine whether the function and morphology of myenteric neurons was altered in specimens of the colon from chemotherapy-treated patients.

Fri Jul 01 00:00:00 EDT 2016

Reporter mouse strain provides a novel look at angiotensin type-2 receptor distribution in the central nervous system.

Brain structure & function

de Kloet AD,Wang L,Ludin JA,Smith JA,Pioquinto DJ,Hiller H,Steckelings UM,Scheuer DA,Sumners C,Krause EG

A-21271 was used in Immunohistochemistry to examine angiotensin type-2 receptor distribution in the central nervous system.

Tue Mar 01 00:00:00 EST 2016

Early developmental stress negatively affects neuronal recruitment to avian song system nucleus HVC.

Developmental neurobiology

Honarmand M,Thompson CK,Schatton A,Kipper S,Scharff C

A-21271 was used in immunohistochemistry - free floating to test if nutrition-related developmental stress impacts neurogenesis in HVC in song birds

Fri Jan 01 00:00:00 EST 2016

Neuronal labeling patterns in the spinal cord of adult transgenic Zebrafish.

Developmental neurobiology

Stil A,Drapeau P

A-21271 was used in immunocytochemistry and immunohistochemistry to describe neuronal patterns in the spinal cord of adult zebrafish.

Wed Jun 01 00:00:00 EDT 2016

Elucidation of the anatomy of a satiety network: Focus on connectivity of the parabrachial nucleus in the adult rat.

The Journal of comparative neurology

Zséli G,Vida B,Martinez A,Lechan RM,Khan AM,Fekete C

A-21271 was used in immunohistochemistry - frozen section to study the anatomy of the satiety network by focusing on connectivity of the parabrachial nucleus in the adult rat

Sat Oct 01 00:00:00 EDT 2016

L1.2, the zebrafish paralog of L1.1 and ortholog of the mammalian cell adhesion molecule L1 contributes to spinal cord regeneration in adult zebrafish.

Restorative neurology and neuroscience

Chen T,Yu Y,Hu C,Schachner M

A-21271 was used in immunohistochemistry - frozen section to study contribution to spinal cord regeneration in adult zebrafish by L1.2, the zebrafish paralog of L1.1 and ortholog of the mammalian cell adhesion molecule L1

Mon Dec 19 00:00:00 EST 2016

Molecular fingerprinting delineates progenitor populations in the developing zebrafish enteric nervous system.

Developmental dynamics : an official publication of the American Association of Anatomists

Taylor CR,Montagne WA,Eisen JS,Ganz J

A-21271 was used in Immunohistochemistry-immunofluorescence to propose that a progenitor's expression profile reveals its developmental state, and this indicates developmental restrictions.

Tue Nov 01 00:00:00 EDT 2016

Galanin regulates blood glucose level in the zebrafish: a morphological and functional study.

Histochemistry and cell biology

Podlasz P,Jakimiuk A,Chmielewska-Krzesinska M,Kasica N,Nowik N,Kaleczyc J

A-21271 was used in immunohistochemistry - frozen section to study galaninergic innervation

Fri Jan 01 00:00:00 EST 2016

Desired and side effects of the supplementation with l-glutamine and l-glutathione in enteric glia of diabetic rats.

Acta histochemica

Panizzon CPDNB,Zanoni JN,Hermes-Uliana C,Trevizan AR,Sehaber CC,Pereira RVF,Linden DR,Neto MHM

A21271 was used in immunohistochemistry to compare the effects of supplementation with l-glutamine and l-glutathione on neurons and enteric glial cells in ileum of diabetic rats

Fri Jul 01 00:00:00 EDT 2016

Zbtb20 promotes astrocytogenesis during neocortical development.

Nature communications

Nagao M,Ogata T,Sawada Y,Gotoh Y

A-21271 was used in immunohistochemistry - frozen section to study neocrotical development and promotion of astrocytogenesis by Zbtb20

Tue Mar 22 00:00:00 EDT 2016

Large-scale tissue clearing (PACT): Technical evaluation and new perspectives in immunofluorescence, histology, and ultrastructure.

Scientific reports

Neckel PH,Mattheus U,Hirt B,Just L,Mack AF

A-21271 was used in immunohistochemistry - paraffin section use CLARITY and PACT to visualize the intestinal architecture

Thu Sep 29 00:00:00 EDT 2016

Mapping of brain lipid binding protein (Blbp) in the brain of adult zebrafish, co-expression with aromatase B and links with proliferation.

Gene expression patterns : GEP

Diotel N,Vaillant C,Kah O,Pellegrini E

A-21271 was used in Immunohistochemistry-immunofluorescence to provide detailed characterization of Blbp in the entire brain and open up a broad field of research investigating the role of omega-3 polyunsaturated fatty acids in neural stem cell activity in fish.

Fri Jan 01 00:00:00 EST 2016

High content imaging quantification of multiple in vitro human neurogenesis events after neurotoxin exposure.

BMC pharmacology & toxicology

Wu X,Majumder A,Webb R,Stice SL

A-21271 was used in Immunocytochemistry to test neural active compounds in a human developmental neurotoxicity model that represents neural tube stages of vulnerability.

Thu Dec 01 00:00:00 EST 2016

Synergy between loss of NF1 and overexpression of MYCN in neuroblastoma is mediated by the GAP-related domain.

eLife

He S,Mansour MR,Zimmerman MW,Ki DH,Layden HM,Akahane K,Gjini E,de Groh ED,Perez-Atayde AR,Zhu S,Epstein JA,Look AT

A-21271 was used in immunohistochemistry - paraffin section to investigate mediation by the GAP-related domain in the synergy between loss of NF1 and overexpression of MYCN in neuroblastoma

Wed Apr 27 00:00:00 EDT 2016

Galectin-3 causes enteric neuronal loss in mice after left sided permanent middle cerebral artery occlusion, a model of stroke.

Scientific reports

Cheng X,Boza-Serrano A,Turesson MF,Deierborg T,Ekblad E,Voss U

A-21271 was used in immunohistochemistry - frozen section demonstrate that stroke results in central and peripheral galectin-3 release causing enteric neuronal loss through a TLR4-mediated mechanism

Fri Sep 09 00:00:00 EDT 2016

Active immunization against vasoactive intestinal polypeptide decreases neuronal recruitment and inhibits reproduction in zebra finches.

The Journal of comparative neurology

Vistoropsky Y,Heiblum R,Smorodinsky NI,Barnea A

A-21271 was used in Immunohistochemistry-immunofluorescence to suggest that VIP has a direct positive role in neuronal recruitment and reproduction in birds.

Mon Aug 15 00:00:00 EDT 2016

Experimental Cancer Cachexia Changes Neuron Numbers and Peptide Levels in the Intestine: Partial Protective Effects after Dietary Supplementation with L-Glutamine.

PloS one

Vicentini GE,Fracaro L,de Souza SR,Martins HA,Guarnier FA,Zanoni JN

A-21271 was used in immunohistochemistry evaluate the effect of dietary l-glutamine on the development of experimental cachexia

Mon Aug 14 00:00:00 EDT 2017

A new role of hindbrain boundaries as pools of neural stem/progenitor cells regulated by Sox2.

BMC biology

Peretz Y,Eren N,Kohl A,Hen G,Yaniv K,Weisinger K,Cinnamon Y,Sela-Donenfeld D

A-21271 was used in immunohistochemistry - frozen section to assess pools of neural stem/progenitor cells regulated by Sox2 and the novel role of hindbrain boundaries

Fri Jul 08 00:00:00 EDT 2016

Regulation of downstream neuronal genes by proneural transcription factors during initial neurogenesis in the vertebrate brain.

Neural development

Ware M,Hamdi-Rozé H,Le Friec J,David V,Dupé V

A21271 was used in immunohistochemistry - paraffin section to discuss the roles of proneural genes and their effectors during differentiation of the neuronal populations

Wed Dec 07 00:00:00 EST 2016

Cell-cycle-independent transitions in temporal identity of mammalian neural progenitor cells.

Nature communications

Okamoto M,Miyata T,Konno D,Ueda HR,Kasukawa T,Hashimoto M,Matsuzaki F,Kawaguchi A

A-21271 was used in Immunohistochemistry to suggest that the timing mechanisms controlling apical progenitors temporal identity function independently of cell-cycle progression and Notch activation mode.

Wed Apr 20 00:00:00 EDT 2016

Geminin prevents DNA damage in vagal neural crest cells to ensure normal enteric neurogenesis.

BMC biology

Konstantinidou C,Taraviras S,Pachnis V

A21271 was used in immunocytochemistry to discuss factors that impact the migratory behavior of neural crest cells

Mon Oct 24 00:00:00 EDT 2016

Modulating the expression level of secreted Wnt3 influences cerebellum development in zebrafish transgenics.

Development (Cambridge, England)

Teh C,Sun G,Shen H,Korzh V,Wohland T

A-21271 was used in Immunohistochemistry to highlight the importance of membrane-localized and secreted Wnt3 during cerebellum development.

Sun Nov 01 00:00:00 EDT 2015

The small leucine-rich repeat secreted protein Asporin induces eyes in Xenopus embryos through the IGF signalling pathway.

Development (Cambridge, England)

Luehders K,Sasai N,Davaapil H,Kurosawa-Yoshida M,Hiura H,Brah T,Ohnuma S

A-21271 was used in immunohistochemistry to examine the role of asporin in the early stages of eye development in Xenopus embryos.

Thu Oct 01 00:00:00 EDT 2015

Rbm8a haploinsufficiency disrupts embryonic cortical development resulting in microcephaly.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Mao H,Pilaz LJ,McMahon JJ,Golzio C,Wu D,Shi L,Katsanis N,Silver DL

A-21271 was used in immunocytochemistry to examine the role of q2. genes in neurogenesis.

Wed May 06 00:00:00 EDT 2015

Prototypic and arkypallidal neurons in the dopamine-intact external globus pallidus.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Abdi A,Mallet N,Mohamed FY,Sharott A,Dodson PD,Nakamura KC,Suri S,Avery SV,Larvin JT,Garas FN,Garas SN,Vinciati F,Morin S,Bezard E,Baufreton J,Magill PJ

A-21271 was used in immunohistochemistry - free floating to study prototypic and arkypallidal neurons in dopamine-intact rats

Wed Apr 29 00:00:00 EDT 2015

Parvalbumin+ Neurons and Npas1+ Neurons Are Distinct Neuron Classes in the Mouse External Globus Pallidus.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Hernández VM,Hegeman DJ,Cui Q,Kelver DA,Fiske MP,Glajch KE,Pitt JE,Huang TY,Justice NJ,Chan CS

A-21271 was used in Immunohistochemistry-floating tissue to characterise distinct neuron classes in the mouse external globus pallidus.

Wed Aug 26 00:00:00 EDT 2015

A Serotonin Circuit Acts as an Environmental Sensor to Mediate Midline Axon Crossing through EphrinB2.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Xing L,Son JH,Stevenson TJ,Lillesaar C,Bally-Cuif L,Dahl T,Bonkowsky JL

A-21271 was used in Immunohistochemistry to demonstrate that vertebrate CNS can modulate its connectivity in response to the developmental environment through serotonergic signaling.

Wed Nov 04 00:00:00 EST 2015

CTNND2-a candidate gene for reading problems and mild intellectual disability.

Journal of medical genetics

Hofmeister W,Nilsson D,Topa A,Anderlid BM,Darki F,Matsson H,Tapia Páez I,Klingberg T,Samuelsson L,Wirta V,Vezzi F,Kere J,Nordenskjöld M,Syk Lundberg E,Lindstrand A

A-21271 was used in immunohistochemistry (paraffin) to discuss cytogenetically visible chromosomal translocations.

Sun Feb 01 00:00:00 EST 2015

Depletion of the IKBKAP ortholog in zebrafish leads to hirschsprung disease-like phenotype.

World journal of gastroenterology

Cheng WW,Tang CS,Gui HS,So MT,Lui VC,Tam PK,Garcia-Barcelo MM

A-21271 was used in immunohistochemistry to determine role of IKBKAP in the development of enteric nervous system and Hirschsprung disease

Sat Feb 21 00:00:00 EST 2015

Brain-derived neurotrophic factor modulates angiotensin signaling in the hypothalamus to increase blood pressure in rats.

American journal of physiology. Heart and circulatory physiology

Erdos B,Backes I,McCowan ML,Hayward LF,Scheuer DA

A-21271 was used in immunohistochemistry to test if brain-derived neurotrophic factor in the paraventricular nucleus of the hypothalamus contributes to increases in blood pressure

Sun Mar 15 00:00:00 EDT 2015

Prolonged high fat diet ingestion, obesity, and type 2 diabetes symptoms correlate with phenotypic plasticity in myenteric neurons and nerve damage in the mouse duodenum.

Cell and tissue research

Stenkamp-Strahm CM,Nyavor YE,Kappmeyer AJ,Horton S,Gericke M,Balemba OB

A-21271 was used in immunohistochemistry (frozen) to characterize the long term effects of diabetic enteric neuropathy using mouse models.

Sat Aug 01 00:00:00 EDT 2015

Enteric glial cells are associated with stress-induced colonic hyper-contraction in maternally separated rats.

Neurogastroenterology and motility

Fujikawa Y,Tominaga K,Tanaka F,Tanigawa T,Watanabe T,Fujiwara Y,Arakawa T

A-21271 was used in immunohistochemistry to study structural and functional alterations in colonic enteric glial cells in an irritable bowel syndrome model.

Wed Jul 01 00:00:00 EDT 2015

Doublecortin is widely expressed in the developing and adult retina of sharks.

Experimental eye research

Sánchez-Farías N,Candal E

A-21271 was used in immunohistochemistry - paraffin section to investigate the role of doublecortin during neurogenesis using fishes

Fri May 01 00:00:00 EDT 2015

Developmental changes in the flotillin-1 expression pattern of the rat visual cortex.

Neuroscience

Nakadate K

A-21271 was used in immunohistochemistry to study the localization of flotillin-1 in the rat visual cortex during development

Thu Apr 30 00:00:00 EDT 2015

Wnt/ß-catenin signaling is required for radial glial neurogenesis following spinal cord injury.

Developmental biology

Briona LK,Poulain FE,Mosimann C,Dorsky RI

A-21271 was used in immunohistochemistry to investigate the role of Wnt/Beta-catenin signaling in spinal cord regeneration

Wed Jul 01 00:00:00 EDT 2015

Intrinsic and extrinsic innervation of the heart in zebrafish (Danio rerio).

The Journal of comparative neurology

Stoyek MR,Croll RP,Smith FM

A-21271 was used in immunohistochemistry to elucidate the innervation of the heart using zebrafish.

Sat Aug 01 00:00:00 EDT 2015

Expression of Cocaine and Amphetamine Regulated Transcript (CART) in the Porcine Intramural Neurons of Stomach in the Course of Experimentally Induced Diabetes Mellitus.

Journal of molecular neuroscience : MN

Bulc M,Gonkowski S,Całka J

A-21271 was used in immunohistochemistry to test the effect of streptozotocin-induced diabetes on the cocaine- and amphetamine-regulated transcript-like immunoreactive enteric nervous structures.

Sun Nov 01 00:00:00 EDT 2015

Evolutionary Conservation of the Early Axon Scaffold in the Vertebrate Brain.

Developmental dynamics : an official publication of the American Association of Anatomists

Ware M,Dupé V,Schubert FR

A-21271 was used in Immunohistochemistry-immunofluorescence to study the evolutionary conservation of the early axon scaffold in the vertebrate brain.

Thu Oct 01 00:00:00 EDT 2015

Evolutionary Conservation of the Early Axon Scaffold in the Vertebrate Brain.

Developmental dynamics : an official publication of the American Association of Anatomists

Ware M,Dupé V,Schubert FR

A-21271 was used in Immunohistochemistry-immunofluorescence to study the evolutionary conservation of the early axon scaffold in the vertebrate brain.

Thu Oct 01 00:00:00 EDT 2015

Evolutionary Conservation of the Early Axon Scaffold in the Vertebrate Brain.

Developmental dynamics : an official publication of the American Association of Anatomists

Ware M,Dupé V,Schubert FR

A-21271 was used in Immunohistochemistry-immunofluorescence to study the evolutionary conservation of the early axon scaffold in the vertebrate brain.

Thu Oct 01 00:00:00 EDT 2015

Evolutionary Conservation of the Early Axon Scaffold in the Vertebrate Brain.

Developmental dynamics : an official publication of the American Association of Anatomists

Ware M,Dupé V,Schubert FR

A-21271 was used in Immunohistochemistry-immunofluorescence to study the evolutionary conservation of the early axon scaffold in the vertebrate brain.

Thu Oct 01 00:00:00 EDT 2015

Excitatory and inhibitory enteric innervation of horse lower esophageal sphincter.

Histochemistry and cell biology

Chiocchetti R,Giancola F,Mazzoni M,Sorteni C,Romagnoli N,Pietra M

A-21271 was used in immunohistochemistry to study the lower esophageal sphincter of horses.

Mon Jun 01 00:00:00 EDT 2015

Luteinizing hormone receptors are expressed in rat myenteric neurons and mediate neuronal loss.

Autonomic neuroscience : basic & clinical

Sand E,Voss U,Ohlsson B,Ekblad E

A-21271 was used in immunocytochemistry to study the luteinizing hormone receptor in rat myenteric neurons.

Tue Dec 01 00:00:00 EST 2015

Human Embryonic Stem Cell-Derived Progenitors Assist Functional Sensory Axon Regeneration after Dorsal Root Avulsion Injury.

Scientific reports

Hoeber J,Trolle C,Konig N,Du Z,Gallo A,Hermans E,Aldskogius H,Shortland P,Zhang SC,Deumens R,Kozlova EN

A-21271 was used in immunohistochemistry to assess dorsal root avulsion injury and how human embryonic stem cell-derived progenitors assist functional sensory axo regeneration

Mon Jun 08 00:00:00 EDT 2015

A Branching Process to Characterize the Dynamics of Stem Cell Differentiation.

Scientific reports

Míguez DG

A-21271 was used in immunohistochemistry to create a mathematical model that predicts the average rates of proliferative and differentiative divisions in stem cell population

Wed Aug 19 00:00:00 EDT 2015

Architecture and Chemical Coding of the Inner and Outer Submucous Plexus in the Colon of Piglets.

PloS one

Petto C,Gäbel G,Pfannkuche H

A-21271 was used in immunohistochemistry to determine the expression and co-localization of different neurotransmitters and neuronal markers in the inner submucous plexus, the outer submucous plexus and neuronal fibers

Fri May 06 00:00:00 EDT 2016

Disruptive CHD8 mutations define a subtype of autism early in development.

Cell

Bernier R,Golzio C,Xiong B,Stessman HA,Coe BP,Penn O,Witherspoon K,Gerdts J,Baker C,Vulto-van Silfhout AT,Schuurs-Hoeijmakers JH,Fichera M,Bosco P,Buono S,Alberti A,Failla P,Peeters H,Steyaert J,Vissers LELM,Francescatto L,Mefford HC,Rosenfeld JA,Bakken T,O'Roak BJ,Pawlus M,Moon R,Shendure J,Amaral DG,Lein E,Rankin J,Romano C,de Vries BBA,Katsanis N,Eichler EE

A-21271 was used in immunocytochemistry to identify CHD8 disruptions in a distinct autism spectrum disorder subtype and reveal comorbidities between brain development and enteric innervation

Thu Jul 17 00:00:00 EDT 2014

Deletion of the von Hippel-Lindau gene causes sympathoadrenal cell death and impairs chemoreceptor-mediated adaptation to hypoxia.

EMBO molecular medicine

Macías D,Fernández-Agüera MC,Bonilla-Henao V,López-Barneo J

A-21271 was used in immunohistochemistry - paraffin section to examine the contribution of the von Hippel-Lindau gene to sympathoadrenal homeostasis

Mon Dec 01 00:00:00 EST 2014

Mutations in QARS, encoding glutaminyl-tRNA synthetase, cause progressive microcephaly, cerebral-cerebellar atrophy, and intractable seizures.

American journal of human genetics

Zhang X,Ling J,Barcia G,Jing L,Wu J,Barry BJ,Mochida GH,Hill RS,Weimer JM,Stein Q,Poduri A,Partlow JN,Ville D,Dulac O,Yu TW,Lam AT,Servattalab S,Rodriguez J,Boddaert N,Munnich A,Colleaux L,Zon LI,Söll D,Walsh CA,Nabbout R

A-21271 was used in immunocytochemistry to identify QARS (encoding glutaminyl-tRNA synthetase [QARS]) mutations in two unrelated families affected by progressive microcephaly

Thu Apr 03 00:00:00 EDT 2014

Ewing sarcoma of the small bowel: a study of seven cases, including one with the uncommonly reported EWSR1-FEV translocation.

Histopathology

Milione M,Gasparini P,Sozzi G,Mazzaferro V,Ferrari A,Casali PG,Perrone F,Tamborini E,Pellegrinelli A,Gherardi G,Arrigoni G,Collini P,Testi A,De Paoli E,Aiello A,Pilotti S,Pelosi G

A-21271 was used in immunohistochemistry to discuss Ewing sarcoma.

Sun Jun 01 00:00:00 EDT 2014

An increase in MECP2 dosage impairs neural tube formation.

Neurobiology of disease

Petazzi P,Akizu N,García A,Estarás C,Martínez de Paz A,Rodríguez-Paredes M,Martínez-Balbás MA,Huertas D,Esteller M

A-21271 was used in immunocytochemistry to study the effects of increased MECP2 on development of the nervous system

Tue Jul 01 00:00:00 EDT 2014

Exclusive multipotency and preferential asymmetric divisions in post-embryonic neural stem cells of the fish retina.

Development (Cambridge, England)

Centanin L,Ander JJ,Hoeckendorf B,Lust K,Kellner T,Kraemer I,Urbany C,Hasel E,Harris WA,Simons BD,Wittbrodt J

A-21271 was used in immunocytochemistry to develop a clonal labeling and non-invasive fate tracking system and study post-embryonic stem cells in the retina

Mon Sep 01 00:00:00 EDT 2014

Activated retinoid receptors are required for the migration and fate maintenance of subsets of cortical neurons.

Development (Cambridge, England)

Choi J,Park S,Sockanathan S

A-21271 was used in Immunohistochemistry-immunofluorescence to suggest that retinoic acid signalling pathways operate postmitotically to regulate radial migration and consolidate regional differences in cortical neuronal identity.

Sat Mar 01 00:00:00 EST 2014

Radial glial progenitors repair the zebrafish spinal cord following transection.

Experimental neurology

Briona LK,Dorsky RI

A-21271 was used in immunohistochemistry - frozen section to investigate the role of Dbx1 in neurogenesis in zebrafish

Sun Jun 01 00:00:00 EDT 2014

Induced pluripotency in chicken embryonic fibroblast results in a germ cell fate.

Stem cells and development

Lu Y,West FD,Jordan BJ,Jordan ET,West RC,Yu P,He Y,Barrios MA,Zhu Z,Petitte JN,Beckstead RB,Stice SL

A-21271 was used in immunocytochemistry to study the mechanisms that regulate the acquisition and maintenance germ cell character

Fri Aug 01 00:00:00 EDT 2014

Human enteric neurons: morphological, electrophysiological, and neurochemical identification.

Neurogastroenterology and motility

Carbone SE,Jovanovska V,Nurgali K,Brookes SJ

A-21271 was used in immunohistochemistry to describe a method to study neurons in the intact myenteric plexus of human colon ex vivo.

Mon Dec 01 00:00:00 EST 2014

Oestradiol and diet modulate energy homeostasis and hypothalamic neurogenesis in the adult female mouse.

Journal of neuroendocrinology

Bless EP,Reddy T,Acharya KD,Beltz BS,Tetel MJ

A-21271 was used in immunohistochemistry - frozen section to test if diet and hormonal status modulate hypothalamic neurogenesis in the adult female mouse

Sat Nov 01 00:00:00 EDT 2014

Developmental, tract-tracing and immunohistochemical study of the peripheral olfactory system in a basal vertebrate: insights on Pax6 neurons migrating along the olfactory nerve.

Brain structure & function

Quintana-Urzainqui I,Rodríguez-Moldes I,Candal E

A-21271 was used in immunohistochemistry - paraffin section to study the development of the olfactory system in Scyliorhinus canicula

Wed Jan 01 00:00:00 EST 2014

Estradiol treatment decreases cell proliferation in the neurogenic zones of adult female zebrafish (Danio rerio) brain.

Neuroscience

Makantasi P,Dermon CR

A-21271 was used in immunohistochemistry to determine the effects pf estrogen in adult brain proliferation zones

Fri Sep 26 00:00:00 EDT 2014

Cell death, cavitation and spontaneous multi-differentiation of dental pulp stem cells-derived spheroids in vitro: a journey to survival and organogenesis.

Biology of the cell

Xiao L,Kumazawa Y,Okamura H

A-21271 was used in immunohistochemistry to examine cavitation and differentiation of human dental pulp stem cells

Mon Dec 01 00:00:00 EST 2014

Age-related changes in stem cell dynamics, neurogenesis, apoptosis, and gliosis in the adult brain: a novel teleost fish model of negligible senescence.

Developmental neurobiology

Traniello IM,Sîrbulescu RF,Ilieş I,Zupanc GK

A-21271 was used in immunohistochemistry to assess the age-related changes associated with adult neurogenesis in the brain of brown ghost knifefish.

Thu May 01 00:00:00 EDT 2014

Regulation of later neurogenic stages of adult-derived neural stem/progenitor cells by L-type Ca2+ channels.

Development, growth & differentiation

Teh DB,Ishizuka T,Yawo H

A-21271 was used in immunocytochemistry to determine which stage of neurogenesis is under the regulation of L-type Ca2+ channels.

Wed Oct 01 00:00:00 EDT 2014

DCX-expressing cells in the vicinity of the hypothalamic neurogenic niche: a comparative study between mouse, sheep, and human tissues.

The Journal of comparative neurology

Batailler M,Droguerre M,Baroncini M,Fontaine C,Prevot V,Migaud M

A-21271 was used in immunohistochemistry - frozen section to study the expression of the neuroblast marker doublecortin in adult ovine, mouse, and human hypothalamic tissues.

Sun Jun 01 00:00:00 EDT 2014

Spatiotemporal distribution of SUMOylation components during mouse brain development.

The Journal of comparative neurology

Hasegawa Y,Yoshida D,Nakamura Y,Sakakibara S

A-21271 was used in immunohistochemistry to profile SUMOylation components during mouse brain development.

Mon Sep 01 00:00:00 EDT 2014

Piezo2 expression in corneal afferent neurons.

The Journal of comparative neurology

Bron R,Wood RJ,Brock JA,Ivanusic JJ

A-21271 was used in Immunohistochemistry-immunofluorescence to provide the first evidence in an in vivo system that Piezo2 is a strong candidate for a channel that transduces noxious mechanical stimuli.

Mon Sep 01 00:00:00 EDT 2014

Regional innervation of the heart in the goldfish, Carassius auratus: a confocal microscopy study.

The Journal of comparative neurology

Newton CM,Stoyek MR,Croll RP,Smith FM

A-21271 was used in immunohistochemistry to report the innervation patterns in the heart of the goldfish.

Sat Feb 01 00:00:00 EST 2014

Parcellation of cerebellins 1, 2, and 4 among different subpopulations of dorsal horn neurons in mouse spinal cord.

The Journal of comparative neurology

Cagle MC,Honig MG

A-21271 was used in immunohistochemistry to study the function of cerebellins in the cerebellum and striatum

Sat Feb 01 00:00:00 EST 2014

Development of the cerebellar afferent system in the shark Scyliorhinus canicula: insights into the basal organization of precerebellar nuclei in gnathostomes.

The Journal of comparative neurology

Pose-Méndez S,Candal E,Adrio F,Rodríguez-Moldes I

A-21271 was used in immunohistochemistry to study the cerebellar connections in shark embryos and juveniles

Wed Jan 01 00:00:00 EST 2014

PTEN inhibition enhances neurite outgrowth in human embryonic stem cell-derived neuronal progenitor cells.

The Journal of comparative neurology

Wyatt LA,Filbin MT,Keirstead HS

A-21271 was used in immunocytochemistry to study the role of PTEN in neurite outgrowth in human embryonic stem cell-derived neuronal progenitor cells

Fri Aug 15 00:00:00 EDT 2014

Characterization of a novel primary culture system of adult zebrafish brainstem cells.

Journal of neuroscience methods

Tapanes-Castillo A,Shabazz FS,Mboge MY,Vajn K,Oudega M,Plunkett JA

A-21271 was used in immunocytochemistry to describe a brainstem culture model to study axonal growth, neurogenesis, and regeneration of the adult zebrafish central nervous system.

Sat Feb 15 00:00:00 EST 2014

Large-scale identification of proteins involved in the development of a sexually dimorphic behavior.

Journal of neurophysiology

Zupanc GK,Ilies I,Sîrbulescu RF,Zupanc MM

A-21271 was used in immunohistochemistry (frozen) to identify proteins involved in the development of a sexually dimorphic behavior using the brown ghost knifefish.

Tue Apr 01 00:00:00 EDT 2014

Enteric neuroplasticity in seawater-adapted European eel (Anguilla anguilla).

Journal of anatomy

Sorteni C,Clavenzani P,De Giorgio R,Portnoy O,Sirri R,Mordenti O,Di Biase A,Parmeggiani A,Menconi V,Chiocchetti R

A-21271 was used in immunohistochemistry (frozen) to use European eels to understand the adaptive changes of the enteric nervous system to modified salinity and starvation.

Sat Feb 01 00:00:00 EST 2014

Proteinase-activated receptor 2 expression in the intestinal tract of the horse.

Research in veterinary science

Zannoni A,Bombardi C,Dondi F,Morini M,Forni M,Chiocchetti R,Spadari A,Romagnoli N

A-21271 was used in immunohistochemistry to study the equine intestinal expression of PAR2.

Sun Jun 01 00:00:00 EDT 2014

Directing mouse embryonic neurosphere differentiation toward an enriched neuronal population.

International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience

Torrado EF,Gomes C,Santos G,Fernandes A,Brites D,Falcão AS

A-21271 was used in immunocytochemistry to describe the development a neurosphere culture method that results in highly proliferative stem/progenitor cell population

Wed Oct 01 00:00:00 EDT 2014

Co-expression patterns of cocaine- and amphetamine-regulated transcript (CART) with neuropeptides in dorsal root ganglia of the pig.

Acta histochemica

Zacharko-Siembida A,Kulik P,Szalak R,Lalak R,Arciszewski MB

A-21271 was used in immunohistochemistry - frozen section to determine the neuronal distribution of CART in porcine dorsal root ganglia

Sat Mar 01 00:00:00 EST 2014

Differential responsiveness of distinct retinal domains to Atoh7.

Mechanisms of development

Sinn R,Peravali R,Heermann S,Wittbrodt J

A-21271 was used in immunohistochemistry to explore the differential susceptibilities of early retinal progenitor cells to Atoh7 in vivo

Fri Aug 01 00:00:00 EDT 2014

Immunoreactivity to cocaine- and amphetamine-regulated transcript in the enteric nervous system of the pig and wild boar stomach.

Anatomia, histologia, embryologia

Zacharko-Siembida A,Arciszewski MB

A-21271 was used in immunohistochemistry - frozen section to study the distribution patterns of cocaine- and amphetamine-regulated transcript in the stomach of the pig and wild boar

Sat Feb 01 00:00:00 EST 2014

Sustained Wnt/β-catenin signalling causes neuroepithelial aberrations through the accumulation of aPKC at the apical pole.

Nature communications

Herrera A,Saade M,Menendez A,Marti E,Pons S

A-21271 was used in immunohistochemistry to report that beta-catenin controls the cell fate and polarity of neuroblasts by modulating the expression and localization of aPKC.

Thu Jun 19 00:00:00 EDT 2014

De novo SOX11 mutations cause Coffin-Siris syndrome.

Nature communications

Tsurusaki Y,Koshimizu E,Ohashi H,Phadke S,Kou I,Shiina M,Suzuki T,Okamoto N,Imamura S,Yamashita M,Watanabe S,Yoshiura K,Kodera H,Miyatake S,Nakashima M,Saitsu H,Ogata K,Ikegawa S,Miyake N,Matsumoto N

A-21271 was used in immunohistochemistry to investigate the impact of the BAF complex and SOX11 transcriptional network in brain development.

Mon Jun 02 00:00:00 EDT 2014

Two cases of multinodular and vacuolating neuronal tumour.

Acta neuropathologica communications

Bodi I,Curran O,Selway R,Elwes R,Burrone J,Laxton R,Al-Sarraj S,Honavar M

A-21271 was used in immunohistochemistry (paraffin) to characterize two patients with multinodular and vacuolating neuronal tumors.

Mon Jan 20 00:00:00 EST 2014

Acetylcholine serves as a derepressor in Loperamide-induced Opioid-Induced Bowel Dysfunction (OIBD) in zebrafish.

Scientific reports

Shi Y,Zhang Y,Zhao F,Ruan H,Huang H,Luo L,Li L

A-21271 was used in immunocytochemistry to establish a model to study the effects of opioids on the gut development and peristalsis using zebrafish

Mon Jul 07 00:00:00 EDT 2014

Cytoskeletal regulation by AUTS2 in neuronal migration and neuritogenesis.

Cell reports

Hori K,Nagai T,Shan W,Sakamoto A,Taya S,Hashimoto R,Hayashi T,Abe M,Yamazaki M,Nakao K,Nishioka T,Sakimura K,Yamada K,Kaibuchi K,Hoshino M

A-21271 was used in Immunohistochemistry to demonstrate a role for cytoplasmic AUTS2 in the regulation of Rho family GTPases contributing to neural development.

Wed Dec 24 00:00:00 EST 2014

A method for exploring adult neurogenesis in the songbird brain.

Cold Spring Harbor protocols

Asik K,Rao JL,Kirn JR

A-21271 was used in immunohistochemistry to describe a method to study adult neurogenesis using avian brains

Thu Oct 23 00:00:00 EDT 2014

BMP signaling in astrocytes downregulates EGFR to modulate survival and maturation.

PloS one

Scholze AR,Foo LC,Mulinyawe S,Barres BA

A-21271 was used in immunocytochemistry to show that fibroblast growth factors and bone morphogenetic proteins contribute to astrocyte development

Tue Dec 22 00:00:00 EST 2015

Hirschsprung-like disease is exacerbated by reduced de novo GMP synthesis.

The Journal of clinical investigation

Lake JI,Tusheva OA,Graham BL,Heuckeroth RO

A-21271 was used in immunohistochemistry to test if nongenetic factors might contribute to Hirschsprung disease using a zebrafish model.

Fri Nov 01 00:00:00 EDT 2013

A zebrafish model of CLN2 disease is deficient in tripeptidyl peptidase 1 and displays progressive neurodegeneration accompanied by a reduction in proliferation.

Brain : a journal of neurology

Mahmood F,Fu S,Cooke J,Wilson SW,Cooper JD,Russell C

A-21271 was used in Immunohistochemistry-immunofluorescence to provide proof-of-principle that tpp1(sa0011)(-/-) mutants can utilize the advantages of zebrafish for understanding pathogenesis and drug discovery in CLN2 disease.

Wed May 01 00:00:00 EDT 2013

Exonic deletions in AUTS2 cause a syndromic form of intellectual disability and suggest a critical role for the C terminus.

American journal of human genetics

Beunders G,Voorhoeve E,Golzio C,Pardo LM,Rosenfeld JA,Talkowski ME,Simonic I,Lionel AC,Vergult S,Pyatt RE,van de Kamp J,Nieuwint A,Weiss MM,Rizzu P,Verwer LE,van Spaendonk RM,Shen Y,Wu BL,Yu T,Yu Y,Chiang C,Gusella JF,Lindgren AM,Morton CC,van Binsbergen E,Bulk S,van Rossem E,Vanakker O,Armstrong R,Park SM,Greenhalgh L,Maye U,Neill NJ,Abbott KM,Sell S,Ladda R,Farber DM,Bader PI,Cushing T,Drautz JM,Konczal L,Nash P,de Los Reyes E,Carter MT,Hopkins E,Marshall CR,Osborne LR,Gripp KW,Thrush DL,Hashimoto S,Gastier-Foster JM,Astbury C,Ylstra B,Meijers-Heijboer H,Posthuma D,Menten B,Mortier G,Scherer SW,Eichler EE,Girirajan S,Katsanis N,Groffen AJ,Sistermans EA

A-21271 was used in immunohistochemistry to show a causal role of AUTS2 in neurocognitive disorders.

Thu Feb 07 00:00:00 EST 2013

Modulation of dorsal root ganglion development by ErbB signaling and the scaffold protein Sorbs3.

Development (Cambridge, England)

Malmquist SJ,Abramsson A,McGraw HF,Linbo TH,Raible DW

A-21271 was used in Immunohistochemistry to propose a model in which Sorbs3 helps to integrate ErbB signals to promote DRG neurogenesis through the activation of MAPK and upregulation of neurogenin1.

Tue Oct 01 00:00:00 EDT 2013

Cell delamination in the mesencephalic neural fold and its implication for the origin of ectomesenchyme.

Development (Cambridge, England)

Lee RT,Nagai H,Nakaya Y,Sheng G,Trainor PA,Weston JA,Thiery JP

A-21271 was used in immunohistochemistry (frozen) to investigate what defines the neural crest and the origin of the ectomesenchyme in mice and chickens.

Sun Dec 01 00:00:00 EST 2013

An inducible transgene expression system for zebrafish and chick.

Development (Cambridge, England)

Gerety SS,Breau MA,Sasai N,Xu Q,Briscoe J,Wilkinson DG

A-21271 was used in immunohistochemistry to develop an inducible system to control the timing of transgene expression in zebrafish and chicks.

Wed May 01 00:00:00 EDT 2013

Indian hedgehog B function is required for the specification of oligodendrocyte progenitor cells in the zebrafish CNS.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Chung AY,Kim S,Kim E,Kim D,Jeong I,Cha YR,Bae YK,Park SW,Lee J,Park HC

A-21271 was used in immunohistochemistry to study the generation of motor neurons and oligodendrocytes.

Wed Jan 23 00:00:00 EST 2013

Smad2 and Smad3 cooperate and antagonize simultaneously in vertebrate neurogenesis.

Journal of cell science

Míguez DG,Gil-Guiñón E,Pons S,Martí E

A-21271 was used in immunohistochemistry to elucidate the role of transforming growth factor beta during neurogenesis.

Sun Dec 01 00:00:00 EST 2013

MicroRNA 22 regulates cell cycle length in cerebellar granular neuron precursors.

Molecular and cellular biology

Berenguer J,Herrera A,Vuolo L,Torroba B,Llorens F,Sumoy L,Pons S

A-21271 was used in immunocytochemistry to elucidate the BMP antimitotic mechanism.

Mon Jul 01 00:00:00 EDT 2013

Mast cell expression of the serotonin1A receptor in guinea pig and human intestine.

American journal of physiology. Gastrointestinal and liver physiology

Wang GD,Wang XY,Zou F,Qu M,Liu S,Fei G,Xia Y,Needleman BJ,Mikami DJ,Wood JD

A-21271 was used in immunohistochemistry to study the role of serotonin on enteric mast cells.

Wed May 15 00:00:00 EDT 2013

Characterization of human dental pulp cells-derived spheroids in serum-free medium: stem cells in the core.

Journal of cellular biochemistry

Xiao L,Tsutsui T

A-21271 was used in immunohistochemistry - paraffin section to study the dynamics, cell distribution, molecular profiles, and neuronal/osteogenic potential of spheroids generated from human dental pulp.

Fri Nov 01 00:00:00 EDT 2013

Intracerebral transplantation of differentiated human embryonic stem cells to hemiparkinsonian monkeys.

Cell transplantation

Emborg ME,Zhang Z,Joers V,Brunner K,Bondarenko V,Ohshima S,Zhang SC

A-21271 was used in immunohistochemistry to assess the use of stem cell therapy for Parkinson's disease using rhesus monkeys.

Mon Dec 23 00:00:00 EST 2013

High-fat diet ingestion correlates with neuropathy in the duodenum myenteric plexus of obese mice with symptoms of type 2 diabetes.

Cell and tissue research

Stenkamp-Strahm CM,Kappmeyer AJ,Schmalz JT,Gericke M,Balemba O

A-21271 was used in Immunohistochemistry to correlate high-fat diet ingestion, obesity and type 2 diabetes symptoms with a loss of duodenal neurons.

Fri Nov 01 00:00:00 EDT 2013

Myenteric neuron numbers are maintained in aging mouse distal colon.

Neurogastroenterology and motility

Gamage PP,Ranson RN,Patel BA,Yeoman MS,Saffrey MJ

A-21271 was used in immunocytochemistry to examine neurons in the mouse distal colon during aging.

Mon Jul 01 00:00:00 EDT 2013

Sexually dimorphic and developmentally regulated expression of tubulin-specific chaperone protein A in the LMAN of zebra finches.

Neuroscience

Qi LM,Wade J

A-21271 was used in immunocytochemistry to test if the Z-gene contributes to sexual differentiation of the song system.

Thu Sep 05 00:00:00 EDT 2013

Dner inhibits neural progenitor proliferation and induces neuronal and glial differentiation in zebrafish.

Developmental biology

Hsieh FY,Ma TL,Shih HY,Lin SJ,Huang CW,Wang HY,Cheng YC

A-21271 was used in immunohistochemistry to investigate the role of Delta/notch-like epidermal growth factor-related receptor in the developing Drosophilia nervous system.

Fri Mar 01 00:00:00 EST 2013

Coexpression of Runx1 and Runx3 in mechanoreceptive dorsal root ganglion neurons.

Developmental neurobiology

Yoshikawa M,Murakami Y,Senzaki K,Masuda T,Ozaki S,Ito Y,Shiga T

A-21271 was used in immunohistochemistry - frozen section to examine the expression of Runx and Runx3 in the mouse dorsal root ganglion during embryonic and postnatal development.

Sat Jun 01 00:00:00 EDT 2013

Expression of β2 adrenoceptors within enteric neurons of the horse ileum.

Research in veterinary science

Bombardi C,Grandis A,Gardini A,Sorteni C,Clavenzani P,Chiocchetti R

A-21271 was used in immunohistochemistry (frozen) to study adrenergic receptors in the horse intestine.

Sun Dec 01 00:00:00 EST 2013

Neurochemistry of myenteric plexus neurons of bank vole (Myodes glareolus) ileum.

Research in veterinary science

Sadeghinezhad J,Sorteni C,Di Guardo G,D'Agostino C,Agrimi U,Nonno R,Chiocchetti R

A-21271 was used in immunohistochemistry to describe the phenotype of ileal myenteric plexus neuronal cells and fibers of the bank vole.

Sun Dec 01 00:00:00 EST 2013

High-fat diet and age-dependent effects on enteric glial cell populations of mouse small intestine.

Autonomic neuroscience : basic & clinical

Stenkamp-Strahm C,Patterson S,Boren J,Gericke M,Balemba O

A-21271 was used in immunohistochemistry to report that mucosal glia cell damage occurs during diabetic symptoms.

Tue Oct 01 00:00:00 EDT 2013

Characterization of enteric neurons in wild-type and mutant zebrafish using semi-automated cell counting and co-expression analysis.

Zebrafish

Simonson LW,Ganz J,Melancon E,Eisen JS

A-21271 was used in immunohistochemistry to develop tools to study fluorescent enteric neurons in zebrafish.

Sat Jun 01 00:00:00 EDT 2013

Immunolocalization of NOS, VIP, galanin and SP in the small intestine of suckling pigs treated with red kidney bean (Phaseolus vulgaris) lectin.

Acta histochemica

Zacharko-Siembida A,Valverde Piedra JL,Szymańczyk S,Arciszewski MB

A-21271 was used in immunohistochemistry - frozen section to test if treatment with red kidney bean lectin influences the chemical code of the small intestine nervous system of suckling pigs.

Mon Apr 01 00:00:00 EDT 2013

Intrinsic innervation of the Persian squirrel (Sciurus anomalus) ileum.

Anatomia, histologia, embryologia

Sadeghinezhad J,Tootian Z,Latorre R,Sorteni C,Chiocchetti R

A-21271 was used in immunohistochemistry to study the enteric nervous system of wild or 'unconventional' rodents.

Sat Jun 01 00:00:00 EDT 2013

Changes in expression of calbindin 28 kDa in the small intestine of red kidney bean (Phaseolus vulgaris) lectin-treated suckling piglets.

Polish journal of veterinary sciences

Zacharko-Siembida A,Piedra JL,Arciszewski MB

A-21271 was used in immunohistochemistry - frozen section to investigate calbindin expression in the pig gastrointestinal tract.

Thu Sep 05 00:00:00 EDT 2013

Mmp17b is essential for proper neural crest cell migration in vivo.

PloS one

Leigh NR,Schupp MO,Li K,Padmanabhan V,Gastonguay A,Wang L,Chun CZ,Wilkinson GA,Ramchandran R

A-21271 was used in immunohistochemistry to investigate the role of matrix metalloproteinase 17b to neural crest cell migration in zebrafish.

Mon Jul 28 00:00:00 EDT 2014

Zebrafish as a model for monocarboxyl transporter 8-deficiency.

The Journal of biological chemistry

Vatine GD,Zada D,Lerer-Goldshtein T,Tovin A,Malkinson G,Yaniv K,Appelbaum L

A-21271 was used in western blot to show that MCT8 deficient zebrafish exhibit a neurological phenotype.

Fri Jan 04 00:00:00 EST 2013

KCTD13 is a major driver of mirrored neuroanatomical phenotypes of the 16p11.2 copy number variant.

Nature

Golzio C,Willer J,Talkowski ME,Oh EC,Taniguchi Y,Jacquemont S,Reymond A,Sun M,Sawa A,Gusella JF,Kamiya A,Beckmann JS,Katsanis N

A-21271 was used in immunohistochemistry to study the effects of KCTD3 copy number in zebrafish.

Wed May 16 00:00:00 EDT 2012

Stab wound injury of the zebrafish telencephalon: a model for comparative analysis of reactive gliosis.

Glia

Baumgart EV,Barbosa JS,Bally-Cuif L,Götz M,Ninkovic J

A-21271 was used in immunohistochemistry to study glial responses using an invasive stab wound model.

Thu Mar 01 00:00:00 EST 2012

Transcriptional regulatory mechanisms underlying the GABAergic neuron fate in different diencephalic prosomeres.

Development (Cambridge, England)

Virolainen SM,Achim K,Peltopuro P,Salminen M,Partanen J

A-21271 was used in immunohistochemistry to study the fate of GABAergic neurons in different diencephalic prosomeres and the transcriptional mechanisms involved.

Mon Oct 01 00:00:00 EDT 2012

Genome-wide analysis reveals that Smad3 and JMJD3 HDM co-activate the neural developmental program.

Development (Cambridge, England)

Estarás C,Akizu N,García A,Beltrán S,de la Cruz X,Martínez-Balbás MA

A-21271 was used in Immunohistochemistry to indicate that JMJD3 function is required for the TGFΒ developmental program to proceed.

Wed Aug 01 00:00:00 EDT 2012

Signalling from hindbrain boundaries regulates neuronal clustering that patterns neurogenesis.

Development (Cambridge, England)

Terriente J,Gerety SS,Watanabe-Asaka T,Gonzalez-Quevedo R,Wilkinson DG

A-21271 was used in immunohistochemistry to investigate how fgf20a-expressing neurons in segment centers cluster.

Wed Aug 01 00:00:00 EDT 2012

Antagonistic regulation of PAF1C and p-TEFb is required for oligodendrocyte differentiation.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Kim S,Kim JD,Chung AY,Kim HS,Kim YS,Kim MJ,Koun S,Lee YM,Rhee M,Park HC,Huh TL

A-21271 was used in immunohistochemistry to elucidate mechanisms underlying oligodendrocyte differentiation.

Wed Jun 13 00:00:00 EDT 2012

Wandering neuronal migration in the postnatal vertebrate forebrain.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Scott BB,Gardner T,Ji N,Fee MS,Lois C

A-21271 was used in immunohistochemistry to study how new neurons migrate through the mature brain and integrate.

Wed Jan 25 00:00:00 EST 2012

Self-renewal and differentiation of reactive astrocyte-derived neural stem/progenitor cells isolated from the cortical peri-infarct area after stroke.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Shimada IS,LeComte MD,Granger JC,Quinlan NJ,Spees JL

A-21271 was used in immunohistochemistry to study the self-renewal and differentiation of reactive astrocyte-derived neural stem/progenitor cells isolated after stroke.

Wed Jun 06 00:00:00 EDT 2012

Immunohistochemical analysis of myenteric ganglia and interstitial cells of Cajal in ulcerative colitis.

Journal of cellular and molecular medicine

Bernardini N,Segnani C,Ippolito C,De Giorgio R,Colucci R,Faussone-Pellegrini MS,Chiarugi M,Campani D,Castagna M,Mattii L,Blandizzi C,Dolfi A

A-21271 was used in immunohistochemistry to examine the neural-glial components of myenteric ganglia and interstitial cells of Cajal in patients with ulcerative colitis.

Wed Feb 01 00:00:00 EST 2012

Cell proliferation pattern in adult zebrafish forebrain is sexually dimorphic.

Neuroscience

Ampatzis K,Makantasi P,Dermon CR

A-21271 was used in immunohistochemistry to examine if sex differences in cell proliferation represents a conserved feature of adult brain plasticity.

Thu Dec 13 00:00:00 EST 2012

MANF regulates dopaminergic neuron development in larval zebrafish.

Developmental biology

Chen YC,Sundvik M,Rozov S,Priyadarshini M,Panula P

A-21271 was used in immunohistochemistry to study the role of MANF during dopaminergic neuron development in larval zebrafish.

Mon Oct 15 00:00:00 EDT 2012

Birth of neural progenitors during the embryonic period of sexual differentiation in the Japanese quail brain.

The Journal of comparative neurology

Bardet SM,Mouriec K,Balthazart J

A-21271 was used in immunohistochemistry to investigate the ontogeny of diencephalic brain nuclei using quail.

Sat Dec 15 00:00:00 EST 2012

Galanin gene expression and effects of its knock-down on the development of the nervous system in larval zebrafish.

The Journal of comparative neurology

Podlasz P,Sallinen V,Chen YC,Kudo H,Fedorowska N,Panula P

A-21271 was used in immunocytochemistry to assess the role of galanin in developing zebrafish.

Sat Dec 01 00:00:00 EST 2012

Neuronal and glial differentiation during lizard (Gallotia galloti) visual system ontogeny.

The Journal of comparative neurology

Romero-Alemán MM,Monzón-Mayor M,Santos E,Lang DM,Yanes C

A-21271 was used in immunohistochemistry to study the histogenesis of the lizard visual system.

Sun Jul 01 00:00:00 EDT 2012

olig2-Expressing hindbrain cells are required for migrating facial motor neurons.

Developmental dynamics : an official publication of the American Association of Anatomists

Zannino DA,Sagerström CG,Appel B

A-21271 was used in immunohistochemistry to show that olig2 function contributes to the migration of facial motor neurons.

Wed Feb 01 00:00:00 EST 2012

Adult neurogenesis in the brain of the Mozambique tilapia, Oreochromis mossambicus.

Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology

Teles MC,Sîrbulescu RF,Wellbrock UM,Oliveira RF,Zupanc GK

A-21271 was used in immunohistochemistry to study the generation, migration, and differentiation of new neurons and glial cells in the Mozambique tilapia.

Fri Jun 01 00:00:00 EDT 2012

Intestinal dysmotility and enteric neurochemical changes in a Parkinson's disease rat model.

Autonomic neuroscience : basic & clinical

Colucci M,Cervio M,Faniglione M,De Angelis S,Pajoro M,Levandis G,Tassorelli C,Blandini F,Feletti F,De Giorgio R,Dellabianca A,Tonini S,Tonini M

A-21271 was used in immunocytochemistry to investigate mechanisms underlying the enteric neurochemical plasticity events evoked by disruption of the normal brain-gut cross-talk.

Thu Aug 16 00:00:00 EDT 2012

Macrophages associated with the intrinsic and extrinsic autonomic innervation of the rat gastrointestinal tract.

Autonomic neuroscience : basic & clinical

Phillips RJ,Powley TL

A-21271 was used in immunohistochemistry - free floating to study interactions between macrophages and the autonomic innervation of gastrointestinal tract smooth muscle.

Mon Jul 02 00:00:00 EDT 2012

Spinal transection induces widespread proliferation of cells along the length of the spinal cord in a weakly electric fish.

Brain, behavior and evolution

Allen AR,Smith GT

A-21271 was used in immunohistochemistry to assess the proliferation and survival of cells following complete spinal cord transection using teleost fish.

Fri May 17 00:00:00 EDT 2013

Characterization of Na+ and Ca2+ channels in zebrafish dorsal root ganglion neurons.

PloS one

Won YJ,Ono F,Ikeda SR

A-21271 was used in immunohistochemistry - frozen section to compare electrophysiological events in rats and zebrafish.

Thu Jan 10 00:00:00 EST 2013

Zebrafish Mnx proteins specify one motoneuron subtype and suppress acquisition of interneuron characteristics.

Neural development

Seredick SD,Van Ryswyk L,Hutchinson SA,Eisen JS

A-21271 was used in immunohistochemistry to examine the roles of Mnx family transcription factors in specifying the subtypes of individually identified zebrafish primary motoneurons

Mon Nov 05 00:00:00 EST 2012

Glucagon-like peptides 1 and 2 and vasoactive intestinal peptide are neuroprotective on cultured and mast cell co-cultured rat myenteric neurons.

BMC gastroenterology

Voss U,Sand E,Hellström PM,Ekblad E

A-21271 was used in immunocytochemistry to assess the neuroprotective effects of vasoactive intestinal peptide and glucagon-like peptide and 2.

Sun Apr 01 00:00:00 EDT 2012

Brain selective transgene expression in zebrafish using an NRSE derived motif.

Frontiers in neural circuits

Bergeron SA,Hannan MC,Codore H,Fero K,Li GH,Moak Z,Yokogawa T,Burgess HA

A-21271 was used in immunohistochemistry to study how to restrict transgene expression to the nervous system in zebrafish larvae.

Tue Jan 08 00:00:00 EST 2013

Glucagon-like peptide-1 modulates neurally evoked mucosal chloride secretion in guinea pig small intestine in vitro.

American journal of physiology. Gastrointestinal and liver physiology

Baldassano S,Wang GD,Mulè F,Wood JD

A-21271 was used in Immunohistochemistry to investigate effects of GLP-1.

Wed Feb 01 00:00:00 EST 2012

CD140a identifies a population of highly myelinogenic, migration-competent and efficiently engrafting human oligodendrocyte progenitor cells.

Nature biotechnology

Sim FJ,McClain CR,Schanz SJ,Protack TL,Windrem MS,Goldman SA

A-21271 was used in Immunocytochemistry-immunoflourescence to establish a more efficient means of isolating myelinogenic oligodendrocyte progenitor cells.

Sun Sep 25 00:00:00 EDT 2011

Vertebrate-specific glutaredoxin is essential for brain development.

Proceedings of the National Academy of Sciences of the United States of America

Bräutigam L,Schütte LD,Godoy JR,Prozorovski T,Gellert M,Hauptmann G,Holmgren A,Lillig CH,Berndt C

A-21271 was used in immunohistochemistry to report that embryonic brain development depends on glutaredoxin 2 activity.

Tue Dec 20 00:00:00 EST 2011

Paraneoplastic upbeat nystagmus.

Neurology

Wray SH,Martinez-Hernandez E,Dalmau J,Maheshwari A,Chen A,King S,Bishop Pitman M,Leigh RJ

A-21271 was used in immunohistochemistry to discuss paraneoplastic upbeat nystagmus.

Tue Aug 16 00:00:00 EDT 2011

Regeneration of the adult zebrafish brain from neurogenic radial glia-type progenitors.

Development (Cambridge, England)

Kroehne V,Freudenreich D,Hans S,Kaslin J,Brand M

A-21271 was used in immunohistochemistry to investigate brain regeneration mechanisms in adult zebrafish.

Tue Nov 01 00:00:00 EDT 2011

Defective neuroepithelial cell cohesion affects tangential branchiomotor neuron migration in the zebrafish neural tube.

Development (Cambridge, England)

Stockinger P,Maître JL,Heisenberg CP

A-21271 was used in immunohistochemistry to determine the role of neuroepithelial cells cohesion in facial branchiomotor neuron migration.

Tue Nov 01 00:00:00 EDT 2011

Macroglial plasticity and the origins of reactive astroglia in experimental autoimmune encephalomyelitis.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Guo F,Maeda Y,Ma J,Delgado M,Sohn J,Miers L,Ko EM,Bannerman P,Xu J,Wang Y,Zhou C,Takebayashi H,Pleasure D

A-21271 was used in immunohistochemistry to determine the origin of hypertrophic GFAP(+)/vimentin(+)/nestin(+) "reactive" astroglia.

Wed Aug 17 00:00:00 EDT 2011

Homeodomain interacting protein kinase 2 regulates postnatal development of enteric dopaminergic neurons and glia via BMP signaling.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Chalazonitis A,Tang AA,Shang Y,Pham TD,Hsieh I,Setlik W,Gershon MD,Huang EJ

A-21271 was used in immunohistochemistry to elucidate mechanisms that regulate the maturation of enteric neurons in postnatal life.

Wed Sep 28 00:00:00 EDT 2011

Authentically phosphorylated α-synuclein at Ser129 accelerates neurodegeneration in a rat model of familial Parkinson's disease.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Sato H,Arawaka S,Hara S,Fukushima S,Koga K,Koyama S,Kato T

A-21271 was used in western blot to elucidate the role of Ser129 phosphorylation in α-syn neurotoxicity.

Wed Nov 16 00:00:00 EST 2011

Dopamine D2 receptor activity modulates Akt signaling and alters GABAergic neuron development and motor behavior in zebrafish larvae.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Souza BR,Romano-Silva MA,Tropepe V

A-21271 was used in immunohistochemistry to use a zebrafish model to examine the impact of altered dopamine signaling on brain development and larval motor behavior.

Wed Apr 06 00:00:00 EDT 2011

Paraneoplastic disorders of eye movements.

Annals of the New York Academy of Sciences

Wray SH,Dalmau J,Chen A,King S,Leigh RJ

A-21271 was used in immunohistochemistry to study upbeat nystagmus in a female patient with pancreatic cancer.

Thu Sep 01 00:00:00 EDT 2011

The RNA-binding protein HuR promotes glioma growth and treatment resistance.

Molecular cancer research : MCR

Filippova N,Yang X,Wang Y,Gillespie GY,Langford C,King PH,Wheeler C,Nabors LB

A-21271 was used in western blot to investigate the role of HuR in brain tumor growth.

Sun May 01 00:00:00 EDT 2011

Gastrointestinal neuromuscular pathology in alpers disease.

The American journal of surgical pathology

Kapur RP,Fligner C,Maghsoodi B,Jaffe R

A-21271 was used in immunohistochemistry - paraffin section to examine the gastrointestinal neuromuscular pathology in patients with Alpers disease.

Sun May 01 00:00:00 EDT 2011

GABAergic signalling in a neurogenic niche of the turtle spinal cord.

The Journal of physiology

Reali C,Fernández A,Radmilovich M,Trujillo-Cenóz O,Russo RE

A-21271 was used in immunohistochemistry to study the action of GABA around the central canal of the turtle spinal cord.

Thu Dec 01 00:00:00 EST 2011

Nervous system disruption and concomitant behavioral abnormality in early hatched pufferfish larvae exposed to heavy oil.

Environmental science and pollution research international

Kawaguchi M,Sugahara Y,Watanabe T,Irie K,Ishida M,Kurokawa D,Kitamura S,Takata H,Handoh IC,Nakayama K,Murakami Y

A-21271 was used in immunohistochemistry to clarify the toxicological effects of heavy oil on fish eggs.

Mon Aug 01 00:00:00 EDT 2011

Immunolocalization of aquaporin-4 in the brain, kidney, skeletal muscle, and gastro-intestinal tract of chicken.

Cell and tissue research

Yoshimura K,Sugiura K,Ohmori Y,Aste N,Saito N

A-21271 was used in immunohistochemistry - frozen section to report the distribution of chicken aquaporin-4.

Fri Apr 01 00:00:00 EDT 2011

Calbindin immunoreactivity in the enteric nervous system of larval and adult zebrafish (Danio rerio).

Cell and tissue research

Olsson C

A-21271 was used in immunohistochemistry to study calbindin in the gut of adult and larval zebrafish.

Fri Apr 01 00:00:00 EDT 2011

Postnatal intestinal engraftment of prospectively selected enteric neural crest stem cells in a rat model of Hirschsprung disease.

Neurogastroenterology and motility

Tsai YH,Murakami N,Gariepy CE

A-21271 was used in immunohistochemistry - frozen section to investigate the therapeutic potential of enteric neural crest stem cells in Hirschsprung disease.

Fri Apr 01 00:00:00 EDT 2011

Subnuclear development of the zebrafish habenular nuclei requires ER translocon function.

Developmental biology

Doll CA,Burkart JT,Hope KD,Halpern ME,Gamse JT

A-21271 was used in immunohistochemistry to assess the contribution of sec61al1 in the formation of bilaterally symmetric habenular nuclei.

Thu Dec 01 00:00:00 EST 2011

Neurovascular development in the embryonic zebrafish hindbrain.

Developmental biology

Ulrich F,Ma LH,Baker RG,Torres-Vázquez J

A-21271 was used in immunohistochemistry to investigate the assembly of the cerebral vasculature.

Thu Sep 01 00:00:00 EDT 2011

Aquaporin 1 water channel is expressed on submucosal but not myenteric neurons from the ovine duodenum.

Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft

Arciszewski MB,Stefaniak M,Zacharko-Siembida A,Całka J

A-21271 was used in immunohistochemistry to determine the localization of aquaporin 1 in the sheep duodenum.

Tue Mar 01 00:00:00 EST 2011

Lineage analysis of newly generated neurons in organotypic culture of rat hippocampus.

Neuroscience research

Yokose J,Ishizuka T,Yoshida T,Aoki J,Koyanagi Y,Yawo H

A-21271 was used in immunohistochemistry to determine the origin of new neurons in the hippocampus.

Tue Mar 01 00:00:00 EST 2011

Calbindin-immunoreactive cells in the fish enteric nervous system.

Autonomic neuroscience : basic & clinical

Olsson C

A-21271 was used in immunohistochemistry to examine calbindin immunoreactivity in the enteric nervous system of the teleost shorthorn sculpin

Thu Jan 20 00:00:00 EST 2011

Evidence implicating the Ras pathway in multiple CD28 costimulatory functions in CD4+ T cells.

PloS one

Janardhan SV,Praveen K,Marks R,Gajewski TF

A-21271 was used in western blot to identify pathways that can functionally replace CD28-mediated costimulation in normal T cells.

Fri Feb 03 00:00:00 EST 2012

Sequential generation of olfactory bulb glutamatergic neurons by Neurog2-expressing precursor cells.

Neural development

Winpenny E,Lebel-Potter M,Fernandez ME,Brill MS,Götz M,Guillemot F,Raineteau O

A-21271 was used in immunohistochemistry to study the different subtypes of glutamatergic OB interneurons.

Tue Apr 05 00:00:00 EDT 2011

Corticotropin releasing factor-distribution in rat intestine and role in neuroprotection.

Regulatory peptides

Sand E,Themner-Persson A,Ekblad E

A-21271 was used in immunocytochemistry to study the localization of corticotropin releasing factor in rat small and large intestines and study its role in nerve survival

Mon Jan 17 00:00:00 EST 2011

Increased proportion of nitric oxide synthase immunoreactive neurons in rat ileal myenteric ganglia after severe acute pancreatitis.

BMC gastroenterology

Lin Z,Liu Y,Zheng Q,Hu Q

A-21271 was used in immunohistochemistry to examine the contribution of nitric oxide synthase-immunoreactive neurons to pancreatitis-induced ileus

Wed Nov 23 00:00:00 EST 2011

Dynamic expression of cadherins regulates vocal development in a songbird.

PloS one

Matsunaga E,Suzuki K,Kato S,Kurotani T,Kobayashi K,Okanoya K

A-21271 was used in western blot to elucidate the molecular mechanisms that regulate avian vocal development.

Fri Feb 03 00:00:00 EST 2012

MAZe: a tool for mosaic analysis of gene function in zebrafish.

Nature methods

Collins RT,Linker C,Lewis J

A-21271 was used in immunohistochemistry to create tools to help make inducible knockout zebrafish

Mon Mar 01 00:00:00 EST 2010

Short-chain fatty acids regulate the enteric neurons and control gastrointestinal motility in rats.

Gastroenterology

Soret R,Chevalier J,De Coppet P,Poupeau G,Derkinderen P,Segain JP,Neunlist M

A-21271 was used in Immunohistochemistry-immunofluorescence to investigate the effects of short-chain fatty acids on the enteric nervous system and colonic motility.

Sat May 01 00:00:00 EDT 2010

Differential actions of urocortins on neurons of the myenteric division of the enteric nervous system in guinea pig distal colon.

British journal of pharmacology

Liu S,Ren W,Qu MH,Bishop GA,Wang GD,Wang XY,Xia Y,Wood JD

A-21271 was used in immunohistochemistry to test if urocortins in the enteric nervous system regulate colonic motor behavior

Fri Jan 01 00:00:00 EST 2010

Biogenesis of GPI-anchored proteins is essential for surface expression of sodium channels in zebrafish Rohon-Beard neurons to respond to mechanosensory stimulation.

Development (Cambridge, England)

Nakano Y,Fujita M,Ogino K,Saint-Amant L,Kinoshita T,Oda Y,Hirata H

A-21271 was used in immunohistochemistry to study the contribution of sodium channels to mechanosensory responses in zebrafish

Sat May 01 00:00:00 EDT 2010

Isolation and propagation of enteric neural crest progenitor cells from mouse embryonic stem cells and embryos.

Development (Cambridge, England)

Kawaguchi J,Nichols J,Gierl MS,Faial T,Smith A

A-21271 was used in Immunocytochemistry to investigate the generation, maintenance, and expansion of neural crest progenitors.

Mon Mar 01 00:00:00 EST 2010

Protogenin defines a transition stage during embryonic neurogenesis and prevents precocious neuronal differentiation.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Wong YH,Lu AC,Wang YC,Cheng HC,Chang C,Chen PH,Yu JY,Fann MJ

A-21271 was used in immunocytochemistry to determine the expression and function of protogenin in the developing nervous system

Wed Mar 24 00:00:00 EDT 2010

Embryonic retinal cells and support to mature retinal neurons.

Investigative ophthalmology & visual science

Stanke JJ,Fischer AJ

A-21271 was used in immunohistochemistry to test if transplanted embryonic retinal cells from various stages of development influence the survival of mature ganglion cells

Thu Apr 01 00:00:00 EDT 2010

Glial cells revealed by GFAP immunoreactivity in fish gut.

Cell and tissue research

Hagström C,Olsson C

A-21271 was used in immunohistochemistry - frozen section to determine the localization of glial fibrillary acidic protein immunoreactivity in adult and developing fish

Thu Jul 01 00:00:00 EDT 2010

Inhibitory neuromuscular transmission to ileal longitudinal muscle predominates in neonatal guinea pigs.

Neurogastroenterology and motility

Patel BA,Dai X,Burda JE,Zhao H,Swain GM,Galligan JJ,Bian X

A-21271 was used in immunohistochemistry to discuss neurotransmission to the longitudinal muscle in neonatal and adult guinea pig ileum

Sun Aug 01 00:00:00 EDT 2010

Glial fibrillary acidic protein-expressing neural progenitors give rise to immature neurons via early intermediate progenitors expressing both glial fibrillary acidic protein and neuronal markers in the adult hippocampus.

Neuroscience

Liu Y,Namba T,Liu J,Suzuki R,Shioda S,Seki T

A-21271 was used in immunohistochemistry - free floating to investigate how astrocyte-like progenitors differentiate into neuron-committed progenitors

Wed Mar 10 00:00:00 EST 2010

Inhibition of caspase-3-mediated apoptosis improves spinal cord repair in a regeneration-competent vertebrate system.

Neuroscience

Sîrbulescu RF,Zupanc GK

A-21271 was used in immunohistochemistry to use teleost fish to test if inhibition of apoptosis after injury enhances spinal cord regeneration

Wed Dec 01 00:00:00 EST 2010

Microvillous cells expressing IP3 receptor type 3 in the olfactory epithelium of mice.

The European journal of neuroscience

Hegg CC,Jia C,Chick WS,Restrepo D,Hansen A

A-21271 was used in immunohistochemistry - frozen section to characterize cells expressing IP3 receptor type 3 in the olfactory epithelium

Mon Nov 01 00:00:00 EDT 2010

Distinct requirements for Ascl1 in subpopulations of midbrain GABAergic neurons.

Developmental biology

Peltopuro P,Kala K,Partanen J

A-21271 was used in immunohistochemistry - paraffin section to study the distinct involvement of Asc11 in the development of different midbrain GABAergic neurone sub-populations

Thu Jul 01 00:00:00 EDT 2010

Expression of neuronal markers, synaptic proteins, and glutamine synthetase in the control and regenerating lizard visual system.

The Journal of comparative neurology

Romero-Alemán MM,Monzón-Mayor M,Santos E,Yanes C

A-21271 was used in immunohistochemistry and western blot to study the expression of neuronal markers, synaptic proteins, and glutamine synthetase during visual regeneration in lizards.

Fri Oct 01 00:00:00 EDT 2010

Neurochemical coding of enteric neurons in adult and embryonic zebrafish (Danio rerio).

The Journal of comparative neurology

Uyttebroek L,Shepherd IT,Harrisson F,Hubens G,Blust R,Timmermans JP,Van Nassauw L

A-21271 was used in immunohistochemistry to investigate the neurochemical coding of enteric neurons in zebrafish

Mon Nov 01 00:00:00 EDT 2010

Area-specific migration and recruitment of new neurons in the adult songbird brain.

The Journal of comparative neurology

Vellema M,van der Linden A,Gahr M

A-21271 was used in immunohistochemistry to study neuronal migration and recruitment in the adult songbird brain

Sat May 01 00:00:00 EDT 2010

Identification of cerebellin2 in chick and its preferential expression by subsets of developing sensory neurons and their targets in the dorsal horn.

The Journal of comparative neurology

Yang M,Cagle MC,Honig MG

A-21271 was used in immunohistochemistry to identify cerebellin2 in chick and study its expression pattern

Thu Jul 15 00:00:00 EDT 2010

Early acquisition of neural crest competence during hESCs neuralization.

PloS one

Curchoe CL,Maurer J,McKeown SJ,Cattarossi G,Cimadamore F,Nilbratt M,Snyder EY,Bronner-Fraser M,Terskikh AV

A-21271 was used in immunocytochemistry and immunohistochemistry to discuss neural crest stem cells

Tue Nov 09 00:00:00 EST 2010

Abnormal nuclear pore formation triggers apoptosis in the intestinal epithelium of elys-deficient zebrafish.

Gastroenterology

de Jong-Curtain TA,Parslow AC,Trotter AJ,Hall NE,Verkade H,Tabone T,Christie EL,Crowhurst MO,Layton JE,Shepherd IT,Nixon SJ,Parton RG,Zon LI,Stainier DY,Lieschke GJ,Heath JK

A-21271 was used in immunohistochemistry to identify the gene impacted in the "flotte lotte" zebrafish mutant

Sun Mar 01 00:00:00 EST 2009

Cellular glutathione peroxidase in human brain: cellular distribution, and its potential role in the degradation of Lewy bodies in Parkinson's disease and dementia with Lewy bodies.

Acta neuropathologica

Power JH,Blumbergs PC

A-21271 was used in immunohistochemistry to determine the expression of glutathione peroxidase in control, Parkinson's disease, and dementia with Lewy bodies tissues

Thu Jan 01 00:00:00 EST 2009

Complex I deficiency and dopaminergic neuronal cell loss in parkin-deficient zebrafish (Danio rerio).

Brain : a journal of neurology

Flinn L,Mortiboys H,Volkmann K,Köster RW,Ingham PW,Bandmann O

A-21271 was used in immunocytochemistry to develop and characterize a zebrafish model for Parkin deficiency

Mon Jun 01 00:00:00 EDT 2009

Dose optimization for long-term rAAV-mediated RNA interference in the nigrostriatal projection neurons.

Molecular therapy : the journal of the American Society of Gene Therapy

Ulusoy A,Sahin G,Björklund T,Aebischer P,Kirik D

A-21271 was used in Immunohistochemistry to demonstrate that long-term, efficient knockdown of tyrosine hydroxylase in the absence of any apparent nonspecific toxicity can be obtained using an rAAV-mediated shRNA delivery.

Tue Sep 01 00:00:00 EDT 2009

Mitogen-activated protein kinase-signaling stimulates Müller glia to proliferate in acutely damaged chicken retina.

Glia

Fischer AJ,Scott MA,Tuten W

A-21271 was used in immunohistochemistry - frozen section to determine the roles of the mitogen-activated protein kinase pathway in regulating the activity of Muller glia in the chicken retina

Thu Jan 15 00:00:00 EST 2009

Morphogenesis and cytodifferentiation of the avian retinal pigmented epithelium require downregulation of Group B1 Sox genes.

Development (Cambridge, England)

Ishii Y,Weinberg K,Oda-Ishii I,Coughlin L,Mikawa T

A-21271 was used in immunohistochemistry to suggest that retinal pigment epithelium morphogenesis and cytodifferentiation requires SoxB1 downregulation and an absence of FGF-like signal

Sat Aug 01 00:00:00 EDT 2009

Gata2 is a tissue-specific post-mitotic selector gene for midbrain GABAergic neurons.

Development (Cambridge, England)

Kala K,Haugas M,Lilleväli K,Guimera J,Wurst W,Salminen M,Partanen J

A-21271 was used in immunohistochemistry - paraffin section to study the role of the Gata2 transcription factor in midbrain GABAergic neurons

Thu Jan 01 00:00:00 EST 2009

Mast cells reduce survival of myenteric neurons in culture.

Neuropharmacology

Sand E,Themner-Persson A,Ekblad E

A-21271 was used in immunocytochemistry to examine the impact of mast cells on neuronal survival and plasticity of myenteric neurons

Sun Feb 01 00:00:00 EST 2009

Brain-endocrine interactions: a microvascular route in the mediobasal hypothalamus.

Endocrinology

Ciofi P,Garret M,Lapirot O,Lafon P,Loyens A,Prévot V,Levine JE

A-21271 was used in immunohistochemistry to study the brain-endocrine interactions in the mediobasal hypothalamus.

Tue Dec 01 00:00:00 EST 2009

Development of microglia in the chick embryo spinal cord: implications in the regulation of motoneuronal survival and death.

Journal of neuroscience research

Calderó J,Brunet N,Ciutat D,Hereu M,Esquerda JE

A-21271 was used in immunocytochemistry to study the development of microglia in the spinal cord and characterize their changes in response to naturally occurring and pathological death of motoneurons

Sat Aug 15 00:00:00 EDT 2009

Quantitative evaluation of myenteric ganglion cells in normal human left colon: implications for histopathological analysis.

Cell and tissue research

Ippolito C,Segnani C,De Giorgio R,Blandizzi C,Mattii L,Castagna M,Moscato S,Dolfi A,Bernardini N

A-21271 was used in immunohistochemistry - paraffin section to find a method to detect and count myenteric neurons and glial cells in paraffin sections of human colon

Fri May 01 00:00:00 EDT 2009

Fall in density, but not number of myenteric neurons and circular muscle nerve fibres in guinea-pig colon with ageing.

Neurogastroenterology and motility

Peck CJ,Samsuria SD,Harrington AM,King SK,Hutson JM,Southwell BR

A-21271 was used in immunohistochemistry to examine age-associated changes in the guinea-pig ileum

Thu Oct 01 00:00:00 EDT 2009

Analysis of gastrointestinal physiology using a novel intestinal transit assay in zebrafish.

Neurogastroenterology and motility

Field HA,Kelley KA,Martell L,Goldstein AM,Serluca FC

A-21271 was used in immunocytochemistry to develop a method for visualizing intestinal transit in larval zebrafish

Sun Mar 01 00:00:00 EST 2009

Generation, long-term persistence, and neuronal differentiation of cells with nuclear aberrations in the adult zebrafish brain.

Neuroscience

Zupanc GK,Wellbrock UM,Sîrbulescu RF,Rajendran RS

A-21271 was used in immunohistochemistry to characterize nuclear aberrations present in zebrafish brains

Fri Apr 10 00:00:00 EDT 2009

Effects of estradiol on incorporation of new cells in the developing zebra finch song system: potential relationship to expression of ribosomal proteins L17 and L37.

Developmental neurobiology

Tang YP,Wade J

A-21271 was used in immunohistochemistry to compare estrogen and ribosomal protein expression in juvenile male and female zebra finches

Mon Jun 01 00:00:00 EDT 2009

Triple fluorescence labelling of neuronal, glial and vascular markers revealing pathological alterations in various animal models.

Journal of chemical neuroanatomy

Härtig W,Reichenbach A,Voigt C,Boltze J,Bulavina L,Schuhmann MU,Seeger J,Schusser GF,Freytag C,Grosche J

A-21271 was used in immunohistochemistry to develop a method for the carbocyanine triple fluorescence labelling of neuronal, vascular, and glial markers and use this technique to study a mouse model of Alzheimer's disease

Sun Mar 01 00:00:00 EST 2009

Birth of ophthalmic trigeminal neurons initiates early in the placodal ectoderm.

The Journal of comparative neurology

McCabe KL,Sechrist JW,Bronner-Fraser M

A-21271 was used in immunohistochemistry to investigate the development of ophthalmic trigeminal neurons.

Sun May 10 00:00:00 EDT 2009

Excitotoxic motoneuron degeneration induced by glutamate receptor agonists and mitochondrial toxins in organotypic cultures of chick embryo spinal cord.

The Journal of comparative neurology

Brunet N,Tarabal O,Esquerda JE,Calderó J

A-21271 was used in immunohistochemistry to investigate the excitotoxicity of glutamate receptor agonists and mitochondrial toxins in organotypic cultures of chick embryo spinal cord.

Thu Oct 01 00:00:00 EDT 2009

Use of phospholipase A2 for antigen retrieval in zebrafish whole-mount immunohistochemistry.

Zebrafish

Akhtar T,Li J,Olden T,Wallace KN

A-21271 was used in immunohistochemistry - paraffin section to discuss methods for antigen retrieval

Tue Sep 01 00:00:00 EDT 2009

Identification of Wnt-responsive cells in the zebrafish hypothalamus.

Zebrafish

Wang X,Lee JE,Dorsky RI

A-21271 was used in immunohistochemistry to elucidate the exact roles of canonical Wnt signaling in neurogenesis

Sun Mar 01 00:00:00 EST 2009

Immunodetection of cocaine- and amphetamine-regulated transcript in the rumen, reticulum, omasum and abomasum of the sheep.

Anatomia, histologia, embryologia

Arciszewski MB,Barabasz S,Skobowiat C,Maksymowicz W,Majewski M

A-21271 was used in immunohistochemistry - frozen section to determine the distribution patterns of cocaine- and amphetamine-regulated transcript-immunoreactive nerve fibers and enteric neurons present in the rumen, reticulum, omasum, and abomasum of the

Sun Feb 01 00:00:00 EST 2009

Myenteric neurons of the ileum that express somatostatin are a target of prion neuroinvasion in an alimentary model of sheep scrapie.

Acta neuropathologica

Schneider DA,Yan H,Fry LM,Alverson J,White SN,O'Rourke KI

A-21271 was used in immunohistochemistry - paraffin section to study enteric neuroinvasion by scrapie prions

Sun Jun 01 00:00:00 EDT 2008

Gsk3beta/PKA and Gli1 regulate the maintenance of neural progenitors at the midbrain-hindbrain boundary in concert with E(Spl) factor activity.

Development (Cambridge, England)

Ninkovic J,Stigloher C,Lillesaar C,Bally-Cuif L

A-21271 was used in Immunohistochemistry to suggest a model in which the modulation of E(Spl) and Gsk3beta/PKA activities by Gli1 underlies the dynamic properties of intervening zone maintenance and recruitment.

Mon Sep 01 00:00:00 EDT 2008

Signals from the neural crest regulate beta-cell mass in the pancreas.

Development (Cambridge, England)

Nekrep N,Wang J,Miyatsuka T,German MS

A-21271 was used in Immunohistochemistry-immunofluorescence to identify the feedback mechanism by which the ectoderm derived neural crest influences the development of the endoderm derived pancreatic islet cells.

Sun Jun 01 00:00:00 EDT 2008

Testosterone-induced matrix metalloproteinase activation is a checkpoint for neuronal addition to the adult songbird brain.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Kim DH,Lilliehook C,Roides B,Chen Z,Chang M,Mobashery S,Goldman SA

A-21271 was used in Immunohistochemistry to investigate the role of the gelatinases in neuronal addition to the HVC of adult female canaries.

Wed Jan 02 00:00:00 EST 2008

Zebrafish dorsal root ganglia neural precursor cells adopt a glial fate in the absence of neurogenin1.

The Journal of neuroscience : the official journal of the Society for Neuroscience

McGraw HF,Nechiporuk A,Raible DW

A-21271 was used in immunohistochemistry to demonstrate that the neural crest population that gives rise to dorsal root ganglion neurons becomes fate restricted to a neuronal/glial precursor before the onset of neurog1 function using transgenic zebrafish

Wed Nov 19 00:00:00 EST 2008

Activity-dependent expression of ELAV/Hu RBPs and neuronal mRNAs in seizure and cocaine brain.

Journal of neurochemistry

Tiruchinapalli DM,Caron MG,Keene JD

A-21271 was used in immunohistochemistry - frozen section and western blot to determine the localization of HuR and HuD RNA-binding proteins after seizure or cocaine treatment.

Mon Dec 01 00:00:00 EST 2008

Smooth muscle NOS, colocalized with caveolin-1, modulates contraction in mouse small intestine.

Journal of cellular and molecular medicine

El-Yazbi AF,Cho WJ,Cena J,Schulz R,Daniel EE

A-21271 was used in immunohistochemistry - frozen section to investigate the functions of nNOS in mouse small intestinal smooth muscle

Fri Aug 01 00:00:00 EDT 2008

Sex differences in serotonergic but not gamma-aminobutyric acidergic (GABA) projections to the rat ventromedial nucleus of the hypothalamus.

Endocrinology

Patisaul HB,Fortino AE,Polston EK

A-21271 was used in immunohistochemistry to study sex differences that contribute to development of lordosis.

Tue Jan 01 00:00:00 EST 2008

Leptin-dependent STAT3 phosphorylation in postnatal mouse hypothalamus.

Brain research

Frontini A,Bertolotti P,Tonello C,Valerio A,Nisoli E,Cinti S,Giordano A

A-21271 was used in immunohistochemistry to investigate the timing of maturation of the leptin signal transduction system

Wed Jun 18 00:00:00 EDT 2008

A novel role for zebrafish zic2a during forebrain development.

Developmental biology

Sanek NA,Grinblat Y

A-21271 was used in immunohistochemistry to identify Zic2a as a novel regulator of prethalamic development in zebrafish

Thu May 01 00:00:00 EDT 2008

Endoderm-derived Sonic hedgehog and mesoderm Hand2 expression are required for enteric nervous system development in zebrafish.

Developmental biology

Reichenbach B,Delalande JM,Kolmogorova E,Prier A,Nguyen T,Smith CM,Holzschuh J,Shepherd IT

A-21271 was used in Immunohistochemistry to show that endoderm and HH signaling, but not hand2, regulate gdnf expression in the intestine, highlighting a central role of endoderm and SHH in patterning the intestine and the ENS.

Sun Jun 01 00:00:00 EDT 2008

Intrinsic neuronal control of the pyloric sphincter of the lamb.

Journal of chemical neuroanatomy

Mazzuoli G,Lucherini MC,Russo D,Clavenzani P,Chiocchetti R

A-21271 was used in immunohistochemistry to examine the enteric nervous system innervating the pyloric sphincter of the lamb abomasum

Wed Oct 01 00:00:00 EDT 2008

Distribution of calretinin during development of the olfactory system in the brown trout, Salmo trutta fario: Comparison with other immunohistochemical markers.

Journal of chemical neuroanatomy

Castro A,Becerra M,Anadón R,Manso MJ

A-21271 was used in immunohistochemistry - paraffin section to study the appearance and distribution of calretinin in the olfactory system of developing and adult brown trout

Tue Jul 01 00:00:00 EDT 2008

Fgf signaling in the zebrafish adult brain: association of Fgf activity with ventricular zones but not cell proliferation.

The Journal of comparative neurology

Topp S,Stigloher C,Komisarczuk AZ,Adolf B,Becker TS,Bally-Cuif L

A-21271 was used in immunohistochemistry to investigate the role of FGF in stem cell maintenance and neurogenesis in zebrafish

Wed Oct 01 00:00:00 EDT 2008

Quantitative assessment of glial cells in the human and guinea pig enteric nervous system with an anti-Sox8/9/10 antibody.

The Journal of comparative neurology

Hoff S,Zeller F,von Weyhern CW,Wegner M,Schemann M,Michel K,Rühl A

A-21271 was used in immunohistochemistry to quantitate glial cells in the human and guinea pig enteric nervous system.

Fri Aug 01 00:00:00 EDT 2008

Differential expression of canonical (classical) transient receptor potential channels in guinea pig enteric nervous system.

The Journal of comparative neurology

Liu S,Qu MH,Ren W,Hu HZ,Gao N,Wang GD,Wang XY,Fei G,Zuo F,Xia Y,Wood JD

A-21271 was used in immunohistochemistry to study canonical transient receptor potential channels in guinea pig enteric nervous system.

Sat Dec 20 00:00:00 EST 2008

Developmental and spatial expression pattern of alpha-taxilin in the rat central nervous system.

The Journal of comparative neurology

Sakakibara S,Nakadate K,Tanaka-Nakadate S,Yoshida K,Nogami S,Shirataki H,Ueda S

A-21271 was used in immunohistochemistry to localize alpha-taxilin in the rat central nervous system.

Sat Nov 01 00:00:00 EDT 2008

Fate mapping Nkx2.1-lineage cells in the mouse telencephalon.

The Journal of comparative neurology

Xu Q,Tam M,Anderson SA

A-21271 was used in immunohistochemistry to study the contribution of Nkx2.1 lineages to neurons in the mature telencephalon

Tue Jan 01 00:00:00 EST 2008

Development of enteric and vagal innervation of the zebrafish (Danio rerio) gut.

The Journal of comparative neurology

Olsson C,Holmberg A,Holmgren S

A-21271 was used in immunohistochemistry to study the neuronal development in the zebrafish gut.

Tue Jun 10 00:00:00 EDT 2008

Notch-regulated oligodendrocyte specification from radial glia in the spinal cord of zebrafish embryos.

Developmental dynamics : an official publication of the American Association of Anatomists

Kim H,Shin J,Kim S,Poling J,Park HC,Appel B

A-21271 was used in Immunocytochemistry to investigate formation of radial glia in the spinal cord of zebrafish and the role of Notch signalling in their maintenance and specification.

Fri Aug 01 00:00:00 EDT 2008

Nest of origin predicts adult neuron addition rates in the vocal control system of the zebra finch.

Brain, behavior and evolution

Hurley P,Pytte C,Kirn JR

A-21271 was used in Immunohistochemistry to explore the extent to which nest of origin predicts rates of HVC neuron addition in adult male zebra finches.

Thu Jul 17 00:00:00 EDT 2008

Disruption of AP1S1, causing a novel neurocutaneous syndrome, perturbs development of the skin and spinal cord.

PLoS genetics

Montpetit A,Côté S,Brustein E,Drouin CA,Lapointe L,Boudreau M,Meloche C,Drouin R,Hudson TJ,Drapeau P,Cossette P

A-21271 was used in immunohistochemistry to describe the first mutation in the human AP1S1 gene

Mon Dec 01 00:00:00 EST 2008

Genesis of neuronal and glial progenitors in the cerebellar cortex of peripuberal and adult rabbits.

PloS one

Ponti G,Peretto P,Bonfanti L

A-21271 was used in Immunohistochemistry to reveal that adult cerebellar neurogenesis can exist in some mammals, and therefore provide a suitable model for studying adult nervous tissue permissiveness.

Wed Jun 04 00:00:00 EDT 2008

Vasoactive intestinal peptide rescues cultured rat myenteric neurons from lipopolysaccharide induced cell death.

Regulatory peptides

Arciszewski MB,Sand E,Ekblad E

A-21271 was used in immunocytochemistry to assess the effects of lipopolysaccharide on enteric neurons

Thu Feb 07 00:00:00 EST 2008

Regional variation in the neurochemical coding of the myenteric plexus of the human colon and changes in patients with slow transit constipation.

Neurogastroenterology and motility

Wattchow D,Brookes S,Murphy E,Carbone S,de Fontgalland D,Costa M

A-21271 was used in Immunohistochemistry to compare density of innervation between regions and between normal patients and those undergoing resection for severe constipation.

Mon Dec 01 00:00:00 EST 2008

Demonstration of functional neuronal beta3-adrenoceptors within the enteric nervous system.

Gastroenterology

Cellek S,Thangiah R,Bassil AK,Campbell CA,Gray KM,Stretton JL,Lalude O,Vivekanandan S,Wheeldon A,Winchester WJ,Sanger GJ,Schemann M,Lee K

A-21271 was used in Immunofluorescence in immunohistochemistry on frozen tissues to investigate the expression of beta(3)-AR in human enteric nervous system and its role in motility and visceral algesia.

Sun Jul 01 00:00:00 EDT 2007

Mitotic spindle orientation distinguishes stem cell and terminal modes of neuron production in the early spinal cord.

Development (Cambridge, England)

Wilcock AC,Swedlow JR,Storey KG

A-21271 was used in Immunocytochemistry to support a model in which cleavage plane orientation/mitotic spindle position does not assign neuron-generating ability.

Tue May 01 00:00:00 EDT 2007

Postnatal generation of neurons in the ventrobasal nucleus of the rat thalamus.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Mooney SM,Miller MW

A-21271 was used in Immunohistochemistry to examine whether the development of the trigeminal system can proceed via a nonhierarchical mechanism in the rat thalamus.

Wed May 09 00:00:00 EDT 2007

Cross talk between notch and growth factor/cytokine signaling pathways in neural stem cells.

Molecular and cellular biology

Nagao M,Sugimori M,Nakafuku M

A-21271 was used in immunocytochemistry to study Notch signaling in neural stem cells

Fri Jun 01 00:00:00 EDT 2007

Quantification of subclasses of human colonic myenteric neurons by immunoreactivity to Hu, choline acetyltransferase and nitric oxide synthase.

Neurogastroenterology and motility

Murphy EM,Defontgalland D,Costa M,Brookes SJ,Wattchow DA

A-21271 was used in immunohistochemistry to characterize myenteric neurons

Thu Feb 01 00:00:00 EST 2007

Characterization of CaMKII-expressing neurons within a striatal region implicated in avian vocal learning.

Brain research

Hein AM,Sridharan A,Nordeen KW,Nordeen EJ

A-21271 was used in immunohistochemistry to study implication in avian vocal learning by characterizing CaMKII-expressing neurons within a striatal region

Mon Jun 25 00:00:00 EDT 2007

TTX-sensitive and TTX-insensitive control of spontaneous gut motility in the developing zebrafish (Danio rerio) larvae.

The Journal of experimental biology

Holmberg A,Olsson C,Hennig GW

A-21271 was used in immunohistochemistry to analyze the roles of intrinsic and extrinsic innervation for initiating and propagating the spontaneous contractions in the developing zebrafish gut

Thu Mar 01 00:00:00 EST 2007

Purinergic signaling regulates neural progenitor cell expansion and neurogenesis.

Developmental biology

Lin JH,Takano T,Arcuino G,Wang X,Hu F,Darzynkiewicz Z,Nunes M,Goldman SA,Nedergaard M

A-21271 was used in Immunocytochemistry to suggest progenitor cell-derived neurogenesis is thus associated with regions of both active purinergic signaling and modulation thereof.

Thu Feb 01 00:00:00 EST 2007

Identification of aromatase-positive radial glial cells as progenitor cells in the ventricular layer of the forebrain in zebrafish.

The Journal of comparative neurology

Pellegrini E,Mouriec K,Anglade I,Menuet A,Le Page Y,Gueguen MM,Marmignon MH,Brion F,Pakdel F,Kah O

A-21271 was used in immunohistochemistry to identify progenitor cells in the ventricular layer of the zebrafish forebrain.

Thu Mar 01 00:00:00 EST 2007

Cytological organization of the central gelatinosa in the turtle spinal cord.

The Journal of comparative neurology

Trujillo-Cenóz O,Fernández A,Radmilovich M,Reali C,Russo RE

A-21271 was used in immunohistochemistry to investigate the central gelatinosa in the turtle spinal cord

Thu May 10 00:00:00 EDT 2007

FnTm2, a novel brain-specific transcript, is dynamically expressed in the song learning circuit of the zebra finch.

The Journal of comparative neurology

Agate RJ,Hertel M,Nottebohm F

A-21271 was used in immunohistochemistry to study the role of FnTm2 (Phantom 2) in learned song.

Mon Sep 10 00:00:00 EDT 2007

Dynamic expression of the basic helix-loop-helix transcription factor neuroD in the rod and cone photoreceptor lineages in the retina of the embryonic and larval zebrafish.

The Journal of comparative neurology

Ochocinska MJ,Hitchcock PF

A-21271 was used in immunocytochemistry to study the role of the basic helix-loop-helix transcription factor neuroD during the development of rod and cone photoreceptors.

Thu Mar 01 00:00:00 EST 2007

Na(v)1.7 and Na(v)1.3 are the only tetrodotoxin-sensitive sodium channels expressed by the adult guinea pig enteric nervous system.

The Journal of comparative neurology

Sage D,Salin P,Alcaraz G,Castets F,Giraud P,Crest M,Mazet B,Clerc N

A-21271 was used in immunohistochemistry to determine the localization of the Na(v)1.7 alpha subunit in the guinea pig myenteric ganglia.

Mon Oct 01 00:00:00 EDT 2007

Morphology and neurochemistry of descending and ascending myenteric plexus neurons of sheep ileum.

Anatomical record (Hoboken, N.J. : 2007)

Mazzuoli G,Mazzoni M,Albanese V,Clavenzani P,Lalatta-Costerbosa G,Lucchi ML,Furness JB,Chiocchetti R

A-21271 was used in immunohistochemistry to characterize myenteric plexus neurons of the sheep ileum

Sat Dec 01 00:00:00 EST 2007

Survival and neurotransmitter plasticity in cultured rat colonic myenteric neurons.

Regulatory peptides

Kristensson E,Themner-Persson A,Ekblad E

A-21271 was used in immunohistochemistry - frozen section to count the rat colonic myenteric neuronal cells that express calcitonin gene-related peptide, galanin, neuropeptide Y, somatostatin, vasoactive intestinal peptide, and nitric oxide synthase

Thu May 03 00:00:00 EDT 2007

Regeneration of neural crest derivatives in the Xenopus tadpole tail.

BMC developmental biology

Lin G,Chen Y,Slack JM

A-21271 was used in immunohistochemistry - paraffin section to study the regeneration of the neural crest derivatives in the Xenopus tadpole tail

Thu May 24 00:00:00 EDT 2007

GLP-2 receptor localizes to enteric neurons and endocrine cells expressing vasoactive peptides and mediates increased blood flow.

Gastroenterology

Guan X,Karpen HE,Stephens J,Bukowski JT,Niu S,Zhang G,Stoll B,Finegold MJ,Holst JJ,Hadsell D,Nichols BL,Burrin DG

A-21271 was used in Immunohistochemistry to establish cellular localisation of glucagon-like peptide-2 (GLP-2) receptor and functional connection to vascular action of GLP-2 in the gut.

Sun Jan 01 00:00:00 EST 2006

Efficient generation of retinal progenitor cells from human embryonic stem cells.

Proceedings of the National Academy of Sciences of the United States of America

Lamba DA,Karl MO,Ware CB,Reh TA

A-21271 was used in immunocytochemistry to determine how human embryonic stem cells are efficiently generated from retinal progenitor cells

Tue Aug 22 00:00:00 EDT 2006

Oligodendrocytes are a major target of the toxicity of spongiogenic murine retroviruses.

The American journal of pathology

Clase AC,Dimcheff DE,Favara C,Dorward D,McAtee FJ,Parrie LE,Ron D,Portis JL

A-21271 was used in immunohistochemistry - paraffin section to identify the cells infected by FrCasE and Moloney MLV-ts1 viruses

Fri Sep 01 00:00:00 EDT 2006

Platelet-activating factor in the enteric nervous system of the guinea pig small intestine.

American journal of physiology. Gastrointestinal and liver physiology

Wang GD,Wang XY,Hu HZ,Fang XC,Liu S,Gao N,Xia Y

A-21271 was used in Immunohistochemistry-immunofluorescence to study the action of platelet-activating factor (PAF) and the expression of PAF receptor in the enteric nervous system.

Wed Nov 01 00:00:00 EST 2006

Extrinsic and intrinsic sources of calcitonin gene-related peptide immunoreactivity in the lamb ileum: a morphometric and neurochemical investigation.

Cell and tissue research

Chiocchetti R,Grandis A,Bombardi C,Lucchi ML,Dal Lago DT,Bortolami R,Furness JB

A-21271 was used in immunohistochemistry - frozen section to examine the extrinsic origins of calcitonin gene-related peptide immunoreactive nerve fibers in the sheep ileum

Wed Feb 01 00:00:00 EST 2006

Formation of the avian nucleus magnocellularis from the auditory anlage.

The Journal of comparative neurology

Hendricks SJ,Rubel EW,Nishi R

A-21271 was used in immunohistochemistry to study the development of avian auditory system

Sun Oct 01 00:00:00 EDT 2006

Distribution and chemical coding of corticotropin-releasing factor-immunoreactive neurons in the guinea pig enteric nervous system.

The Journal of comparative neurology

Liu S,Gao N,Hu HZ,Wang X,Wang GD,Fang X,Gao X,Xia Y,Wood JD

A-21271 was used in immunohistochemistry to localize corticotropin-releasing factor-immunoreactive neurons in the guinea pig enteric nervous system.

Sun Jan 01 00:00:00 EST 2006

Comparison of extrinsic efferent innervation of guinea pig distal colon and rectum.

The Journal of comparative neurology

Olsson C,Chen BN,Jones S,Chataway TK,Costa M,Brookes SJ

A-21271 was used in western blot to compare the extrinsic efferent innervation of the distal colon and rectum of guinea pigs.

Tue Jun 20 00:00:00 EDT 2006

Mitral cells in the olfactory bulb of adult zebrafish (Danio rerio): morphology and distribution.

The Journal of comparative neurology

Fuller CL,Yettaw HK,Byrd CA

A-21271 was used in immunohistochemistry to identify mitral cells in the olfactory bulb of adult zebrafish

Fri Nov 10 00:00:00 EST 2006

Morphology of VIP/nNOS-immunoreactive myenteric neurons in the human gut.

Histochemistry and cell biology

Brehmer A,Schrödl F,Neuhuber W

A-21271 was used in immunohistochemistry to characterized human myenteric neurons co-immunoreactive for neuronal nitric oxide synthase and vasoactive intestinal peptide

Mon May 01 00:00:00 EDT 2006

Investigation of general and cytoskeletal markers to estimate numbers and proportions of neurons in the human intestine.

Histology and histopathology

Ganns D,Schrödl F,Neuhuber W,Brehmer A

A-21271 was used in immunohistochemistry to compare panneuronal markers in the enteric nervous system

Sun Jan 01 00:00:00 EST 2006

The use of embryonic stem cells to study hedgehog signaling.

Methods in molecular biology (Clifton, N.J.)

Becker S,Grabel L

A-21271 was used in immunocytochemistry to study the role of Hedgehog signaling in the differentiation of the neurectoderm and vascular cell types

Fri Aug 25 00:00:00 EDT 2006

Inhibition of neurogenesis at the zebrafish midbrain-hindbrain boundary by the combined and dose-dependent activity of a new hairy/E(spl) gene pair.

Development (Cambridge, England)

Ninkovic J,Tallafuss A,Leucht C,Topczewski J,Tannhäuser B,Solnica-Krezel L,Bally-Cuif L

A-21271 was used in immunohistochemistry to elucidate the molecular bases for lateral intervening zone formation

Sat Jan 01 00:00:00 EST 2005

Nogo-A interacts with the Nogo-66 receptor through multiple sites to create an isoform-selective subnanomolar agonist.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Hu F,Liu BP,Budel S,Liao J,Chin J,Fournier A,Strittmatter SM

A-21271 was used in immunocytochemistry to define a novel Nogo-A-specific domain in Amino-Nogo that binds the Nogo-66 receptor

Wed Jun 01 00:00:00 EDT 2005

In vivo neurogenesis in the dorsal vagal complex of the adult rat brainstem.

Neuroscience

Bauer S,Hay M,Amilhon B,Jean A,Moyse E

A-21271 was used in immunohistochemistry - frozen section to determine the occurrence of neurogenesis in the dorsal vagal complex of adult rats

Tue Mar 22 00:00:00 EST 2005

Lipopolysaccharide induces cell death in cultured porcine myenteric neurons.

Digestive diseases and sciences

Arciszewski M,Pierzynowski S,Ekblad E

A-21271 was used in immunohistochemistry - frozen section to study the effects of LPS on the survival and neurotransmitter expression of cultured porcine myenteric neurons

Thu Sep 01 00:00:00 EDT 2005

Sonic hedgehog and retinoic acid are not sufficient to induce motoneuron generation in the avian caudal neural tube.

Developmental biology

Afonso ND,Catala M

A-21271 was used in immunohistochemistry to study the development of the caudal neural tube

Tue Mar 15 00:00:00 EST 2005

Functional expression of the peptide transporter PEPT2 in the mammalian enteric nervous system.

The Journal of comparative neurology

Rühl A,Hoppe S,Frey I,Daniel H,Schemann M

A-21271 was used in immunohistochemistry to study PEPT2 in the gastrointestinal tract.

Mon Sep 12 00:00:00 EDT 2005

Distribution and fate of cocaine- and amphetamine-regulated transcript peptide (CARTp)-expressing cells in rat urinary bladder: a developmental study.

The Journal of comparative neurology

Zvarova K,Vizzard MA

A-21271 was used in immunohistochemistry to assess the distribution and fate of cocaine- and amphetamine-regulated transcript peptide-immunoreactive structures in the neonatal and adult rat urinary bladder.

Mon Sep 05 00:00:00 EDT 2005

Sox10 overexpression induces neural crest-like cells from all dorsoventral levels of the neural tube but inhibits differentiation.

Developmental dynamics : an official publication of the American Association of Anatomists

McKeown SJ,Lee VM,Bronner-Fraser M,Newgreen DF,Farlie PG

A-21271 was used in Immunohistochemistry-immunofluorescence to examine the roles of SoxE genes in late neural crest migration and differentiation.

Wed Jun 01 00:00:00 EDT 2005

Morphology of enkephalin-immunoreactive myenteric neurons in the human gut.

Histochemistry and cell biology

Brehmer A,Lindig TM,Schrödl F,Neuhuber W,Ditterich D,Rexer M,Rupprecht H

A-21271 was used in immunohistochemistry to characterize leu-enkephalin positive neurons

Tue Feb 01 00:00:00 EST 2005

Effects of total parenteral nutrition on rat enteric nervous system, intestinal morphology, and motility.

The Journal of surgical research

Ekelund M,Ekelund M,Qader SS,Hallén M,Ekblad E

A-21271 was used in immunohistochemistry - frozen section to examine the enteric nervous system and intestinal mobility of rats that received total parenteral nutrition

Fri Apr 01 00:00:00 EST 2005

Effects of vasoactive intestinal peptide and galanin on survival of cultured porcine myenteric neurons.

Regulatory peptides

Arciszewski MB,Ekblad E

A-21271 was used in immunohistochemistry - frozen section to examine the roles of galanin and vasoactive intestinal peptide on small intestinal porcine myenteric neuron survival

Tue Feb 15 00:00:00 EST 2005

Neural crest migration methods in the chicken embryo.

Methods in molecular biology (Clifton, N.J.)

Elena de Bellard M,Bronner-Fraser M

A-21271 was used in immunohistochemistry to discuss methods to study neural cell migration

Thu Apr 21 00:00:00 EDT 2005

NG2-expressing cells in the subventricular zone are type C-like cells and contribute to interneuron generation in the postnatal hippocampus.

The Journal of cell biology

Aguirre AA,Chittajallu R,Belachew S,Gallo V

A-21271 was used in immunohistochemistry - frozen section to assess the contribution to interneuron generation in the postnatal hippocampus by NG2-expression cells in the subventricular zone that are type C-like cells

Mon May 24 00:00:00 EDT 2004

Asymmetric production of surface-dividing and non-surface-dividing cortical progenitor cells.

Development (Cambridge, England)

Miyata T,Kawaguchi A,Saito K,Kawano M,Muto T,Ogawa M

A-21271 was used in Immunohistochemistry to study the cytogenetic and histogenetic events that trigger the emergence of the cortical plate.

Thu Jul 01 00:00:00 EDT 2004

An element in the alpha1-tubulin promoter is necessary for retinal expression during optic nerve regeneration but not after eye injury in the adult zebrafish.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Senut MC,Gulati-Leekha A,Goldman D

A-21271 was used in immunohistochemistry - frozen section to study the requirement for retinal expression during optic nerve regeneration by an element in the alpha1-tubulin promoter and not after eye injury in the adult zebrafish

Wed Sep 01 00:00:00 EDT 2004

Differentiation of human embryonic stem cells to dopaminergic neurons in serum-free suspension culture.

Stem cells (Dayton, Ohio)

Schulz TC,Noggle SA,Palmarini GM,Weiler DA,Lyons IG,Pensa KA,Meedeniya AC,Davidson BP,Lambert NA,Condie BG

A-21271 was used in immunocytochemistry to assess the ability of human embryonic stem cells to differentiate into dopamine-producing neurons in a simple serum-free suspension culture system

Thu May 12 00:00:00 EDT 2005

Specification of the retinal fate of mouse embryonic stem cells by ectopic expression of Rx/rax, a homeobox gene.

Molecular and cellular biology

Tabata Y,Ouchi Y,Kamiya H,Manabe T,Arai K,Watanabe S

A-21271 was used in immunocytochemistry to analyze ectopic expression of Rx/rax, a homeobox gene, that specifies the retinal fate of mouse embryonic stem cells

Sat May 01 00:00:00 EDT 2004

Action of bradykinin in the submucosal plexus of guinea pig small intestine.

The Journal of pharmacology and experimental therapeutics

Hu HZ,Gao N,Liu S,Ren J,Wang X,Xia Y,Wood JD

A-21271 was used in immunohistochemistry to use microelectrodes to study actions of bradykinin on electrical behavior of morphologically identified neurons and determine the localization of BK receptors in the submucosal plexus of guinea pig small intestine.

Thu Apr 01 00:00:00 EST 2004

Characterisation of neurons expressing calbindin immunoreactivity in the ileum of the unweaned and mature sheep.

Cell and tissue research

Chiocchetti R,Grandis A,Bombardi C,Clavenzani P,Costerbosa GL,Lucchi ML,Furness JB

A-21271 was used in immunohistochemistry to test if CALB-IR expressed in sheep Dogiel type II cells

Mon Nov 01 00:00:00 EST 2004

Molecular and functional analysis of hyperpolarisation-activated nucleotide-gated (HCN) channels in the enteric nervous system.

Neuroscience

Xiao J,Nguyen TV,Ngui K,Strijbos PJ,Selmer IS,Neylon CB,Furness JB

A-21271 was used in immunohistochemistry to determine the expression and localization of hyperpolarisation-activated nucleotide-gated isoforms in the enteric nervous systems of mice, rats and guinea-pigs

Mon Mar 07 00:00:00 EST 2005

Quantification of neurons in the myenteric plexus: an evaluation of putative pan-neuronal markers.

Journal of neuroscience methods

Phillips RJ,Hargrave SL,Rhodes BS,Zopf DA,Powley TL

A-21271 was used in immunocytochemistry and immunohistochemistry to assess the efficacy of four putative pan-neuronal markers for the enteric nervous system

Sun Feb 15 00:00:00 EST 2004

Increased expression of nitric oxide synthase in cultured neurons from adult rat colonic submucous ganglia.

Autonomic neuroscience : basic & clinical

Lin Z,Sandgren K,Ekblad E

A-21271 was used in immunohistochemistry - paraffin section to determine the expression of VIP and NOS in cultured submucous neurons from adult rat large intestine

Fri Jul 30 00:00:00 EDT 2004

Actions of bradykinin on electrical and synaptic behavior of neurones in the myenteric plexus of guinea-pig small intestine.

British journal of pharmacology

Hu HZ,Liu S,Gao N,Xia Y,Mostafa R,Ren J,Zafirov DH,Wood JD

A-21271 was used in immunohistochemistry to investigate the actions of bradykinin in neurons of the myenteric plexus of guinea-pig small intestine in vitro.

Tue Apr 01 00:00:00 EST 2003

Knockdown of the survival motor neuron (Smn) protein in zebrafish causes defects in motor axon outgrowth and pathfinding.

The Journal of cell biology

McWhorter ML,Monani UR,Burghes AH,Beattie CE

A-21271 was used in western blot to demonstrate that Smn contributes to motor axon development.

Mon Sep 01 00:00:00 EDT 2003

Noradrenergic neurons in the zebrafish hindbrain are induced by retinoic acid and require tfap2a for expression of the neurotransmitter phenotype.

Development (Cambridge, England)

Holzschuh J,Barrallo-Gimeno A,Ettl AK,Durr K,Knapik EW,Driever W

A-21271 was used in immunohistochemistry to characterize tfap2a mutant zebrafish

Mon Dec 01 00:00:00 EST 2003

Vasoactive intestinal peptide and nitric oxide promote survival of adult rat myenteric neurons in culture.

Journal of neuroscience research

Sandgren K,Lin Z,Fex Svenningsen A,Ekblad E

A-21271 was used in immunocytochemistry to test if vasoactive intestinal peptide and nitric oxide affect the survival of cultured, dissociated myenteric neurons

Sun Jun 01 00:00:00 EDT 2003

Evidence that two forms of choline acetyltransferase are differentially expressed in subclasses of enteric neurons.

Cell and tissue research

Chiocchetti R,Poole DP,Kimura H,Aimi Y,Robbins HL,Castelucci P,Furness JB

A-21271 was used in immunohistochemistry to compare peripheral ChAT distribution with that of the common form of ChAT

Wed Jan 01 00:00:00 EST 2003

HuC/D confocal imaging points to olfactory migratory cells as the first cell population that expresses a post-mitotic neuronal phenotype in the chick embryo.

Neuroscience

Fornaro M,Geuna S,Fasolo A,Giacobini-Robecchi MG

A-21271 was used in immunohistochemistry - paraffin section to identify the first population of post-mitotic neurons in the developing nervous system of the chick embryo

Fri Mar 19 00:00:00 EST 2004

Increased expression of vasoactive intestinal polypeptide in cultured myenteric neurons from adult rat small intestine.

Autonomic neuroscience : basic & clinical

Lin Z,Sandgren K,Ekblad E

A-21271 was used in immunocytochemistry to investigate vasoactive intestinal polypeptide and nitric oxide synthase in cultured myenteric ganglia and dissociated neurons.

Fri Aug 29 00:00:00 EDT 2003

Immunocytochemistry as a tool for zebrafish developmental neurobiology.

Methods in cell science : an official journal of the Society for In Vitro Biology

Novak AE,Ribera AB

A-21271 was used in immunohistochemistry to describe methods to observe antibody localization in zebrafish whole mount preparations

Tue Sep 21 00:00:00 EDT 2004

The ghrelin cell: a novel developmentally regulated islet cell in the human pancreas.

Regulatory peptides

Wierup N,Svensson H,Mulder H,Sundler F

A-21271 was used in immunohistochemistry to determine if ghrelin is expressed in human pancreas.

Mon Jul 15 00:00:00 EDT 2002

Müller glia are a potential source of neural regeneration in the postnatal chicken retina.

Nature neuroscience

Fischer AJ,Reh TA

A-21271 was used in immunohistochemistry to show that the retina of postnatal chickens can generate new neurons

Thu Mar 01 00:00:00 EST 2001

Retinal ganglion cell genesis requires lakritz, a Zebrafish atonal Homolog.

Neuron

Kay JN,Finger-Baier KC,Roeser T,Staub W,Baier H

A-21271 was used in immunohistochemistry to investigate the role of zebrafish lakritz (lak) locus in the developing retina.

Fri Jun 01 00:00:00 EDT 2001

Asymmetric inheritance of radial glial fibers by cortical neurons.

Neuron

Miyata T,Kawaguchi A,Okano H,Ogawa M

A-21271 was used in immunohistochemistry - frozen section to analyze the inheritance pattern of asymmetry by radial glial fibers by cortical neurons

Thu Sep 13 00:00:00 EDT 2001

Evidence of very early neuronal migration from the olfactory placode of the chick embryo.

Neuroscience

Fornaro M,Geuna S,Fasolo A,Giacobini-Robecchi MG

A-21271 was used in immunohistochemistry - paraffin section to study migration of cells from the olfactory neuroepithelium in chickens

Mon Dec 17 00:00:00 EST 2001

P2X(7) receptors in the enteric nervous system of guinea-pig small intestine.

The Journal of comparative neurology

Hu HZ,Gao N,Lin Z,Gao C,Liu S,Ren J,Xia Y,Wood JD

A-21271 was used in immunohistochemistry to investigate the role of P2X(7) receptors in the enteric nervous system.

Mon Nov 19 00:00:00 EST 2001

Confocal imaging of HuC/D RNA-binding proteins in adult rat primary sensory neurons.

Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft

Fornaro M,Geuna S

A-21271 was used in immunohistochemistry - paraffin section to determine the cellular distribution of HuC/D RNA-binding proteins in adult rat primary sensory neurons

Sat Sep 01 00:00:00 EDT 2001

Hu antigen specificities of ANNA-I autoantibodies in paraneoplastic neurological disease.

Journal of autoimmunity

King PH,Redden D,Palmgren JS,Nabors LB,Lennon VA

A-21271 was used in ELISA and western blot to correlate the immunoreactivity of all four Hu antigens in sera from 75 patients with ANNA-1 autoantibodies with clinical parameters

Wed Dec 01 00:00:00 EST 1999

Hu protein as an early marker of neuronal phenotypic differentiation by subependymal zone cells of the adult songbird forebrain.

Journal of neurobiology

Barami K,Iversen K,Furneaux H,Goldman SA

A-21271 was used in immunohistochemistry and western blot to follow the commitment of newborn cells to neuronal lineage in the avian forebrain

Fri Sep 01 00:00:00 EDT 1995

HuD, a paraneoplastic encephalomyelitis antigen, contains RNA-binding domains and is homologous to Elav and Sex-lethal.

Cell

Szabo A,Dalmau J,Manley G,Rosenfeld M,Wong E,Henson J,Posner JB,Furneaux HM

A-21271 was used in western blot to use antibody-associated paraneoplastic encephalomyelitis patient sera to identify a neuronal antigen HuD

Fri Oct 18 00:00:00 EDT 1991

Bioinformatics

Protein Aliases:

ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C); ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D); ELAV-like protein 3; ELAV-like protein 4; elav-related C; elav-related D; elavC; embryonic lethal, abnormal vision-related C; embryonic lethal, abnormal vision-related D; etID309927.3; Hu antigen C; Hu antigen D; Hu-antigen C; Hu-antigen D; HuC; HuD; Paraneoplastic cerebellar degeneration-associated antigen; Paraneoplastic encephalomyelitis antigen HuD; Paraneoplastic limbic encephalitis antigen 21; Protein elrD; RNA-binding protein HuD

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Gene Aliases:

ELAVL3; ELAVL4; elrc; elrd; HUC; HUCL; HUD; id:ibd1248; PLE21; PNEM; wu:fb77b03; wu:fc24h01; zHuC

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UniProt ID:

(Human) Q14576, (Human) P26378, (Zebrafish) A0A0R4IEW8

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Entrez Gene ID:

(Human) 1995, (Chicken) 395634, (Human) 1996, (Zebrafish) 30732, (Zebrafish) 30737

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Molecular Function:

translation initiation factor

Function(s)

nervous system development

cell differentiation

RNA processing

mRNA processing

regulation of neurogenesis

RNA splicing

Process(es)

nucleotide binding

AU-rich element binding

RNA binding

mRNA 3'-UTR binding

nucleic acid binding

It has to be done as per old AB suggested Products section.

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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HuC/HuD Monoclonal Antibody (16A11) (A-21271)

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